Microbial metabolite p-cresol associates with constipation in adults with high-functioning autism spectrum disorder and induces constipation-like symptoms in mice - Scientific Reports

Scientific Reports - Microbial metabolite p-cresol associates with constipation in adults with high-functioning autism spectrum disorder and induces constipation-like symptoms in mice

nature.com

Des scientifiques parviennent à créer des organoïdes intestinaux plus grands et dotés d’un système nerveux fonctionnel - Salle de presse de l'Inserm

De plus en plus de personnes souffrent de maladies gastro-intestinales. Pour mieux comprendre ces pathologies et apporter des solutions aux patients, les scientifiques travaillent sur les organoïdes, ...

presse.inserm.fr

Brain and Body Communication in Health and Disease

In this cross-journal Collection we invite submissions of basic, pre-clinical, and clinical studies focusing on the bidirectional communication between the ...

nature.com

Baby-to-baby strain transmission shapes the developing gut microbiome - Nature

A metagenomic survey of babies attending the first year of nursery detected extensive baby-to-baby microbial strain transmission, pointing to social interactions in infancy as crucial drivers of infan...

nature.com

gutSMASH 2.0: Extended Identification of Primary Metabolic Gene Clusters From the Human Gut Microbiota

Microbiota-derived metabolites serve as key messengers mediating host–microbe and microbe–microbe interactions, often through specialized primary meta…

sciencedirect.com

The Biodiversity Cell Atlas: mapping the tree of life at cellular resolution - Nature

The Biodiversity Cell Atlas aims to create comprehensive single-cell molecular atlases across the eukaryotic tree of life, which will be phylogenetically informed, rely on high-quality genomes and use...

nature.com

Faecal metabolites as a readout of habitual diet capture dietary interactions with the gut microbiome - Nature Communications

Here, by integrating faecal metabolomics, metagenomics, and habitual dietary data of two large human cohorts, the authors show that faecal metabolites reflect diet and gut microbiome interactions, pre...

nature.com

Local B cell maturation and mast cell regulation of choroid plexus function in early life.

Postnatal development is a critical period for the maturation of the nervous and immune systems. The choroid plexus (CP) within the brain ventricles guides brain development through the production of ...

biorxiv.org

The gut microbiome shapes social behaviour across animal species

Nature Reviews Microbiology, Published online: 14 November 2025; doi:10.1038/s41579-025-01262-yThe gut microbiome can influence brain activity and complex behaviours. In this Review, Griffiths et al. discuss microbiome-associated effects on social behaviour in laboratory model organisms, free-living animals and humans, and consider potential mechanistic pathways.

nature.com

The autism-linked gut microbial metabolite p-cresol inhibits host catecholamine biosynthesizing enzymes to elicit social deficits - Communications Biology

The microbial metabolite p-cresol and p-cresol sulfate accumulate in brainstem and inhibit TH and DBH, key enzymes in catecholamine synthesis. This disruption alters brain function and behavior, ...

nature.com

Socially parasitic ant queens chemically induce queen-matricide in host workers

Taku Shimada and colleagues show that socially parasitic queens of two ant species spray their respective host queens with chemical signals that trigger host workers to kill the resident queen.

cell.com

Induction of menstruation in mice reveals the regulation of menstrual shedding

During menstruation, an inner layer of the endometrium is selectively shed, while an outer, progenitor-containing layer is preserved to support repeated regeneration. Progress in understanding this co...

biorxiv.org

Unlocking the power of human milk and infant feeding: Understanding how nutrition and early microbiota interaction shapes health programming

Infant feeding plays a crucial role in microbial colonization, immune maturation, and development. Human milk is a bioactive system comprising biologics that shape the infant gut microbiome and suppor...

cell.com

Adaptive radiation and social evolution of the ants

Comparative analyses of 163 ant genomes reveal extensive genome rearrangements, context-specific gene family expansion patterns, and selection on conserved pathways that together underpin the evolutio...

