The swifts of St Catharine's College, noisy blighters 🥰
Glenn Masson
@glennmasson.bsky.social
Scientist at School of Medicine, University of Dundee. Using cryo-EM and my beloved HDX-MS to investigate all things ISR Kinase - GCN2, HRI, PERK (and I guess PKR). https://glennmasson.com
A lovely wee review from a very talented PhD student Min Cao, with whom I share supervision duties with Miratul Muqit, is out today on HRI. Turns out, despite knowing about HRI for about 70 years, it still has the capacity to surprise! portlandpress.com/biochemsoctr...
Structural insights into HRI kinase activity and inhibition
Abstract. Haem-regulated inhibitor (HRI) is emerging as a potential therapeutic target in several disease areas, including cancers such as multiple myeloma and neurodegenerative disease. As one of fou...
portlandpress.com
UKRI urged to be ‘transparent’ after adopting grant lotteries. Funder’s quiet introduction of randomisation option across opportunities prompts questions, plus support for “innovative” action. www.researchprofessionalnews.com/rr-news-uk-r...
UKRI urged to be ‘transparent’ after adopting grant lotteries - Research Professional News
Funder’s quiet introduction of randomisation option across opportunities prompts questions, plus support for “innovative” action
researchprofessionalnews.com
New paper alert! Residue level Kd's from HDX-MS/MS data published today in JASMS. Really useful approach to disentangle drug/protein SAR on proteins in solution in a medium throughput way. Great work De Lin, Vincent Postis and every who helped! pubs.acs.org/doi/10.1021/...
Residue-Level Determination of Small-Molecule–Protein Affinities by Hydrogen–Deuterium Exchange Mass Spectrometry
Hydrogen–Deuterium Exchange Mass Spectrometry (HDX-MS) is an established tool in drug discovery, used to characterize target engagement and conformational dynamics, and frequently used in both biophar...
pubs.acs.org
@newstatesman1913.bsky.social hey , either my maths isn't what it used to be....does the annual subscription come with a complimentary Nick Lezard fag stained signed tote bag or something?
Nowruz mubarak from this adopted Iranian to the people of Iran and the Iranian diaspora. Fesenjān, sabzi polo, ghormeh sabzi and kebab to celebrate the new year.
Had a wonderful time in Strasbourg presenting our latest HDX-MS research at the 5th International Conference for HDX! Excellent cheese, beer, wine, macarons and outstanding science to boot! Excellent work from the conference organisers Sarah, Julien and Cherine!
🚨⚠️ New Preprint Alert! ⚠️ 🚨 www.biorxiv.org/content/10.6... Screening p97 cofactors, @prithadg.bsky.social identified FAF2 as the strongest activator of the p97-UFD1-NPL4 complex. Leveraging her mechanistic descoveries, we designed 𝘥𝘦 𝘯𝘰𝘷𝘰 binders that could also enhance p97 substrate unfolding.
Please spread the word: the Structural Studies Division @mrclmb.bsky.social is looking for a new tenure-track, independent group leader with an exciting plan in any area of Structural (Molecular & Cell) biology, in discovery biology and/or methods development. 🥳 mrc.tal.net/vx/mobile-0/...
Research Group Leader Tenure Track - Structural Studies - LMB 2775 - Medical Research Council
Location: Cambridge. Vacancy: Research Group Leader Tenure Track - Structural Studies - LMB 2775. Closing Date: 16/03/2026, 23:55
mrc.tal.net
Fellowship rejected (after interview), root canal, and a -80 freezer failure all within 24h. Yay!
Another day another birthday party. The brief for this one was rainbow marshmallow sprinkles and I think I achieved that. Now for the ensuing hyperglycemic coma...
I watched much of Ian Chapman's (Head of @ukri.org) appearance this morning at @ukparliament.parliament.uk Science, Innovation and Technology Committee.. A few points and new information that bioscientists may find interesting... A 🧵
! 🧐 chemrxiv.org/doi/full/10....
