So excited to see this published! This method was a long time in the making and is now being widely used to balance scale with depth, especially for participants where unbiased sequencing approaches are so much more useful than arrays

Broad Institute@broadinstitute.org · 4w ago

Broad scientists developed the Blended Genome Exome (BGE) sequencing method, which delivers high-quality, unbiased data at a lower cost than existing gold-standard methods and makes large-scale genetic studies more feasible. @genetisaur.bsky.social

NIH All of Us has just released a massive multi-omics dataset, including: • 535K WGS (120K+ added; now larger than UKB) • ~10K proteomics + RNAseq + long-read • ML-curated clinical notes • 68K with Fitbit data Kudos to this great initiative and to the participants for advancing science

Population geneticists! Come work at 23andMe! New role just posted. 23andme.wd5.myworkdayjobs.com/23/job/Palo-...

📣 𝐖𝐞’𝐫𝐞 𝐡𝐢𝐫𝐢𝐧𝐠 𝐚 𝐩𝐨𝐬𝐭𝐝𝐨𝐜 𝐢𝐧 𝐩𝐨𝐩𝐮𝐥𝐚𝐭𝐢𝐨𝐧 & 𝐬𝐭𝐚𝐭𝐢𝐬𝐭𝐢𝐜𝐚𝐥 𝐠𝐞𝐧𝐞𝐭𝐢𝐜𝐬! 🌍📈🧬 If you’re finishing a PhD (or know someone who is) and want to work on complex trait biology + 𝑟𝑒𝑎𝑙-𝑤𝑜𝑟𝑙𝑑 𝑖𝑚𝑝𝑎𝑐𝑡, read on 👇

🎉New preprint: Phenome-derived polygenic scores and social determinants jointly shape context-dependent disease risk. We evaluate disease risk along 2 complementary axes: • how genetic liability is represented • the social context in which it is expressed

medRxivpreprint@medrxivpreprint.bsky.social · 4mo ago

Phenome-derived polygenic scores and social determinants jointly shape context-dependent disease risk https://www.medrxiv.org/content/10.64898/2026.04.16.26351039v1

Family quarantine complete! 3 yo had flu A and was confined to room with dad caretaking while I took care of 2 month old. Combo tests in the house meant we diagnosed right away, despite weird stomach flu-like symptoms. Tamiflu is a wonder drug if in time! Treated and prophylaxis: no one else sick

Interested in pleiotropy dissection but not sure where to start, which methods are useful, which studies offer illustrative examples, or how to robustly validate your results? Look no further 👀 rdcu.be/eSfAZ

Dissecting pleiotropy to gain mechanistic insights into human disease

Nature Reviews Genetics - Genome-wide association studies of increasing scale have revealed the prevalence of pleiotropic genetic variants that affect multiple traits. In this Review, the authors...

rdcu.be

A project many years in the process, we’re pleased to present our work on multi-ancestry meta-analysis across a boatload of traits in the UK Biobank: www.nature.com/articles/s41...

Pan-UK Biobank genome-wide association analyses enhance discovery and resolution of ancestry-enriched effects - Nature Genetics

Genome-wide analyses for 7,266 traits leveraging data from several genetic ancestry groups in UK Biobank identify new associations and enhance resources for interpreting risk variants across diverse p...

nature.com

Kristin Tsuo, @genetisaur.bsky.social, & Mark Daly just wrote the best proteomics paper I've read. They convincingly show how smoking and alcohol (aka, the environment) dramatically influences proteomics data. Some 🤯 results 1) proteomics predicts frequency (5a) & quanity (5b) of alcohol consumed

On the new acting CDC director. www.theguardian.com/us-news/2025...

The Govt. Accountability Office issued a report today finding that the Trump admin has violated a law blocking presidents from withholding funding Congress has approved @mmolteni.bsky.social & I break it down: www.statnews.com/2025/08/05/g...

Trump administration violated impoundment law by canceling NIH grants, slowing new awards, GAO finds

The Government Accountability Office found that the Trump administration, by abruptly canceling NIH grants, had violated a 1974 federal law

statnews.com

Every reputable expert I know considers mRNA vaccine technology to be one of the most revolutionary advances in medicine in our lifetimes. Its inventors won the Nobel Prize in 2023. Shutting it down now is pointless self-harm to humanity.

Eric Michael Garcia@ericmgarcia.bsky.social · last yr.

Release from HHS: HHS will wind down its development of the mRNA vaccine development activities under the Biomedical Advanced Research and Development Authority (BARDA).

Let’s not pretend this ends with Harvard. This will be every American university unless a resounding legal win establishes precedent

Dan Garisto@dangaristo.bsky.social · last yr.

For reference, the NSF letter for UCLA's suspensions is on the left, while the letter for Harvard's terminations is on the right.

Incredibly well reported deep dive on NIH and health disparities research in STAT. 🧵 www.statnews.com/2025/08/01/n... 1/31

Jay Bhattacharya once studied health disparities. As NIH director, he’s allowed such research to wither

Jay Bhattacharya’s tenure as NIH director has seen health disparities research swept up in the Trump administration’s attack on DEI

statnews.com

The NIH can’t award ANY grants to outside researchers under new WH restriction, reports @wsj.com. The pause came in the form of a footnote from OMB Director Vought, in a document that doles out federal funds to the NIH. Prelude to rescissions, especially after his comments over the weekend?

