Aleksandra Deczkowska
@adeczkowska.bsky.social
Busy @aleksdelab.bsky.social @pasteur.fr || single cells and neuro-immune stuff II #firstgen #ally🏳️🌈🏳️⚧️
"Explaining something with the wrong model can be worse than not explaining it at all." www.nature.com/articles/s41...
On the balance of knowledge - Nature Reviews Immunology
Ruslan Medzhitov shares his thoughts on the balance between generating data and developing theories in immunology, with a focus on exploring the rules that govern complex systems.
nature.com
🎙️ Morgane THION, Collège de France, will talk about "microglia in the developing brain: from colonization to functions" on Monday, 9 February, at 11am at Paris Brain Institute. 👉 More information: https://parisbraininstitute.org/agenda/scientific-lectures-morgane-thion
Scientific lectures: Morgane THION | Paris Brain Institute
Speaker : Morgane THION, College de France"Microglia in the developing brain: from colonization to functions"
parisbraininstitute.org
What if the immune system held a key to brain health ? 🧠 Research by Aleksandra Deczkowska @adeczkowska.bsky.social at the Institut Pasteur shows constant immune–brain dialogue, and how modulating immunity could help prevent or treat neurological diseases.
Tumor-associated macrophages directly stimulate neurite outgrowth, revealing a dual role in enhancing intratumoral nerve growth and promoting neural repair after severe spinal cord injury @cp-immunity.bsky.social www.cell.com/immunity/ful...
Why do so few cancer cells manage to form metastases - and what helps the rare ones succeed? Delighted to share our first publication of 2026 🎉🎉, led by the outstanding @lbejarano.bsky.social 🤩, where we reveal some insights into this - focusing on brain metastasis 🧠🧪🔬 www.cell.com/cell-reports...
A researchers’ propensity for risky projects is passed down to their doctoral students — and stays with trainees after they leave the laboratory go.nature.com/4qvaffO
PhD students’ taste for risk mirrors their supervisors’
Nature - Learned risk-taking behaviours can persist for years after leaving the lab — and even after taking on a new research topic.
go.nature.com
Multidisciplinary training, over time, produces the highest impact people www.science.org/doi/10.1126/...
Recent discoveries on the acquisition of the highest levels of human performance
Scientists have long debated the origins of exceptional human achievements. This literature review summarizes recent evidence from multiple domains on the acquisition of world-class performance. We re...
science.org
Microbes weaponizing secondary metabolites to make rivals vulnerable to phage attack 🧪🦠 www.nature.com/articles/s41...
Streptomyces secretes a siderophore that sensitizes competitor bacteria to phage infection - Nature Microbiology
A secondary metabolite sensitizes competitor Bacillus subtilis to a wide panel of lytic phages by sequestering iron and preventing the activation of Spo0A.
nature.com
This #Preprint reports that B6 (but not wild mice) have a truncated PDL2, missing an active intracellular signalling domain: "Surprisingly, in C57BL/6J (B6) mice PD-L2 has only a 5-amino acid intracellular domain, and the same is true for several other laboratory mouse strains" #Immunology
PD-L2 Regulates Natural Antibody and IL-10 Secretion by B-1 cells
B-1 cells are innate-like lymphocytes that play a critical role in homeostasis by secreting natural antibodies, typically IgM, and immunosuppressive molecules such as IL-10. However, the regulation of...
biorxiv.org
I am thrilled to share our latest work led by @zurisullivan.bsky.social in collaboration with @moffittlab.bsky.social ! We find that the brain encodes distinct, pathogen-specific sickness states across behavior, physiology, neural activity, and gene expression 1/6 www.biorxiv.org/content/10.6...
biorxiv.org
Come to be our colleague! Center of Paris, excellent facilities, research spanning the whole range of basic and biomedical life science topics, enthusiastic and collaborative colleagues, crème brûlée every Friday... What else could one want?
Institut Pasteur | 130 years of biomedical research@pasteur.fr · 9mo ago🔬 Call to create junior research groups at the Institut Pasteur Focus: Infectious diseases, host-microbe interactions, vaccines Special interest: AI methodologies 📅 Deadline: Feb 9, 2026 👥 2-12 years post-PhD Apply now 📝 research.pasteur.fr/en/call/crea... #JobOpportunity #Research
🔬 Call to create junior research groups at the Institut Pasteur Focus: Infectious diseases, host-microbe interactions, vaccines Special interest: AI methodologies 📅 Deadline: Feb 9, 2026 👥 2-12 years post-PhD Apply now 📝 research.pasteur.fr/en/call/crea... #JobOpportunity #Research
Creation of new junior research groups at the Institut Pasteur - Call for applications 2026 - Research
The Institut Pasteur is launching an international call to recruit new junior research group leaders leveraging cutting-edge transdisciplinary approaches to exploring infectious diseases, host-microbe...
research.pasteur.fr
Evidence continues building that oxidized lipids drive inflammasome activities in health and disease. A beautiful study shows a link to multiple sclerosis, with a role for inflammasomes and IL-1 in pathology. Kudos to the authors on this exciting discovery. www.nature.com/articles/s41...
