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Gregor Bond

@gregorbond.bsky.social

transplant nephrologist and psychotherapy student in Vienna (Austria)

104 Posts641 Follower 587 Folgt

Gregor Bond @gregorbond.bsky.social · 2mo ago

Join us Friday 7:15 CEST for best of #ERA2026 @markusathome.bsky.social to learn more about TTV-guided immunosuppression in kidney transplantation #TTVguide youtu.be/OxbYH9yOd6w?...

62nd ERA Congress - Profs. Segelmark, Willcocks, Dixon, Fervenza, Bond, Lambers Heerspink, Neuen

YouTube video by MARKUS at HOMe

youtu.be

MedUni Wien @meduniwien.ac.at · 2mo ago

📢 #Bildung ist Zukunft. Darum braucht es starke Universitäten — und keine Kürzungen bei Wissenschaft und Forschung. Mit der Petition #unisretten wird ein klares Zeichen gegen den geplanten Sparkurs gesetzt. ✍️ Jetzt unterstützen! ⬇️

Jetzt unterzeichnen: #unisretten

Zur Petition!

mein.aufstehn.at

MedUni Wien @meduniwien.ac.at · 2mo ago

Successful trial ✅️ An international team coordinated by #MedUniVienna demonstrated in a #clinicaltrial that #TorqueTenovirus-guided dosing of #immunosuppressants in #kidneytransplant recipients is safe. More about the @ttvguidetx.bsky.social study coordinated by @gregorbond.bsky.social! ⬇️

Biomarker-guided immunosuppression following kidney transplantation successfully tested

Further details!

meduniwien.ac.at

Gregor Bond @gregorbond.bsky.social · 2mo ago

first data of the TTVguideIT RCT presented by @fredhaupenthal.bsky.social at ERA26 in Glasgow Torque Teno 🦠 virus guided immunosuppression 💊 is safe in kidney TX and might help reducing TAC dose #TTVguide

Gregor Bond @gregorbond.bsky.social · 2mo ago

First data of the TTVguideIT RCT presented @ERA26 in Glasgow 🏴󠁧󠁢󠁳󠁣󠁴󠁿 Personalized Immunosuppression 💊 by Torque Teno 🦠 virus in kidney TX is safe and might help reducing Tacrolimus #TTVguide @fredhaupenthal.bsky.social 👏

Gregor Bond @gregorbond.bsky.social · 3mo ago

the TTVguideTX team @research night for the public @meduniwien.ac.at Vienna - Austria all age groups were welcome to learn about science we presented the principle of TTV-guided immunosuppression #TTVguide

Gregor Bond @gregorbond.bsky.social · 4mo ago

Felix Herkner communicates the potential of TT virus 🦠 guided Immunosuppression to the Austrian 🇦🇹 public #TTVguide

Gregor Bond @gregorbond.bsky.social · 4mo ago

It would be great to see you Friday night this week @ researchers night @meduniwien.ac.at learn how the TT virus can be used as Immunometer kids are very welcome #TTVguide langenachtderforschung.at/station/6326

Viren können Superheroes sein oder wie kann man das Immunsystem messen? - #LNF26 Lange Nacht der Forschung

Wir erforschen wie man die Stärke des Immunsystems messen kann. Zuerst erklären wir Ihnen, anhand eines Posters und eines Animationsfilms wie das funktioniert und warum uns das TT Virus dabei hilft. D...

langenachtderforschung.at

Gregor Bond @gregorbond.bsky.social · 4mo ago

Torque Teno virus 🦠 predicts malignancy post kidney transplant #TTVguide

Gregor Bond @gregorbond.bsky.social · 6mo ago

clinical trial simulations to optimise analysis strategies for multiple endpoints highlight the trade-off between statistical efficiency and interpretability #ttvguide www.nature.com/articles/s41...

Comparison of primary analysis strategies of randomized controlled trials with multiple endpoints with application to kidney transplantation - Scientific Reports

Scientific Reports - Comparison of primary analysis strategies of randomized controlled trials with multiple endpoints with application to kidney transplantation

nature.com

Swapnil Hiremath 🍁🇨🇦@hswapnil.medsky.social · 7mo ago

Remember the TOPCAT story of what happened in Russia and Georgia? This is worse: www.science.org/content/blog... And in South Florida. From @dereklowe.bsky.social

It seems to be a recurring problem, though. As you can see from the link above, Science's team found that several of these clinical centers have previously fouled up trial data for other companies and other drugs, and that alone should make any responsible CRO avoid them like radioactive waste zones. But the problems are even deeper. It appears that many of these Miami-area centers are cheerfully enrolling "professional patients" who are signing up for as many trials as possible to collect the payments and benefits, and who are likely as not throwing the pills themselves away. By this point in the article, my head was in my hands, and I'm sure that's a common reaction. This sort of idiotic fraud is the exact opposite of medical research.

Swapnil Hiremath 🍁🇨🇦@hswapnil.medsky.social · 7mo ago

Should we be treating inpatient hypertension? Interesting case with two discussants (Michael Rothberg vs Tara Chang) www.nejm.org/doi/full/10.... I have to confess despite being a nihilist for treating inpatient BP I am tempted to do something in this setting.

