2 days until @FASEB Phospholipids! Can't wait to see everyone and nerd out for a week of lipid and membrane biology 🙌

Excited that the dual PI3K/mTOR inhibitor gedatolisib was approved in breast cancer. Always nice to see positive clinical results for molecules my lab has studied. It is interesting as it causes large scale conformational changes in PI3K elifesciences.org/articles/64691, www.rcsb.org/structure/7JWE

Disease-related mutations in PI3Kγ disrupt regulatory C-terminal dynamics and reveal a path to selective inhibitors

The c-terminus of PI3K plays a key role in regulating kinase activity, with c-terminal disease-linked mutations leading to either activation or inhibition, which reveal a path to specific inhibitors.

elifesciences.org

Spot the dimer - GUESS the dimer?

The unparalleled productivity boost of the dual monitor set up!

There’s still time to register for the FASEB Phospholipids in Aging and Disease conference! The scientific program will be posted next week, and registration is open until July 19. We’d love to see you in Scottsdale! #lipidtime #FASEB

Don't forget - last chance for early registration this weekend! #FASEB #Lipidtime

Gerry Hammond@gerryhammond.bsky.social · 2mo ago

Last few slots are available for the FASEB phospholipids meeting in Arizona this July. Sign up today! events.faseb.org/event/Phosph...

Last few slots are available for the FASEB phospholipids meeting in Arizona this July. Sign up today! events.faseb.org/event/Phosph...

It won’t take you years to publish your work in JCS: most articles go from submission to acceptance in under 5 months. We also show a strong commitment at first decision, with over 95% of revisions being accepted. Find out more: journals.biologists.com/jcs/pages/re... #forscientistsbyscientists

Don't forget - last couple of days to sign up!!! Hope to see you all in AZ 😀 events.faseb.org/event/Phosph...

Gerry Hammond@gerryhammond.bsky.social · 2mo ago

Last week to sign up for this summer's #FASEB phospholipids meeting! We have lots of slots for selected speakers - put your abstract in today and tell us your awesome lipid story in Arizona. Registration closes May 31. See you there! #lipidtime events.faseb.org/event/Phosph...

Last week to sign up for this summer's #FASEB phospholipids meeting! We have lots of slots for selected speakers - put your abstract in today and tell us your awesome lipid story in Arizona. Registration closes May 31. See you there! #lipidtime events.faseb.org/event/Phosph...

Ready to give my talk at @biologists.bsky.social “imaging cell dynamics… over!

Visit our fully accessible journal archive, providing perpetual access to 34k articles from over a century of pioneering research in developmental biology, cell biology, comparative physiology and biomechanics, including work from 60+ Nobel Prize-winners bit.ly/3PfIjib

Exciting new work on inter-organelle lipid transfer, from our always-friends and sometimes-collaborators in the Conibear lab at UBC:

Journal of Cell Biology@jcb.org · 5mo ago

Hoi1 targets BLTP2 to ER–PM contact sites to regulate #lipid homeostasis. New study from Samantha K. Dziurdzik, Vaishnavi Sridhar, Elizabeth Conibear @lizconibear.bsky.social and colleagues (University of British Columbia): rupress.org/jcb/article/... #Genetics #MembraneContactSites #ER_literature

Beautiful desert views. Beautiful membrane biology. Join us for the #FASEB Phospholipids in Aging and Disease SRC in Arizona, July 26–30 2026. Registration is now open! So much better than a Lipid Droplets conference. Also, we're co-located with FASEB Lipid Droplets 😜

Congratulations to Jesus Calixto on passing his comprehensive exam - loved this power move showcasing the towering knowledge of MARCKS proteins he's accrued in two years!

A fascinating look at the frankly bonkers, still-mysterious relationship between master membrane regulator PIP2 and its precursor. Another classic from Min Wu's lab!

Distinct impact of PI(4)P flux on PI(4,5)P2 steady states and oscillations | PNAS

Plasma membrane (PM) phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2] regulates indispensable processes such as exocytosis, endocytosis, and actin...

pnas.org

Lipids are kind of the ignored middle children of origins of life research. It's time they got a bit of attention, too! This week's post is a Q&A with geoscientist-turned-??? (interdisciplinary folks know the struggle) @jamessaenz.bsky.social about why there's no cutting the fat from origins. 🧪

The origin of life wasn't fat-free

James Sáenz studies how fatty molecules might have helped life get started

reviewertoo.com

Thrilled to share our latest study, led by @reikatei.bsky.social, in @natchembio.nature.com! We began by asking a simple question—how do cells know if they have too much of a lipid in a particular membrane, and how do they respond to rectify this imbalance? www.nature.com/articles/s41... More info 👇

Membrane editing with proximity labeling reveals regulators of lipid homeostasis - Nature Chemical Biology

Coupling an optogenetic lipid-modifying enzyme with proximity labeling reveals protein networks and mechanisms regulating lipid homeostasis in the membranes of target organelles.

nature.com

Congratulations @cwecks.bsky.social on a first class thesis defense! It’s been a privilege to work with you for the last 6 years. And touche casting shade on my britishisms!

