Delighted to be part of the CF Lung Health Network Innovation Hubs via @pulse-cf.bsky.social. Privilege to work alongside so many talented students, researchers, clinicians and pwCF, all striving towards the same goal! Looking forward to see what we can achieve together over the coming years. 🧬🫁

Cystic Fibrosis Trust@cysticfibrosis.org.uk · 4w ago

Last week concluded the last of our recent visits to the four Innovation Hubs that make up our CF Lung Health Network, co-funded by the Trust and LifeArc. Swipe for a recap of the four programmes and click the link to find out more. https://ow.ly/qPMi50Zl7B4 #cysticfibrosis

These findings help explain the neutral clinical outcomes observed in the parent trial and suggest that adding further antibiotics based on sputum microbiome profiling is unlikely to improve treatment response. Thanks to all patients and the CFMATTERS consortium! #CF #Microbiome #AJRCCM #ERJ

Using 16S rRNA sequencing, qPCR and neutrophil elastase measurements, we found that standard IV antibiotics produced transient reductions in bacterial burden and airway inflammation. Adding a microbiome-directed third antibiotic provided no additional microbiological or inflammatory benefit.

Delighted to share our latest Research Letter in AJRCCM! This microbiome sub-analysis of the CFMATTERS trial follows our recent ERJ publication evaluating microbiome-directed antibiotic therapy during CF pulmonary exacerbations. academic.oup.com/ajrccm/artic...

Does media matter? RNAseq of S. aureus growing in LB broth vs. synthetic wound fluid shows differential expression of genes involved in efflux, virulence & ion transport. Work led by @tosinorababa.bsky.social: his first manuscript from independent funding! #MicroSky www.biorxiv.org/content/10.6...

Does media matter? Growth environment influence antimicrobial tolerance and expression of virulence and transmembrane ion transport-associated genes in MRSA

Clinically relevant pathogens are often tested for antimicrobial susceptibility using standard laboratory media that poorly reflect the in vivo environments in which they cause infections, leading to ...

biorxiv.org

Very interesting paper from @timskvortsov.bsky.social group at @qubelfastofficial.bsky.social

Timofey Skvortsov@timskvortsov.bsky.social · 2mo ago

Happy to announce that the second paper from the doctoral work of Akash Shambharkar describing two Proteus phage endolysins, is now available on the website of the journal Applied Microbiology and Biotechnology doi.org/10.1007/s002... #phage #endolysin #lysin

Delighted to see my friend Aram Kadoom win the Best Poster Award #ECFS2026 for his work on rapid saliva-based detection of P. aeruginosa using LAMP. A promising step towards faster, less invasive infection monitoring in CF. Congratulations to Aram and the team! #QUB #PULSE-CF #CFTrust #LifeArc

Our new paper published online early in Microbiome On long-term impact of #CFTRmodulators on the lung #microbiome across adults living with #cysticfibrosis from centres in UK, USA, and Canada @hgavillet.bsky.social link.springer.com/article/10.1...

Remodelling of cystic fibrosis respiratory microbiota in response to extended elexacaftor–tezacaftor–ivacaftor therapy - Microbiome

Background Cystic fibrosis (CF) has profoundly changed since the introduction of CF Transmembrane Conductance Regulator modulator therapies (CFTRmt), a class of medications that improve function of th...

link.springer.com

Another new paper. This time a mini review on the gut-lung axis in #CF just published in the Journal of #CysticFibrosis www.sciencedirect.com/science/arti...

Towards a gut-lung axis role in pwCF on CFTR modulators: rationale, clinical evidence and perspectives

Recent data support the existence of a “gut-lung axis” (GLA), yet it’s role in chronic respiratory diseases, like cystic fibrosis (CF), is under inves…

sciencedirect.com

📣 Whelan lab is hiring 📣 We are looking for an entry level technician to help us with our culturing and DNA sequencing prep of cystic fibrosis lung microbiome samples. Applications close 20 May 2026. www.jobs.manchester.ac.uk/Job/JobDetai...

Research Technician in Microbiology and Molecular Biology:Oxford Road

jobs.manchester.ac.uk

Delighted to be part of this study led by Dr Michael McKelvey & Prof Cliff Taggart at @QUBelfast exploring the effects of hypertonic saline and/or carbocisteine on sputum rheology in bronchiectasis (CLEAR-EME). 🔗 publications.ersnet.org/index.php/co... #Bronchiectasis #Microbiome #Rheology

Delighted to share the final version of our Short Communication in @JournalCF. We show that upper airway samples do not reliably reflect lower airway microbiota in awCF- highlighting key challenges for microbial surveillance in the modulator era. Link: tinyurl.com/y7cr34c9

Assessing the reliability of upper airway sampling for microbiological surveillance in cystic fibrosis

Sputum analysis is the standard method for microbiological surveillance in cystic fibrosis (CF). However, CFTR modulator therapy has markedly reduced …

tinyurl.com

This week we’re highlighting how people with CF and their loved ones are shaping the direction of the CF Lung Health Network, co-funded by #CFTrust and LifeArc. ➡️ https://ow.ly/NqBi50YseGq

This week we’ve been visiting researchers within our Translational Innovation Hub Network for CF Lung Health and Infection funded by the Trust and LifeArc. Find out more about our Trailfinder-CF and Pulse-CF Innovation hubs on our website. ➡️ https://ow.ly/iERe50Yp1g7 #cysticfibrosis #cftrust

Looking for a PhD? The following posts are now available at the University of Liverpool.