Trump Administration Puts New Chokehold on Billions in Health-Research Funding

The National Institutes of Health can’t award grants to outside researchers under a new White House restriction.

wsj.com

Wonderful tribute to a dear colleague- well worth the read www.ucsf.edu/news/2025/06...

UCSF Bioinformatics Pioneer Atul Butte Dies at 55

Atul Butte, who championed the use of big data in science and health care and inspired a generation of trainees at UC San Francisco and beyond to pursue the fields he pioneered — translational and cli...

ucsf.edu

📢 Just posted: Our preprint introducing SPC — Spectral Components — is now live on medRxiv! Led by Dr. Ruhollah Shemirani and years in the making, this method offers a robust, scalable way to adjust for recent population structure in genomic analyses. 🔗 www.medrxiv.org/content/10.1... 1/9

SPC: a SPectral Component approach to address recent population structure in genomic analysis

Population structure is a well-known confounder in statistical genetics, particularly in genome-wide association studies (GWAS), where it can lead to inflated test statistics and spurious associations...

medrxiv.org

🚨 BREAKING: Nearly 4 months the NIH cut its first grants, a judge has ruled that the directives and process that led to cuts are arbitrary and capricious. "The explanations are bereft of reasoning — virtually in their entirety... unsupported by [facts]." Each of them are VOID and ILLEGAL, he says.

"We are speaking on behalf of hundreds of NIH staff who are standing up together to say: WE DISSENT. I am so scared about doing this but I am trying to be brave for my kids because it's only gonna get harder to speak up." Thank you to Dr. Jenna Norton and NIH scientists for your courage!

"Our calculations suggest that the proposed budgetary cuts to the NIH will create a social cost that is 16 times greater than the savings that the administration is attempting to achieve." jamanetwork.com/journals/jam...

Cutting the NIH—The $8 Trillion Health Care Catastrophe

This JAMA Forum discusses the recent budget cuts to National Institutes of Health (NIH), the effects of these cuts on scientific research and health of individuals in the US, and the prospects for cha...

jamanetwork.com

Now published! Congrats Yon Ho on this huge lift conducting dozens of GWAS in Korea and performing meta-analyses with other Asian biobanks reaching a sample size comparable to UK Biobank. The fine-mapping, novel loci, and ancestry-enriched discoveries are very cool. www.nature.com/articles/s41...

Genome-wide association studies in a large Korean cohort identify quantitative trait loci for 36 traits and illuminate their genetic architectures - Nature Communications

Here the authors identify hundreds of genetic loci linked to 36 traits in East Asians, revealing population-specific associations and emphasizing the importance of diverse ancestry groups in genome-wi...

nature.com

Statement from the American College of Obstetricians and Gynecologists

ACOG@acog.org · last yr.

ACOG is deeply disappointed by HHS’s move to drop COVID-19 vaccine recommendations in pregnancy. The science is clear: COVID-19 remains dangerous in pregnancy and vaccination protects both patients and newborns. The vaccine is safe and protects families. Read our full statement: buff.ly/OGue7sO

America cannot long remain free, nor first among nations, if it becomes the kind of place where universities are dismantled because they don't align politically with the current head of the government.

🚨This is a HUGE escalation and a deliberate effort to use the government against Trump's enemies. Weaponizing the Student and Exchange Visitor Program certification against Harvard to punish them for pushing back is a new low — and needlessly punishes thousands of innocent students.

Alejandra Caraballo@esqueer.net · last yr.

Trump just revoked the ability for foreign students to enroll at Harvard. Every foreign student, which is in the thousands, enrolled for next year at Harvard will not be able to continue studying if this isn't challenged in court. www.nytimes.com/2025/05/22/u...

The 80-year recipe stoking America’s Prosperity: 1) Free-market capital investments in brilliant ideas… 2) enabled by Engineering Innovations… 3) based on Science Research in Universities… 4) funded by Grants from the US Government. It’s time more people understood this.

She’s out!! They have released Ozturk from ICE custody!

And just today the EIC of Nature Neuroscience told me in public that they are a for-profit company and if they had to pay reviewers they would "need" to raise prices.

hakwan lau@hakwan.bsky.social · last yr.

who says that science doesn't generate profit?

Breast cancer diagnoses rose by over 300% between 1973 and 1992. Was there a breast cancer epidemic?! NO. Mammograms were implemented for screening in 1976. PREVALENCE is a function of being able to correctly diagnose something. This is also about autism.

I've received additional confirmation, as well as an email I can share publicly. See the directive NIH grants management staff received from Michelle Bulls, director of extramural policy at NIH:

🚨 PGC Africa Monthly Meeting Alert! We are delighted to have Dr Lerato Majara from the Martin Lab @genetisaur.bsky.social, @broadinstitute.org join our 3rd virtual meeting of 2025 📆 24th April 2025 ⏲️ 2PM GMT | 2PM WAT | 3PM CAT | 4PM EAT 📢 More details on the flyer below #Psychosis #Africa #GWAS