Primary mitochondrial-disorders-associated nephropathy in adulthood

Oxidative phosphorylation is the main source of cellular ATP production and depends on proteins encoded by both mitochondrial and nuclear DNA. Pathogenic variants affecting this dual genetic control c...

kireports.org

HBV-associated cryoglobulinemic glomerulonephritis misdiagnosed as lupus nephritis: the value of clinicopathologic integration

Hepatitis B virus (HBV)–associated cryoglobulinemic glomerulonephritis (CryoGN) is an uncommon immune complex–mediated kidney disease that frequently presents with a membranoproliferative glomerulonep...

kireports.org

Lupus Nephritis Susceptibility Loci in the All of Us Research Cohort

Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by loss of tolerance to nuclear antigens.1 More than 25% of individuals with SLE develop lupus nephritis (LN), which is a sign...

kireports.org

A multi-national study examined the response sustainability to calcineurin inhibitors and long-term kidney survivals in children with genetic podocytopathies

While calcineurin inhibitors (CNI) reduce proteinuria in a subgroup of children with genetic podocytopathies, previous reports suggest that the response is short-lived and of no benefit to long-term o...

kidney-international.org

Early Acute T Cell-Mediated Rejection and Kidney Allograft Outcomes

Despite the prevalent notion that early acute T cell-mediated rejection (TCMR) in kidney transplant patients is clinically benign, how it responds to treatment and whether treatment responses impact l...

kidney-international.org

Donor-derived Fat Emboli in a Post-reperfusion Biopsy

A 64-year-old female with chronic kidney disease presumed secondary to hypertension underwent pre-emptive deceased donor kidney transplantation. Medical history was also notable for hyperlipidemia, ob...

kidney-international.org

Non-Lupus Full House Glomerulonephritis Following COVID-19: A Rare Case of DNAJB9- Negative Fibrillary GN

We report a novel case of fibrillary glomerulonephritis (FGN) occurring after COVID-19 infection, presenting as non-lupus full-house immune complex glomerulonephritis and achieving complete renal reco...

kidneymedicinejournal.org

Long-Term Clinical Course of COL4A1-Associated Nephropathy and Assessment of α1 Chain of Type IV Collagen Expression in Kidney Biopsy Specimens: A Case Report

COL4A1 variants cause a spectrum of systemic disorders encompassed by Gould syndrome. While kidney involvement is recognized, its long-term progression and detailed kidney pathology remain uncharacter...

ajkd.org

Non-HLA antibodies worsen the histological phenotype and prognosis of antibody mediated rejection in kidney allografts

Antibody-mediated rejection (AMR) remains a leading cause of kidney allograft failure, with both HLA and non-HLA antibodies implicated in its pathogenesis. The contribution of non-HLA antibodies (non-...

kidney-international.org

Fetal Growth Restriction and Acute Kidney Injury in Children and Young Adults

Fetal growth restriction is associated with reduced nephron endowment, suggesting increased kidney vulnerability across the life course. However, its association with acute kidney injury (AKI) beyond ...

kidney-international.org

A multicenter registry study of the CD38 antibody daratumumab for the treatment of microvascular inflammation following kidney transplantation

Microvascular inflammation (MVI) on kidney biopsy is associated with reduced graft survival following kidney transplantation (KT). CD38- targeting regimens, including the monoclonal antibody daratumum...

kidney-international.org

Kidney allograft outcomes in borderline and T cell-mediated rejection with microvascular inflammation

Microvascular inflammation (MVI) is a hallmark feature of antibody-mediated rejection (ABMR), but its prognostic significance when it occurs with T-cell-mediated rejection (TCMR) in the absence of oth...

kireports.org

Complement-Mediated Postpartum Atypical Hemolytic Uremic Syndrome With Collapsing Focal Segmental Glomerulosclerosis Associated With a Novel CFHR5 Copy Number Variant

Thrombotic microangiopathies (TMAs) that occur during pregnancy or the postpartum period—including preeclampsia/HELLP syndrome (hemolysis, elevated liver enzymes, low platelets), thrombotic thrombocyt...

ajkd.org

Expanding horizons in the management of IgA nephropathy with targeted therapies

It is fair to say that the management of IgA nephropathy (IgAN) is in the midst of a revolution. Although I could have used the word transformation, I think revolution is appropriate and will elaborat...

kisupplements.org

The Case | Podocyte vacuolization and myelin figures in a young male with proteinuria

A 20-year-old man was incidentally found to have 3+ proteinuria on dipstick during routine evaluation. He was asymptomatic, normotensive, and nondiabetic, with preserved renal function (serum creatini...

kidney-international.org

Clinical and histologic predictors of non-diabetic kidney disease in patients with diabetes mellitus

The number of kidney biopsies performed in patients with diabetes has increased rapidly over the last two decades. However, the overall value of the biopsy has been questioned because any coexisting n...

kidney-international.org