10 cups of coffee a day can give you…..a nasty kidney stone www.kidney-international.org/article/S008... in @kidneyint.bsky.social
Juan Carlos Q Vélez, MD
@juancarlosqvelez.bsky.social
🩺 Academic Nephrologist, Ochsner Health, New Orleans, LA, USA 🎓Professor of Medicine, Ochsner Clinical School - The University of Queensland, QLD, Australia 🔬Self-proclaimed Pisse Prophet
Interesting report. But all 4 donors had overt proteinuria at the time of organ allocation. Is it standard procedure to ignore that in deceased kidney donation? Tapping a transplantologist @georginairish.bsky.social @nymurakami.bsky.social #NephSky
Grace Choung, MD 박영이@gracechoung.bsky.social · 5d agoCollapsing Glomerulopathy Encountered in Time Zero Kidney Allograft Biopsies - Kidney International Reports www.kireports.org/article/S246...
Call 📢 for papers: "The Jerry Yee: Clinical Challenges in Diagnosis and Treatment in Nephrology" #Nephpearls #NephSky 🗓️ Deadline for submissions: 15 October 2026 👉 www.sciencedirect.com/special-issu...
🎓 This week we had a key Urinary Sediment course at Hospital Almenara, @albertogs.bsky.social Perú 🇵🇪, backed by ISN @theisn.org and the academic quality of @juancarlosqvelez.bsky.social 🙌 🇵🇪🇺🇲 Grateful for all the knowledge shared. #UrinarySediment #Nephrology #ISN
🚨 New nephSAP issue: Examine current approaches to AKI diagnosis, management, prevention, and treatment in Vol. 25, No. 2, Acute Kidney Injury and Critical Care Nephrology, and hear from the guest editors in the companion podcast. 📖: https://nephsap.org 🎧: https://bit.ly/nephSAPseries
Very excited for this, come down to beautiful Tarapoto in Peru 🇵🇪 to enjoy nature and a few acid-base & electrolyte lectures 💪 9/3-4, 2026.
josephpezo.bsky.social@josephpezo.bsky.social · 7mo agoSave the Date: 03 y 04 de Septiembre, 2026. First International Course on Fluid, Electrolyte and Acid-Base Disorders. Evento Híbrido en 🌴 Bella Terra - Laguna Azul - Resort & Spa. Sauce, San Martín, Perú. 🇵🇪 @juancarlosqvelez.bsky.social @theisn.org Inscripciones 👉🏻 www.kidneycaresanmartin.pe
Love the key inclusion of #UrineMicroscopy to identify glomerular hematuria at the top of the algorithm for hematuria. Best way to avoid unnecessary invasive (cystoscopy) and costly (CT) urological testing #UrinarySediment #NephSky
Mythri Shankar@nephromythri.bsky.social · 2mo agoNew open-access review out now 🧬🔬 “Beyond the Bladder: Recognising Glomerular Hematuria and the Role of Genetic Testing in Clinical Practice” A practical guide for clinicians: when to refer, when to test, and how to counsel patients. 📖 doi.org/10.5528/wjtm... #Nephrology #GeneticTesting
Spectrum of Anti–Factor B-Associated Glomerular Diseases in Adults - American Journal of Kidney Diseases www.ajkd.org/article/S027...
Spectrum of Anti–Factor B-Associated Glomerular Diseases in Adults
Autoantibodies targeting complement factor B (anti-FB) are among the most recently described alternative pathway anomalies. Although they have been strongly associated with post-infectious glomerulone...
ajkd.org
Long curvilinear waxy cast with embedded erythrocytes, many of them dysmorphic; complex case of infection-related C3 #glomerulonephritis + TBMN. #UrinarySediment #UrineMicroscopy #OchsnerNephrology
1/ The photomicrograph shows a glomerulus on PAS stain with mesangial accumulation of homogenous PAS-pale material consistent with amyloid. #renalpath #kidneypath #pathology #renal #pathtwitter
Huge step in the right direction. Serological anti-NELL1 antibodies are necessary to improve the diagnosis and management of NELL1-membranous nephropathy #NephSky
Kidney International@kidneyint.bsky.social · 2mo agoQuantitative serological detection of NELL1 autoantibodies in membranous nephropathy doi.org/10.1016/j.kint.2026.05.017 #MedSky #NephSky #OpenAccess #membranousnephropathy #nephroticsyndrome
Ooh @kidneyint.bsky.social goes there Fast www.kidney-international.org/article/S008... Slow www.kidney-international.org/article/S008... Hyponatremia controversies #NephSky
Hyponatremia treatment guidelines: a necessary course correction
The optimal treatment of hyponatremia has been debated for >50 years. It is now widely accepted that in severe hyponatremia (<120 mmol/L), the rate of correction should not exceed 8 mmol/L per 24 hour...
