Gregor Hagelueken
@gha14.bsky.social
Structural Biologist. Likes Proteins - most of the time.
Hurray! ImmunoSensation will go on! 🥳 The @dfg.de just announced that ImmunoSensation3, focussing on Immune Diversity will be funded! Let us #celebrate 7 more years of #immunology in #Bonn 🎉 www.immunosensation.de/news/immunos...
Excellence Strategy Funds Bonn Cluster for Immune Research
The Bonn Cluster of Excellence ImmunoSensation will be funded for a further seven years as part of the Excellence Strategy of the German federal and state…
immunosensation.de
A landmark success! The University of Bonn secured funding for all six existing Clusters of Excellence and both new initiatives – more than any other German university. More: www.uni-bonn.de/en/news/095-... © G. Hübl, V. Lannert, M. Thürbach/ECONtribute, J. F. Saba/UKB, S. Wegener/ML4Q; N. Wietrich
Happy to share our first foray into the world of AI-based #ProteinDesign. www.biorxiv.org/content/10.1...
Development of AI-designed protein binders for detection and targeting of cancer cell surface proteins
Artificial intelligence (AI)-based protein design opens new avenues for the rapid generation of new research tools and therapeutics, but experimental validation lags behind the computational design th...
biorxiv.org
Can AI-designed binders degrade, aggregate, stain and enrich endogenous proteins in human cells? Check out our new preprint! www.biorxiv.org/content/10.1...
Transposon-Display of AI-designed binders enables manipulation of the proteome in human cells
Transposon-Display is a highly scalable screening method that links proteins to their encoding DNA during expression in E. coli via a mutant transposase. Leveraging this system, we identified AI-desig...
biorxiv.org
Please also check out another exciting work on AI-based protein design, which was a fantastic team effort with Michael Hölzel, @gha14.bsky.social, Tobias Bald and many colleagues at @unibonn.bsky.social www.biorxiv.org/content/10.1...
Development of AI-designed protein binders for detection and targeting of cancer cell surface proteins
Artificial intelligence (AI)-based protein design opens new avenues for the rapid generation of new research tools and therapeutics, but experimental validation lags behind the computational design th...
biorxiv.org
Out today @ Science: TIR signaling activates caspase-like immunity in bacteria We report a new immune signaling molecule: N7-cADPR. Produced by phage-induced TIRs and activates a defensive bacterial caspase Congrats Francois Rousset, Ilya Osterman and coauthors! www.science.org/doi/10.1126/...
www.nature.com/articles/s41...
A blueprint for broadly effective bacteriophage-antibiotic cocktails against bacterial infections - Nature Communications
The application of phage therapy for multidrug-resistant infections is mainly limited to personalized therapy due to the narrow host range of individual phages. Here, Kim et al. identify groups of pha...
nature.com
Congratulations to @philipphendricks.bsky.social for winning the #PosterPrize at this year's #ClusterScienceDays. Way to go Jimbo!
We identified a #VHH antibody that allosterically inhibits sialic acid binding by the #TRAP transporter #SBP VcSiaP. Thanks to the team including: @philipphendricks.bsky.social @scbinder.bsky.social @gavinhthomas.bsky.social @gha14.bsky.social Read the full story here: doi.org/10.1038/s420...
Allosteric substrate release by a sialic acid TRAP transporter substrate binding protein - Communications Biology
Biophysical and structural characterization of the TRAP transporter SBP SiaP in complex with a nanobody provides insights into an allosteric mechanism of inhibition.
doi.org
Substrate binding proteins and nanobodies - that’s protein biochemistry heaven. In our new publication we characterized a nanobody that allosterically inhibits the SBP VcSiaP. Amazing job by @nschneberger.bsky.social and thanks to everyone involved! As always a great team effort! rdcu.be/d1foN
Allosteric substrate release by a sialic acid TRAP transporter substrate binding protein
Communications Biology - Biophysical and structural characterization of the TRAP transporter SBP SiaP in complex with a nanobody provides insights into an allosteric mechanism of inhibition.
rdcu.be
A few more letters... and we can finally write amino acid sequence with protein structure encoded by amino acid sequence? 🧬🤔😀 @chrisfrank662.bsky.social , Dominik Schiwietz, Lara Fuss, Hendrik Dietz www.biorxiv.org/content/10.1...
Really happy to share our latest work in its final form in @jgenphysiol.bsky.social on the characterisation of a TAXI TRAP binding protein from V. cholerae. shorturl.at/88tdH This work was led by SoCoBio DTP student Joe Davies (not on Bluesky yet) and was really fun to work on.
Structure and selectivity of a glutamate-specific TAXI TRAP binding protein from Vibrio cholerae | Journal of General Physiology | Rockefeller University Press
Bacterial TAXI-TRAP transporters are widespread but poorly understood. Davies et al. characterize a TAXI from Vibrio cholerae, revealing its glutamate spec
rupress.org
Newest paper from the Reyme Herman on a Staphylococcal peptidase which we found is involved in the production of thioalcohol-based body odour in human. Continuing our long collaboration with Unilever www.jbc.org/article/S002...
Identification of a staphylococcal dipeptidase involved in the production of human body odor
The production of human body odor is the result of the action of commensal skin bacteria, including Staphylococcus hominis, acting to biotransform odorless apocrine gland secretions into volatile chem...
jbc.org
If you work on bacterial immune systems, this founding paper by Burroughs and Aravind is a must-read (and must-cite). pubmed.ncbi.nlm.nih.gov/32868406/
This is the first fully open source release of a AF3 like model. Awesome! Congratulations to the team.
Gabriele Corso@gcorso.bsky.social · 2y agoThrilled to announce Boltz-1, the first open-source and commercially available model to achieve AlphaFold3-level accuracy on biomolecular structure prediction! An exciting collaboration with Jeremy, Saro, and an amazing team at MIT and Genesis Therapeutics. A thread!
Important paper - just imagining the possibilities if bacteria sense phage infection in neighbours
Cameron Thrash@jcamthrash.bsky.social · 2y agoMetabolites from intact phage-infected Synechococcus chemotactically attract heterotrophic marine bacteria www.nature.com/articles/s41... #jcampubs
New paper from the lab, expanding our work on bacterial AT3's using DALI/FoldSeek to provide the first solid structural evidence to support a Transmembrane Acyl Transferase (TmAT) superfamily of membrane-bound enzymes in all three domains of life. www.biorxiv.org/content/10.1...
Structural unification of diverse membrane-bound acyltransferases reveals a conserved fold that defines the Transmembrane Acyl Transferase (TmAT) superfamily
The movement of acyl groups across biological membranes is essential for many cellular processes. One major family of proteins catalysing this reaction are the acyl transferase family 3 (AT3) proteins...
biorxiv.org
Yesterday my student Niels Schneberger successfully defended his PhD thesis! Congratulations Niels and thanks for everything. What a journey!
