This study in #ASNKidney360 examined depletion of the antioxidant ergothioneine in patients undergoing dialysis. They compared levels in blood from patients on peritoneal dialysis hemodialysis, and healthy controls. Read more about what they found: kidney.pub/KID1105 @grahamabra.bsky.social

New out today: Antiproteinuric Effect of Sparsentan in Patients with Genetic-Associated FSGS Enrolled in the DUPLEX Trial Genetic FSGS CAN be treated. journals.lww.com/cjasn/abstra...

I’ll do a pitch for the ASN AKI-D guidance document here #nephjc @nephroninja.bsky.social pubmed.ncbi.nlm.nih.gov/40014384/

ASN Kidney Health Guidance on the Outpatient Management of Patients with Dialysis-Requiring Acute Kidney Injury - PubMed

This article contains a podcast at https://dts.podtrac.com/redirect.mp3/www.asn-online.org/media/podcast/JASN/2025_03_11_KTS_March2025.mp3

pubmed.ncbi.nlm.nih.gov

#NephJC the editorialist wondered if our control arm represented ‘unnecessary dialysis’ and was not ‘standard of care’—sounds like many at #NephJC do not feel the same way?

#NephJC The traditional approach is increase in native renal function and then dialysis cessation. We proposes a different paradigm: dialysis cessation to promote increase in native renal function.

#NephJC it is important to point out that ‘1st day of recovery’ was defined retrospective. On that day, GFR may be very low (so not ‘recovered’ in the way many people use the word). See 2 figures below for illustration. Both these patients contributed to those Kaplan-Meier curves separating early.

T2f Dialysis-Free Days by Day 28: Conservative: 21 days Conventional: 5 days Most pronounced divergence within the first 10-12 days Clinically, this means these patients spent most of their hospital course not needing dialysis, something no earlier AKI-D trial has demonstrated so clearly. #NephJC

T1c #NephJC 1️⃣Conservative RRT group RRT was done only if one of the following occurred: ✅BUN >112 mg/dL ✅Potassium >6.0 mmol/L, >5.5 after meds ✅pH <7.15 or HCO3 < 12 meq/L ✅Hypoxemia or pulmonary edema ✅Symptomatic overload ✅Clinician judgment 2️⃣ Conventional RRT was 3x/wk

T1a Population: stable AKI-D patients with realistic renal recovery potential Exactly the “gray zone” group we debate daily whether dialysis continuation is necessary. 👀Check out the inclusion/exclusion criteria #NephJC

Hi! I'm a nephrologist and clinical researcher at UCSF. COI: I was one of the LIBERATE-D investigators at the UCSF site. I made a BlueSky account today to join this discussion. #NephJC

Graham Abra Clinical nephrologist and educator COI Fan of the UCSF neph team! #NephJC

#NephJC This is Chi Hsu, senior author and one of the two PI’s for LIBERATE-D. Thanks for choosing our paper. I am borrowing UCSF Nephrology Division’s BlueSky account.

Excited about this @theisn.org initiative, especially under the leadership of @hswapnil.medsky.social as EIC. Nephrology needed this www.theisn.org/blog/2025/12...

Turning clinical experience into shared knowledge: ISN launches Kidney International Case ReportsTM - International Society of Nephrology

theisn.org

The Stanford African Scholars in #GlobalHealth (SASH) program is fostering innovation at a time of growing global health challenges. Through partnerships & knowledge exchange, physician-leaders from African countries gain skills & insights to improve care at home. https://stanford.io/4pt5IKq

It was really interesting researching this topic. Hope it’s useful.

UW Nephrology@uwnephrology.bsky.social · 8mo ago

Dr. Sarah Sanghavi (@sarahsanghavi.bsky.social) presents "Prolonging Circuit Life in CRRT" and discusses the consequences of CRRT interruptions as well as strategies to improve circuit life. #vascular #antigoagulation #kidney #nephrology #nephsky @uwmedicine.bsky.social youtu.be/JnOa6yQtPfQ

#NephSky as I ask every match day, what is the deal? Endocrinology and Rheumatology (what I would consider the closest comps to nephro) are following almost of their spots while we continue to...not. Do we simply have too many spots?

