RNA-seq tells us how much RNA is present in the cell. But to understand gene regulation, we need to easily measure the synthesis and decay rates driving this abundance. We introduce AIR-seq: analog intrinsic recoding sequencing. (1/6) www.biorxiv.org/content/10.6...

Analog intrinsic recoding measures RNA dynamics without chemical conversion

Steady-state RNA abundance measurements mask the synthesis and decay rates that shape gene expression. Analog intrinsic recoding sequencing (AIR-seq) repurposes the base-pairing properties of N4-hydro...

biorxiv.org

Except the malignant ones! 😱

Fred Hutch@fredhutch.org · last wk.

In case you need a little pick-me-up to start your week, courtesy of Fred Hutch’s Human Biology Division. 🔬🧫🤗

the most realistic scene in Jurassic Park is when two scientists make a questionable decision — traveling to an undisclosed location with a strange man — on the promise of three years of modest funding

THE MYELOID WORKSHOP IS ON! We listened to your feedback and packed more talks in; will start 1 hr earlier. The ASH website will list workshops soon, stay tuned for how to request speaking slots @steidluli.bsky.social

Could Excel be conscious? We surveyed more than Jan 1 1900 people to find out.

The word "honorific" and "horrific" are too close together. Who designed this language?

Excited to share our latest preprint on AML, now on bioRxiv - biorxiv.org/content/10.6... A🧵

Disrupting a Convergent Acetylation Circuit Collapses Leukemic Identity Across AML Subtypes

Acute myeloid leukemia (AML) cells rely on an actively maintained, chromatin-encoded transcriptional program to sustain their malignant identity, offering a potential therapeutic vulnerability. Using ...

biorxiv.org

I'm a fan of Post Malone's early music. When he was Pre Malone.

🚨🚨NEW PREPRINT ALERT!🚨🚨Proud to present our recent study, out now on bioRxiv, in which we reveal an RNA-dependent positive feedback loop that drives malignant ribosome biogenesis and tumour growth (1/15). 🔗 www.biorxiv.org/content/10.6...

I am excited and proud to be an organizer of this fantastic meeting. I always walk away with new friends and colleagues and having learned so much. Hope to see you there!

EMBL Events@events.embl.org · last mo.

The abstract submission deadline for #EESRNA is only a week away! Don't miss your chance to present your research at the EMBO | EMBL Symposium 'The complex life of RNA', the central event for the RNA community. Submit your abstract by 7 July: s.embl.org/ees26-12-bl #RNA #RNAbiology

A deeper dive into the article we published last week in @nature.com. I will start with the framing and methodology as they are key to understanding the surprising results: Most proteomics experiments begin with an assumption. www.nature.com/articles/s41... 1/

What I like about preprints: They don't come with any baked-in impact-factor-like imprimatur that elevates some over others. What would be valuable: An AI-based system that learns a user's scientific questions, and converts the firehose of preprints into a gentle, personally-curated stream.

Biting satire about our increasing reliance on LLMs! 😳

Opinion: I Was Not Allowed To Type Prompts Into ChatGPT During My Chalk Talk And This Is Discrimination

By Dr. Rachel Simmons, Postdoctoral Fellow, Stanford University

inpreparation.substack.com

(1/n) Very excited to share tri-lab collab (Mirny & Zechner) led by Harvey, Henrik & Jack: Q: How do enhancers & promoters interact in space (contact vs. action-at-a-distance) and time (stable vs. transient)? A: Transient E-P contact (~25-42 nm lasting ~10-20 sec): www.biorxiv.org/content/10.6...

My nine year old asked for a Rosetta Stone cake for his birthday

The 2026 Rousseeuw Prize for Statistics has been awarded to the R Project. #RStats www.rousseeuwprize.org/2026

I am deeply honoured to be a laureate of the 2026 Rousseeuw Prize, which has been awarded to the R Project. I have been on the R Core Team for almost 30 years, We built and maintained R with a vision to make statistical tools freely available and extendable. Congratulations to entire team!

The R Foundation@r-foundation.bsky.social · 2mo ago

The 2026 Rousseeuw Prize for Statistics has been awarded to the R Project. #RStats www.rousseeuwprize.org/2026

Had a nightmare that I triple-booked inpatient clinical service with a university lecture and a PhD thesis committee defense, and became aware of the conflicts the night before! Now I'm awake and relieved this wasn't real, but have a fresh new anxiety that I might do this some day! 😅

1/3 Delighted to have visited the University of Pennsylvania this week, hosted by the fantastic Dr. Bobby Bowman who has built an exciting research program on the origins of myeloid malignancies and leukemia relapse.

🧵 NEW PAPER in @bloodjournal.bsky.social! Why do IDH1 mutations almost exclusively drive myeloid #leukemia, while IDH2 mutations occur in both myeloid AND lymphoid cancers? 🤔 #AML #Epigenetics Despite sharing the same biochemical mechanism, they are NOT equivalent. Here's what we found 👇

What's your standard practice in methods sections for standardized, identical protocols (basic techniques like western blotting, PCR, etc)? How do you avoid text duplication and self-plagiarism across multiple manuscripts? Also, journals discourage saying "as previously described..."

Excited that our paper describing a phase 1 trial of ducabtagene autloeucel, a rapidly manufactured anti-BCMA CAR-T in r/r multiple myeloma, was published. #ScienceTranslationalMedicine Huge thanks to all my co-authors, the teams at @danafarber.bsky.social and Novartis, and to our patients.

Efficacy and safety of durcabtagene autoleucel in a phase 1 trial for patients with relapsed/refractory multiple myeloma

Durcabtagene autoleucel, a rapidly manufactured BCMA-directed CAR T cell therapy, was safe and efficacious in relapsed/refractory multiple myeloma.

science.org

YOU’RE LISTENING TO SISYPHUS FM, THE HOME OF NON-STOP ROCK

pronouncing nutella with a spanish ll

If one can stop being careLESS and become careFUL, then why can't I become reckFUL?

Important announcement!!! 💫 Would you have a tooth pulled if it helped your chances to get an important grant funded? Absurd question, but the funding situation is so bad, that I bet some of you actually considered it for a second… keep your teeth! we created something that might help! 👇 (1/16)

Last week, a gentleman returned this rather dilapidated copy of this famous book to us after 50 years. He had found it in his attic! Presumably this means there is a pristine copy somewhere in our libraries....

Can we please stop calling it "The Central Dogma"? What an odd term that was in the first place... And why are we still using it in the 21st century...?

Proud to share our latest paper in @rscchembio.rsc.org, where we tackle oncogenic TRK fusions. Together, @sauravk05.bsky.social and Jiewei Jiang develop potent and selective degraders of the TPM3-TRKA fusion, a key cancer driver. pubs.rsc.org/en/content/a...

Development of PROTACs for targeted degradation of oncogenic TRK fusions

Chromosomal translocations leading to the fusion of tropomyosin receptor kinases (TRKs) with diverse partner proteins have been identified as oncogenic drivers in many adult and pediatric cancers. Whi...

pubs.rsc.org

Very proud of Samantha "S" Fallacaro the first student from our lab to defend their thesis! Check out her latest work (tinyurl.com/42hdfssz) where she shows that "hubs" formed by the transcription factor Dorsal are emergent features of binding kinetics, not higher-order regulatory assemblies.