cell.com

Gut microbiota diversity affects fish behaviour and is influenced by host genetics and early rearing conditions | Open Biology

The gut microbiota influences human and animal cognition and behaviour through its effects on the endocrine and immune systems. The microbiome–behaviour relationship may be especially relevant for fish, due to their diverse evolutionary history and ...

royalsocietypublishing.org

The origin of vertebrate teeth and evolution of sensory exoskeletons - Nature

Re-examination of the presumed Cambrian fossil fish Anatolepis reveals previous misidentification of aglaspidid sensory structures as dentine, a vertebrate sensory tissue, showing it to be a...

nature.com

Dominance rank inference in mice via chemosensation

Borak et al. reveal that male mice can infer the dominance status of unfamiliar opponents using scalable chemosensory cues. Sensory ablation experiments demonstrate that both olfactory and vomeronasal...

cell.com

Perinatal exposure to the autism-linked metabolite p-Cresol has limited impact on early development in mice but lasting effects on adult social behavior - Scientific Reports

Scientific Reports - Perinatal exposure to the autism-linked metabolite p-Cresol has limited impact on early development in mice but lasting effects on adult social behavior

nature.com

Sensory input, sex and function shape hypothalamic cell type development - Nature

Paired transcriptomic and chromatin accessibility profiling are used to examine the developmental trajectories of neuronal populations in the hypothalamic preoptic region, including cell types with ke...

nature.com

Sensory input, sex and function shape hypothalamic cell type development - Nature

Paired transcriptomic and chromatin accessibility profiling are used to examine the developmental trajectories of neuronal populations in the hypothalamic preoptic region, including cell types with ke...

nature.com

A hypothalamic circuit underlying the dynamic control of social homeostasis - Nature

New data on brain-wide circuits centred around two interconnected hypothalamic neuron populations provide significant mechanistic insights into the emergence of social need during social isolation and...

nature.com

Dietary availability acutely influences puberty onset via a hypothalamic neural circuit

Goto et al. measure the pulsatile activity of the reproductive center in the hypothalamic arcuate nucleus during puberty in female mice. They discover that food availability rapidly and bidirectionall...

cell.com

History – The Long-Term Evolution Experiment

the-ltee.org

Evidence for Endogenous Collagen in Edmontosaurus Fossil Bone

Reports of proteins in fossilized bones have been a subject of controversy in the scientific literature because it is assumed that fossilization results in the destruction of all organic components. In this paper, a novel combination of analytical techniques is used to address this question for an exceptionally well-preserved Edmontosaurus sacrum excavated from the Upper Cretaceous strata of the South Dakota Hell Creek Formation. Cross-polarized light microscopy (XPol) shows birefringence consistent with collagen presence. Tandem LC-MS unambiguously identified, and for the first time quantified, hydroxyproline, a unique collagen-indicator amino acid, in acid-digested samples from the Edmontosaurus. LC-MS/MS bottom-up proteomics shows identical collagen peptide sequences previously identified and reported for another hadrosaur and a T. rex sample.

pubs.acs.org

The microbiota-derived bile acid taurodeoxycholic acid improves hepatic cholesterol levels in mice with cancer cachexia

Alterations in bile acid profile and pathways contribute to hepatic inflammation in cancer cachexia, a syndrome worsening the prognosis of cancer patients. As the gut microbiota impinges on host me...

tandfonline.com

Self-experience of a negative event alters responses to others in similar states through prefrontal cortex CRF mechanisms - Nature Neuroscience

Maltese et al. show in mice that experiencing an adverse event affects future interaction with others experiencing the same stressor. These self-experience socioemotional reactions are orchestrated by...

nature.com

Roseburia intestinalis-derived butyrate alleviates neuropathic pain

Jiang et al. identified distinct gut microbiota profiles in healthy individuals and patients with shingles or postherpetic neuralgia (PHN). They developed a metagenomics-based model to assess PHN risk and showed that Roseburia intestinalis produces butyrate to alleviate pain by activating vagal nerves, suppressing pain-related brain regions in animal models.

cell.com