Oxidized phosphatidylcholines deposition drives chronic neurodegeneration in a mouse model of progressive multiple sclerosis via IL-1β signaling - Nature Neuroscience
In this study, Yu et al. found that a positive feedback loop between oxidized phosphatidylcholine and IL-1β promotes chronic neurodegeneration in the central nervous system and could be a contributing...
nature.com
Excited to share our new preprint: “Local B cell maturation and mast cell regulation of choroid plexus function in early life” www.biorxiv.org/content/10.1... , initiated in the lab by Laetitia Travier and led by the one and only @fakesamir.bsky.social
Local B cell maturation and mast cell regulation of choroid plexus function in early life.
Postnatal development is a critical period for the maturation of the nervous and immune systems. The choroid plexus (CP) within the brain ventricles guides brain development through the production of ...
biorxiv.org
These are the 10 art classroom rules of Corita Kent (artist, teacher, social justice advocate and nun). They are true for any creative process, especially Rule 8: DON’T TRY TO CREATE AND ANALYZE AT THE SAME TIME. THEY’RE DIFFERENT PROCESSES. (i.e. night science / day science).
Early-life stromal niches orchestrate B lymphopoiesis at the brain's borders https://www.biorxiv.org/content/10.1101/2025.11.27.690844v1
Nature research paper: iHALT unlocks liver functionality as a surrogate secondary lymphoid organ go.nature.com/3M7ctmb
iHALT unlocks liver functionality as a surrogate secondary lymphoid organ - Nature
Liver-restricted viral infection in mice results in secondary lymphoid organ dormancy and the compensatory induction of specialized lymphoid tissue in the liver, the structural features and functional outputs of which are closely mirrored in humans.
go.nature.com
Microglial CLEC7A restrains amyloid beta plaque pathology in a mouse model of Alzheimer's disease alz-journals.onlinelibrary.wiley.com/doi/10.1002/... @alzdemjournals.bsky.social
PhD students and Postdocs: The Night Science Podcast (@nightsciencepod.bsky.social) is producing an episode highlighting young scientists talking about their creative process. DM me if you'd like us to consider you for this, & read below what PhD student Davis Garner will contribute! ⬇️
Our work out in @devbiol.bsky.social, PDGFra is needed for 🧠 perivascular fibroblast development... ⬇️ perivascular fibroblast = ⬇️ perivascular macrophage...cross-talk? 👀 Led by Hannah Jones @hejcell.bsky.social w/ Kelsey Abrams, Sophia Kim, excited for more projects w/ @fantauzzolab.bsky.social!
Baptiste Lacoste@blacoste.bsky.social · 10mo agoPDGFRα is required for postnatal cerebral perivascular fibroblast development. Congrats @siegenthalerlab.bsky.social ! #cerebrovascular #fibroblasts #development
A study with data from ~14 million children shows that COVID19 infection is significantly more harmful to kids’ hearts than the vaccine. Marty Makary falsely alleged that “children died” because from COVID19 vaccine. Whomever told him that failed to account for SARS-CoV-2 infections. Link below.
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Evidence continues to accumulate that mRNA can deliver immunostimulatory innate proteins. www.pnas.org/doi/suppl/10...
Happy to share STORIES out now on Nature Methods STORIES learns cell fate landscapes from spatial tramscripromics data profiled at several time points, thus allowing prediction of future cell states. Led by Geert-Jan Huizing and Jules Samaran www.nature.com/articles/s41... @pasteur.fr
STORIES: learning cell fate landscapes from spatial transcriptomics using optimal transport - Nature Methods
By learning a differentiation potential using an optimal transport-based approach, STORIES models and infers cell fate trajectories using spatiotemporal omics data.
nature.com
During Alzheimer’s Disease Awareness Month, we honor the millions of individuals & families affected by Alzheimer’s, and the scientists working tirelessly to change its course. Each new finding increases our understanding of Alzheimer’s and brings us closer to a cure. #AlzheimersAwarenessMonth
Immunology as a guide to human relationships #immunology
Immunology as a guide to human relationships
This essay uses immunology to illuminate human relationships. Moving beyond self/non-self toward danger-based models, it draws parallels between cytokine communication and language, tolerance and forgiveness, microbiota diversity and coexistence. Recognizing these metaphors reveals pathways toward healthier connections within individuals, communities, and societies.
dlvr.it
« … Un Français consomme en moyenne plus de 10 000 animaux au cours de sa vie alors qu’il en utilise indirectement seulement 2,5 en moyenne pour la recherche scientifique et biomédicale … »
Sebastien G Bouret@sebastienbouret.bsky.social · 11mo agoLes extrêmes mettent en danger notre démocratie mais aussi la science et la santé. J’ai cosigné une tribune publiée dans Le Monde aujourd’hui pour dénoncer les amendements LFI/RN visant à taxer l’expérimentation animale car ils constituent une menace pour la recherche et les découvertes médicales 🔬