Site Specific Hydrogen Deuterium Exchange Mass Spectrometry Enables Deep Explorations of Dynamic Allosteric Networks in Protein-Drug Interactions | ChemRxiv
If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download.For more information or tips please see 'Downloading to a citation manager' in the Help menu.
chemrxiv.org
Exciting opportunity for a #postdoc to join @suyangzhang.bsky.social’s group in the LMB Structural Studies Division to investigate co-transcriptional splicing using cryo-EM and biochemistry. Read more: www.nature.com/naturecareer... Apply by 11 FEB #PostdocJobs #ScienceJobs
Nothing will make Universities flee from embracing and embedding AI faster than sharing IP % points lol
Ian Fay@ianfay.bsky.social · 6mo agoLmao the bubble is fit to burst, boys This is a hysterical and insane choice, I hope they follow through!
Please share! We've an exciting one-year postdoctoral position available in my group - drug discovery using HDX-MS for a Parkinson's disease target. Join us on high-impact, translational research at the cutting edge of structural biology. We're a friendly bunch! www.dundee.ac.uk/work-for-us/...
Postdoctoral Research Assistant - UOD2127
Closing date: Wednesday 18 February 2026, 23:59
dundee.ac.uk
Want to get the data out of a PDF figure? As in, the actual data – not a rough trace-along-the-lines version? I made an app you might like: adamkucharski.github.io/pdf2plot/ It all started a few years ago... 🧵
Structural basis for a phosphoinositide-driven mTORC2-AKT positive feedback loop https://www.biorxiv.org/content/10.64898/2026.01.08.698367v1
Pssst! I have a PhD position available. Please pass it on www.findaphd.com/phds/project...
Exploring Resistance to KRAS inhibitors (KRASi) of differentiated Mechanism of Action at Babraham Institute (Cambridge) on FindAPhD.com
PhD Project - Exploring Resistance to KRAS inhibitors (KRASi) of differentiated Mechanism of Action at Babraham Institute (Cambridge), listed on FindAPhD.com
findaphd.com
PXD053875 🚨 Cyclophilin D (CypD) is a drug-target protein ligand that can be pushed to fHDX-MS in the double-digit mM range. This study proposes a methodological framework for FBDD. 🚨 New dataset alert! 🚨
Reviewing a x-ray crystallography paper, I have asked for the .mtz file, as they talk quite a bit about the density supporting their findings. Authors have refused. Am I out of touch w/ x-ray data now or is that kind of insane? #crystallography @markohyvonen.bsky.social @scurry.bsky.social
Waking up to a morning of awkward looks and disappointment every morning...this Ashes series is like Christmas day on repeat.
A wonderful opportunity to be part of the friendliest college in Cambridge! A JRF is a wonderful springboard to academic independence
St Catharine's College@stcatharines.bsky.social · 8mo agoOur next Junior Research Fellowship is open to early career researchers engaged in any aspect of: Applied Mathematics & Theoretical Physics, Biological Sciences, Medical Sciences, Physics or Veterinary Sciences. Find out more and apply by 12 December:
I’m really pleased to share the link to a new Cook Lab paper published today in Nature Communications. www.nature.com/articles/s41...
RAF inhibitors activate the integrated stress response by direct activation of GCN2 - Nature Communications
Three BRAF inhibitors are used to treat melanoma and colorectal cancer. Here, the authors demonstrate that these drugs bind and activate the protein kinase GCN2, a previously unappreciated off-target ...
nature.com
📢New preprint has landed! 📢 We show how HDX-MS can derive Kd at AN AMINO ACID RESOLUTION using HDX-MS against drugs. Comments and criticisms welcome! Spatially Resolved Determination of Small Molecule Protein Affinities by HDX-MS. www.biorxiv.org/content/10.1...
Spatially Resolved Determination of Small Molecule Protein Affinities by Hydrogen Deuterium Exchange Mass Spectrometry
Hydrogen Deuterium Exchange Mass Spectrometry (HDX-MS) is an established tool in drug discovery, used to characterize target engagement and conformational dynamics, frequently used in both biopharmace...
biorxiv.org