PhD studentship @manmetuni.bsky.social applications now open! Interested in the mechanisms of microbial invasion in respiratory disease? This @cysticfibrosis.org.uk match funded PhD might be for you! www.findaphd.com/phds/project...

Interrogating microbiomes and metabolomes during P. aeruginosa infiltration and colonisation in CF respiratory tract infection at Manchester Metropolitan University on FindAPhD.com

PhD Project - Interrogating microbiomes and metabolomes during P. aeruginosa infiltration and colonisation in CF respiratory tract infection at Manchester Metropolitan University, listed on FindAPhD.c...

findaphd.com

Delighted to share our new research (In Print) "Biofilm communities above and below the cuff of endotracheal tubes are spatially homogenous" led by Dr Laura Sherrard (QUB; tinyurl.com/ys9pttmw) and funded by NICHS (@nichstweet) now out in @RespiratoryBMC. #ICUresearch #Microbiome #OA rdcu.be/e0hga

🧬 PhD Opportunity in #CF with our Group at QUB in Belfast and www.pulse-cf.com 🫁 to study pulmonary exacerbations using cutting-edge multi-omics approaches. 🔬 Lung–gut axis 🎓 Fully funded (UK and ROI) LINK: tinyurl.com/56np78r2 #Microbiome #MultiOmics #Bioinformatics

Great to see the final version of our paper "Molecular endotyping in people with bronchiectasis based on response to antibiotic treatment: iBEST study" doi.org/10.1183/2312... now out in ERJ Open Research @ERSpublications #Bronchiectasis #Microbiome

Delighted to share our Short Communication in @JournalCF (Articles in Press), led by Dr Rob Lord in Manchester: "Assessing the reliability of upper airway sampling for microbiological surveillance in cystic fibrosis - Journal of Cystic Fibrosis www.cysticfibrosisjournal.com/article/S156...

Assessing the reliability of upper airway sampling for microbiological surveillance in cystic fibrosis

The airway microbiota plays a crucial role in CF pathophysiology, with altered microbial composition associated with lung disease severity and progression [1–3]. Traditionally, sputum analysis has bee...

cysticfibrosisjournal.com

@profjdchalmers.bsky.social @dbogaert.bsky.social @edinburgh-uni.bsky.social @eswinfluenza.bsky.social @lungfoundation.bsky.social @meretelong.bsky.social @balrcommunity.bsky.social @arns-uk.bsky.social @uofglasgow.bsky.social

Delighted to share our new collaborative study led by Anne Mette Madsen (nfa.dk) on microbial & dust exposures in waste-recycling workers and links to inflammation. sciencedirect.com/science/articl… #EXIMIOUS (eximious-h2020.eu)

Delighted to be able to share (Early View) our new paper “Molecular endotyping in people with bronchiectasis based on response to antibiotic treatment: iBEST study” in ERJ Open Research publications.ersnet.org/content/erjor/… #Bronchiectasis #qPCR #Microbiome #endotype

Delighted to be a part of this and being able to share the Early View of our multi-centre CFMATTERS study in ERJ (@ERSpublications)! Can microbiome-guided antibiotics improve PEx treatment in pwCF? 🔗 doi.org/10.1183/139930… �� cfmatters.s.eu #CF #Microbiome #Antibiotics #CFMATTERS

Fantastic to see the CF-Tracker study taking off!

PULSE-CF Research Innovation Hub@pulse-cf.bsky.social · last yr.

Our first CF-Tracker study participant started the study today! First of many for this exciting @cftrustuk.bsky.social @lifearc.bsky.social funded Research Innovation Hub. Huge thanks to the team and to @nihr.bsky.social Manchester CRF!

Three fully funded PhD’s available! Looking for talented applicants with microbiology experience to study the role of microbes in cystic fibrosis exacerbations as part of the PULSE-CF Innovation Hub www.pulse-cf.com Find out more and apply at: go.qub.ac.uk/CFPhDs

tunney PhD Projects, Programmes & Scholarships

FindAPhD. Search Funded PhD Projects, Programmes & Scholarships in tunney. Search for PhD funding, scholarships & studentships in the UK, Europe and around the world.

go.qub.ac.uk

Gutting the CDC right as we’re on the cusp of major outbreaks of transmissible diseases is a very bad idea.

Delighted to be presenting our poster on “Beyond the cuff - characterising biofilm-forming microorganisms on endotracheal tubes in critically ill patients” at the #RTI2025 in Glasgow a project funded by Northern Ireland Chest Heart and Stroke @nichstweets

Great PhD opportunity as part of a large and exciting new research hub in cystic fibrosis! More info below or www.pulse-cf.com

Fiona J Whelan@whelanfj.bsky.social · 2y ago

🚨 PhD opportunity 🚨 The Whelan lab & @brockhurstlab.bsky.social are seeking a PhD student interested in investigating the ecol & evol of pathogens in cystic fibrosis exacerbations. This PhD is funded as part of @pulse-cf.bsky.social w @alexhorsley.bsky.social et al. More info & link to apply below.

Our second presentation within the Infection and Antimicrobial Resistance theme is by Thomas Thompson on 'Harnessing Cold Plasma to Combat Biofilm-Associated Infections'