kidney-international.org
“Doc, I just sent u a link for u 2 create a new username/password. Once u do it, you’ll b able 2 change your old password in the other portal with a new link that will b sent 2 u. Once u r in, u just have 2 initial, date and sign all 367 trial alerts in your dashboard. Should b quick” —-site PI day
Not sure if this is a good idea. @hswapnil.medsky.social
MedPage Today@medpagetoday.com · 2mo agoThe FDA approved a combination tablet of 325-mg acetaminophen and 110-mg naproxen sodium (Tylenol with Naproxen) for over-the-counter pain relief, the agency announced Friday. https://www.medpagetoday.com/neurology/painmanagement/122343
¡Excelente ponencia en el FIC Tarapoto 2026! 🌴🇵🇪 El Dr @juancarlosqvelez.bsky.social nos comparte una muestra sobre fisiología renal. No te pierdas su participación junto a expertos de primer nivel. 🗓️ 03 y 04 Set, 2026 📍 Sauce, San Martín - Perú ¡Inscríbete en el enlace! 👇 www.kidneycaresanmartin.pe
NEW on the #AJKDBlog: @maximalchange.bsky.social interviews Manuel Laslandes and @c-masset.bsky.social on response to rituximab as a maintenance therapy in adults with idiopathic nephrotic syndromes (INS):
Response to Rituximab as a Maintenance Therapy in Adult INS: An Interview
Rituximab effectively limits the number of relapses in childhood idiopathic nephrotic syndromes (INS) and reduces exposure to corticosteroids and other immunosuppressants. However, few data are ava…
bit.ly
Endorse
Swapnil Hiremath 🍁🇨🇦@hswapnil.medsky.social · 3mo agoMedPage Today @medpagetoday.com quotes @brianrifkin.bsky.social et al on CKM guidelines/staging www.medscape.com/s/viewarticl... I do think CKM is a fake made up condition & the staging is a terrible idea Flozinate, glipinate - but shoving another disease and staging and guideline? Count me out!
See the #NephjC summary from @jamiekwillows.bsky.social www.nephjc.com/news/2026/06... cc @juancarlosqvelez.bsky.social @brycebarr.bsky.social
Heir to the Throne? Obinutuzumab in the membranous nephropathy MAJESTY trial — NephJC
This week, NephJC will discuss whether obinutuzumab is ready to outperform tacrolimus in primary membranous nephropathy
nephjc.com
Agree - it would likely be a N of 1000 + trial, and one would need funding of Ritux for control + Obi for intervention. Also, note when Tac was stopped per @brycebarr.bsky.social above! www.kireports.org/article/S246... from Ruggenenti et al in @kireports.bsky.social with same thoughts #ERA26
Critical Reappraisal of Obinutuzumab Randomized Trials in Membranous Nephropathy
We read with interest the commentary to our work by Giri et al, (1) and particularly their reference to the MAJESTY trial and its potential implications for the evolving therapeutic landscape of prima...
kireports.org
I did not get at all why this was tested when ritux is alteady effective. So why not test obi against ritux? I asked the investigator and he said it would not be feasible, and they made this to get fda approval which there apparently isn’t for ritux.
Bilirubin-stained hyaline cast containing renal tubular epithelial cells in a pt w/ESLD, AKI, T Bili 33, FENa 0.29%. Leucine crystal by bottom tip. This finding should not negate vasoconstrictor therapy 4 HRS coz it reflects subclinical tubular insult #UrinarySediment #UrineMicroscopy #Hepatorenal
Crisp broad RBC cast, surrounding pseudohyphae #UrinarySediment case of cryoglobulinemic glomerulonephritis, 2 months old specimen kept at room temp. #UrineMicroscopy #Glomerular
This post was prompted by the fact that I was recently approached by a drug sponsor conducting a randomized clinical trial with a new drug vs tacrolimus. I cannot in good faith offer that to a patient. No medical equipoise.
Juan Carlos Q Vélez, MD@juancarlosqvelez.bsky.social · 4mo agoWhen are clinical trials for membranous nephropathy going to stop using cyclosporin/tacrolimus as control group? We already know that CNIs are inferior to CYC, RTX & OBZ. It was already a criticizable choice in MENTOR. I cannot ethically offer that to a patient. Drug companies and FDA: please act
When are clinical trials for membranous nephropathy going to stop using cyclosporin/tacrolimus as control group? We already know that CNIs are inferior to CYC, RTX & OBZ. It was already a criticizable choice in MENTOR. I cannot ethically offer that to a patient. Drug companies and FDA: please act
“Mrs/Mr XYZ, we are going to request to have the plastic catheter in your neck removed since you are not going to require more dialysis 🙂”. Immediate reaction of happiness elicited, from the patient and/or family. One of the most fulfilling moments during Nephrology rounds.
1/5 There has been a major shift in how we treat IgA nephropathy. New studies have shown that kidney failure risk begins at lower levels of proteinuria than previously appreciated, and multiple trials have demonstrated that targeted therapies can reduce the risk of progression.
ASN Publications@asnpublications.bsky.social · 4mo agoWhy does your IgA nephropathy care depend on who you see? In a Manitoba study published in #ASNKidney360, doctors drove 31% of variability in biopsy timing and 7% in steroid use. kidney.pub/KID1232 Bryce Barr
Bilirubin-stained hyaline cast containing renal tubular epithelial cells in a pt w/ESLD, AKI, T Bili 33, FENa 0.29%. Leucine crystal by bottom tip. This finding should not negate vasoconstrictor therapy 4 HRS coz it reflects subclinical tubular insult #UrinarySediment #UrineMicroscopy #Hepatorenal
Helical RBC cast in a patient with atypical anti-GBM nephritis. #UrinarySediment #UrineMicroscopy
An interim analysis of a phase 3 trial involving patients with IgA nephropathy showed that 39 weeks of treatment with telitacicept led to a greater reduction in the 24-hour urinary protein-to-creatinine ratio than placebo. Full TELIGAN trial results and Research Summary: https://nej.md/4uFpMLz