Bryan Carmody@jbcarmody.bsky.social · 8mo ago

It’s Fellowship Match Day!

Yup Figure 1.1 in incidence rate of ESRD in the US Seems to have slipped most people’s awareness 🤷🏽‍♂️

EPA and DHA has an effect on arrhythmias and SCD, especially formation of reentry arrhythmias. e.g. EPA and DHA modulates sodium, calcium and potassium ion channels affecting the cardiac action potential. #NephJC

Indeed! We did not know what to expect, but hopeful. Having worked on this for over a decade, I was initially "stunned" by the result but then not really surprised given the multitude of potential effects of EPA and DHA on the cardiovasculature, and our HD patients deficiencies in it #NephJC

Stop complaining about pill burden in ESRD! There is no pill you are giving your dialysis patient that has data half as impressive as this study. If they are taking too many pills have them stop any of the dozen pills they are taking with ZEERO data in ESRD. #NephJC

Actually, we actually found the opposite - many patients were wanting a "natural" treatment and didnt mind! Some actually left the study to buy commercial fish oil as they didnt know if they had placebo. But to be fair, some also left the study due to pill burden #NephJC

#NephJC

Up next 12/16/25 (our last #NephJC of the year) LIBERATE, A Conservative Dialysis Strategy and Kidney Function Recovery in Dialysis-Requiring Acute Kidney Injury. jamanetwork.com/jour...

We need a daily dose of 1600 mg EPA 800 mg DHA in an ethylester mix of fish oil Did I get that right @kidneyboy.bsky.social @pisces01.bsky.social ? The same company that made it for FISH and PISCES may come out with their formulation soon #NephJC

Since we don’t know the mechanism (secret sauce) hard to say. Is it the EPA/DHA quantities or the ratio or the “quality”, or something else that hasn’t been considered. This is also likely the basis of conflicting data #NephJC

a baby is making a funny face with the words this is confusing me written above it .

ALT: a baby is making a funny face with the words this is confusing me written above it .

media.tenor.com

Maybe not as easy as it sounds #NephJC

My first month of trying to prescribe fish oil at the dialysis unit has been a total failure Pharmacies arn’t filling scripts and patients can’t find OTC matches to dose prescribed in PISCES Anyone having success on the high seas?

Nephrology Journal Club@nephjc.bsky.social · 8mo ago

Holy Mackerel! 🐟 🦜Ahoy matey! Could fish oil unlock the mysteries of increased CV mortality in ESRD? 🏴‍☠️ #NephJC Join us for a lively trawling trip 12/2/25 🛥️at 9pm EST Check out the PISCES VA by @brianrifkin.bsky.social www.nephjc.com/news/piscesva

👇Here are the proposals for the #TopNephrology stories in 2025 🔥 Remember, you can only vote for your favorites if you have subscribed to #NephJC newsletter 📬 Soon we'll send you the voting link. Check your email. www.nephjc.com/news/2025/11...

Which were the Top Nephrology Stories of 2024? — NephJC

Time to vote for the Top Stories of 2025

nephjc.com

Maybe the most shocking study from #KidneyWk. 🐚From the depths of the oceans to #BlueSky, we're discussing PISCES 🐟 12/2/25 9pm EST. #NephJC Are you hooked🪝on fish oil for CV disease in ESRD, or are you throwing it back 🌊? www.nephjc.com/news/pisces-fishoil

Fish Oil in Dialysis: A Big Catch or an Empty Net — NephJC

Holy Mackerel! This week we will discuss fish oil use in maintenance hemodialysis patients. Could this be the one thing that bends the curve on CV mortality, or is it just a red herring?

nephjc.com

Holy Mackerel! 🐟 🦜Ahoy matey! Could fish oil unlock the mysteries of increased CV mortality in ESRD? 🏴‍☠️ #NephJC Join us for a lively trawling trip 12/2/25 🛥️at 9pm EST Check out the PISCES VA by @brianrifkin.bsky.social www.nephjc.com/news/piscesva

PISCES: The Visual Abstract — NephJC

Curious how n-3 PUFAs may cut serious cardiovascular events in dialysis? 🐟 A big signal, a big dose, and a big discussion ahead — don’t miss this #NephJC! Check out the VA made by our master Brian...

nephjc.com