Cool new paper (www.jbc.org/article/S002... from my lab spearheaded by graduate students Sushant @sushantsuresh.bsky.social and Alex @alexlouiseshaw.bsky.social . This was a very cool collaboration with the Scott Hansen, Jennifer Cobb, Tamas Balla labs

Channeling my Robert Millikan!

Levental Lab@leventallab.bsky.social · 10mo ago

Gerry Hammond @gerryhammond.bsky.social rocking #BiomembraneDays25 with an awesome story on how PIP lipids are regulated!

So much looking forward to get going!

Dimova Lab@dimovalab.bsky.social · 10mo ago

🎉 Finally: tomorrow Sept 29 we open BIOMEMBRANE DAYS 2025 in Berlin: 3 days packed with exciting science on membranes! Looking forward to an amazing program of invited & contributed talks, posters & lively discussions. 📍 events.mpikg.mpg.de/event/15/ @ewerslab.bsky.social @mpici.bsky.social

I am super excited to announce that we have a tenure-track faculty position in biophysics open in the Department of Physics at Carnegie Mellon! 🧪 Interfolio link: apply.interfolio.com/174360 PLEASE, share widely across the blue skies! Let me briefly explain what we're looking for: 1/10

Josh Morgan discusses how progress in cell biology is hindered by significance testing and the need for a shift to effect size estimation. rupress.org/jcb/article/... 📕 In #Reproducibility and Best Practices in Cell Biology: rupress.org/jcb/collecti...

Always good to read JB and his lab's insights into one of the most important cancer targets, especially with their incredibly clear illustrations. So simple a basic cell biologist can follow it!

John Burke@jburkevic.bsky.social · 11mo ago

New review out from my lab on class I PI3Ks www.sciencedirect.com/science/arti..., was fun to write where we are and where we are going in PI3K research Great work from Isobel and Alex in my lab @alexlouiseshaw.bsky.social

Announcing our new PA biosensor, PILS-Nir1 – seen here in HeLa cells during PLC activation #lipidtime #phospholipids Read the OA paper in JCB

Rockefeller University Press@rupress.org · 11mo ago

In @jcb.org, @cwecks.bsky.social, Rahn, @gerryhammond.bsky.social et al. report a novel biosensor, PILS-Nir1, that detects phosphatidic acid in live cells, revealing the lipid’s dynamics with improved sensitivity and selectivity over existing probes. rupress.org/jcb/article/... #phospholipids

How do swelling lysosomes not burst? Because they literally suck more lipids into their membranes from the ER via this protein straw. Amazing piece of this particular molecular puzzle from my colleague jay tab!

Cell Biology J-Club@cellclub.bsky.social · 12mo ago

LYVAC/PDZD8 is a lysosomal vacuolator | Science www.science.org/doi/10.1126/...

This is such a beautiful mechanism for #phosphoinositide mediated regulation of integral membrane protein. Highly recommended #lipidtime read!!

Nature Structural & Molecular Biology@natsmb.nature.com · last yr.

ICYMI: New online: Structural basis of ClC-3 transporter inhibition by TMEM9 and PtdIns(3,5)P2

This is the author of an eye-opening paper - tracking back through evolution to figure out the still very enigmatic function of a lipid kinase. It’s changed my view on these enzymes, and leaves me with many questions. That's what all the best papers do!

Journal of Cell Science@jcellsci.bsky.social · last yr.

Read more about this research in our ‘First person’ interview with Harini Krishnan: journals.biologists.com/jcs/article/...

Whoa! Your weekend #lipidtime read: Our best view yet of lipids flowing along a bridge. Stunning work! If only we could see the “one-way” sign… www.nature.com/articles/s41...

Structural basis of lipid transfer by a bridge-like lipid-transfer protein - Nature

The LPD-3 complex structure reveals protein–lipid interactions that suggest a model for how the native LPD-3 complex mediates bulk lipid transport and provides a foundation for mechanistic studies of ...

nature.com