Glennis Logsdon
@glennislogsdon.bsky.social
Assistant Professor of Genetics and Core Member of the Epigenetics Institute at UPenn | T2T, HPRC, and HGSVC member | Loves genomics, epigenomics, and synthetic biology | logsdonlab.com
The discovery of the first kinetochore proteins (CENP-A, CENP-B, CENP-C) was reported by Bill Earnshaw and Naomi Rothfield in 1985 in Chromosoma. Forty years later, Chromosoma/Chromosome Research has published a special issue (most articles are open access) link.springer.com/collections/...
40 years of CENP-A
In 1985, Earnshaw and Rothfield published in Chromosoma a landmark discovery of the centromere-specific protein CENP-A. Subsequent research has shown that ...
link.springer.com
Human acrocentric chromosome short arm de novo mutation and recombination https://www.biorxiv.org/content/10.64898/2025.12.16.694519v1
Absolutely thrilled to share the latest work from my lab focused on the variation and evolution of human centromeres among global populations! We assembled 2,110 human centromeres, identifying 226 new major haplotypes and 1,870 α-satellite HOR variants. www.biorxiv.org/content/10.6...
It's exciting to see the continuing legacy of T2T sequencing methods being discussed on @scifri.bsky.social ! 🧬 Complete genomes are helping us understand more and more about genetic function and diversity in areas of our DNA that were unreadable just a few years ago.
Adam Phillippy@aphillippy.bsky.social · last yr.Complete genomes alert! @glennislogsdon.bsky.social, @christinebeck.bsky.social, and I were on @scifri.bsky.social today talking about "Complex genetic variation in nearly complete human genomes" 📄 www.nature.com/articles/s41... 📻 www.sciencefriday.com/segments/65-...
This was both fun and terrifying to tape! Awesome to talk with @glennislogsdon.bsky.social and @aphillippy.bsky.social about our sequencing data / paper, the improvements to large-scale sequencing projects, and what this means for our understanding of our DNA!
Adam Phillippy@aphillippy.bsky.social · last yr.Complete genomes alert! @glennislogsdon.bsky.social, @christinebeck.bsky.social, and I were on @scifri.bsky.social today talking about "Complex genetic variation in nearly complete human genomes" 📄 www.nature.com/articles/s41... 📻 www.sciencefriday.com/segments/65-...
Complete genomes alert! @glennislogsdon.bsky.social, @christinebeck.bsky.social, and I were on @scifri.bsky.social today talking about "Complex genetic variation in nearly complete human genomes" 📄 www.nature.com/articles/s41... 📻 www.sciencefriday.com/segments/65-...
65 Genomes Expand Our Picture Of Human Genetics
Researchers closely examined the genomes of 65 individuals to paint a more complex, and more complete, picture of human genetic diversity.
sciencefriday.com
Telomere-to-telomere DNA sequencing is set to transform the field of human genetics in coming years. For a flavour of what's coming, see this exciting work on nearly complete genomes of 65 individuals from diverse populations, out today in @nature.com by @glennislogsdon.bsky.social & colleagues. 👇🧬🧪
Complex genetic variation in nearly complete human genomes - Nature
Using sequencing and haplotype-resolved assembly of 65 diverse human genomes, complex regions including the major histocompatibility complex and centromeres are analysed.
nature.com
🚨New preprint out! 🧬Short reads can now decode centromeres. 🌍We reveal population-scale centromere haplogroups and their links to disease. biorxiv.org/content/10.1... (1/n)
Rare k-mers reveal centromere haplogroups underlying human diversity and cancer translocations
Centromeres are among the most diverse and dynamically evolving regions of the human genome and are commonly affected in various human cancers. However, organized into highly repetitive α-satellite hi...
biorxiv.org
We updated our preprint describing chr21 centromere genetics/epigenetics in families with Down syndrome and general population! We found transgenerational methylation changes in a subset of families and that centromere size asymmetry is exclusive to T21! www.biorxiv.org/content/10.1...
Congratulations to @glennislogsdon.bsky.social (@penngenetics.bsky.social/ @pennepigenetics.bsky.social) on being named a 2025 Searle Scholar! tinyurl.com/ma4sp577
ModDotPlot preprint is now out! Winner of best poster at RECOMB 2023, it can generate either static or interactive dotplots in minutes using hierarchical modimizers. With @alexsweeten.bsky.social and @mikeschatz.bsky.social Preprint: www.biorxiv.org/content/10.1... Code: github.com/marbl/ModDot...
Animated GIF - Find & Share on GIPHY
Discover & share this Animated GIF with everyone you know. GIPHY is how you search, share, discover, and create GIFs.
media.giphy.com
Out in Nature from @glennislogsdon.bsky.social. Amazing work on human centromeres and their evolution! www.nature.com/articles/s41...
The variation and evolution of complete human centromeres - Nature
A comparison of two complete sets of human centromeres reveals that the centromeres show at least a 4.1-fold increase in single-nucleotide variation compared with their unique flanks, and up to 3-fold...
nature.com
We demonstrate a single-platform solution for complete T2T genomes on the ONT PromethION: Duplex + Ultra-long + Pore-C, aka "TNT" 🧨 Expecting rapid improvements in the coming year. Congrats @sergek.bsky.social @zbao.bsky.social @awngs.bsky.social @awngs.bsky.social @khmiga.bsky.social et al.!
bioRxiv Bioinfo@biorxiv-bioinfo.bsky.social · 2y agoGapless assembly of complete human and plant chromosomes using only nanopore sequencing https://www.biorxiv.org/content/10.1101/2024.03.15.585294v1
Thank you for the warm welcome, @nucleosomepolice.bsky.social! So excited to be on this platform with amazing and inspiring scientists like yourself!
Karolin Luger@nucleosomepolice.bsky.social · 2y agowelcome to blue @glennislogsdon.bsky.social. If you want to stay updated on the amazingly weird organization of the centromere in all kinds of chromosomes and organisms, follow the new U Penn superstar faculty🧪