A Man with Asymptomatic Hypertension
Sarah Gorey, M.B.
You are the intern on call for the night shift. You are paged to come to the surgical ward to assess a patient. A 63-year-old man with uncomplicated diverticulitis was admitted earlier in the day for antimicrobial and conservative treatment. He rarely visits his family doctor, is not aware of having high blood pressure, and does not take regular medications. You have been called because on a routine check of vital signs, the patient’s blood pressure was 185/115 mm Hg. All other vital signs were within normal limits. The patient has no symptoms; he has no headache, dyspnea, or chest or abdominal pain. He reports feeling slightly stressed at being admitted to the hospital today, which he was not anticipating, but had been sleeping comfortably before the nurse checked his vital signs.
On examination, he appears to be comfortable, and there is no clinical evidence of withdrawal from alcohol or other substances. His abdomen is soft and nontender, and on auscultation, no bruits are heard over the aorta or renal arteries. His pulses are 2+ and symmetric in all anatomical distributions. You note that his blood pressure was also high (166/97 mm Hg) at admission 4 hours earlier and had not been measured again until now. Routine laboratory test results from blood samples obtained at the time of admission show increased levels of leukocytes and inflammatory markers but normal kidney and liver profiles. The nurse manager confirms that the blood-pressure monitors on this ward have been calibrated recently. A repeat blood-pressure measurement obtained after the patient has rested quietly for 10 minutes is still elevated, at 182/103 mm Hg.
You must decide whether the patient’s blood pressure should be monitored over time on an outpatient basis (a “watchful waiting” approach) or whether he should begin receiving antihypertensive medications during this hospitalization.

Gregor Bond @gregorbond.bsky.social · 8mo ago

no screening in Austria 🇦🇹 😥

Joel Topf@kidneyboy.bsky.social · 8mo ago

OMG! A nationally televised commercial for urine albumin to creatinine ratio!

Gregor Bond @gregorbond.bsky.social · 9mo ago

Torque Teno Virus 🦠 ads to SOC to predict BK viraemia 🦠 can be 🦸‍♀️ #ttvguide www.sciencedirect.com/science/arti...

Predictive Value of TTV Viral Load for BKPyV DNAemia Depends on BKPyV-Specific Humoral Immunity in KTRs

Neutralizing antibodies (NAbs) have been proposed as biomarkers for stratifying BKPyV replication risk, while TTV viral load is recognized as a global…

sciencedirect.com

Gregor Bond @gregorbond.bsky.social · 9mo ago

thanks 🙏 BTS for the invitation! what a warm welcome to london 🇬🇧 I guess DSA, GEP, ddcfDNA and TTV will nicely come together as comprehensive immune monitoring post SOT bts.org.uk/bts-autumn-s... #TTVguide

BTS Autumn Symposium - British Transplantation Society

The Fundamentals of Transplantation: A Joint Educational Event by The Herrick Society of Trainees in Transplant Surgery & The British Transplant Physician Trainees

bts.org.uk

Gregor Bond @gregorbond.bsky.social · 9mo ago

Immune Monitoring Goes Viral 🦠 Torque Teno Virus for Immunologic Risk Stratification After Kidney Transplantation ⏩️ new review in TI 🔥 doi.org/10.3389/ti.2... #ttvguide

Gregor Bond @gregorbond.bsky.social · 9mo ago

the cure for kidney week FOMO 😀 www.nephjc.com/news/kidneyw...

Kidney Week in Houston: Day 1 — NephJC

in this edition: Atacicept in IgAN; Albuminuria as a surrogate outcome, Renal Remission and additional CONFIDENCE analysis

nephjc.com

Swapnil Hiremath 🍁🇨🇦@hswapnil.medsky.social · 9mo ago

The second sibeprenlimab paper in @nejm.org (At least we gave it an oral at #KidneyWk unlike the poster for the phase 2 data in 2023!) www.nejm.org/doi/full/10....

Sibeprenlimab in IgA Nephropathy — Interim Analysis of a Phase 3 Trial | NEJM

The cytokine A proliferation-inducing ligand (APRIL) is considered a key driver of the pathogenesis of IgA nephropathy. Sibeprenlimab, a humanized IgG2 monoclonal antibody, selectively binds to and...

nejm.org

Swapnil Hiremath 🍁🇨🇦@hswapnil.medsky.social · 9mo ago

And another ns-MRA Balcinrenone added to Dapa in proteinuric CKD #KidneyWK @thelancet.com www.thelancet.com/journals/lan...

Balcinrenone in combination with dapagliflozin compared with dapagliflozin alone in patients with chronic kidney disease and albuminuria: a randomised, active-controlled double-blind, phase 2b clinica...

In participants with chronic kidney disease at increased risk of disease progression, a fixed dose combination of balcinrenone and dapagliflozin was superior to dapagliflozin alone in reducing albumin...

thelancet.com

NEJM.org @nejm.org · 9mo ago

ORIGIN phase 3 trial: In an interim analysis of a clinical trial, atacicept, a fusion protein that binds and inhibits two cytokines thought to be central to the pathophysiology of IgA nephropathy, significantly reduced proteinuria. nej.md/3JEq8QL @asnkidney.bsky.social | #KidneyWk

American Society of Nephrology Kidney Week 2025
Original Article | Nov. 6, 2025 | NEJM.org
A Phase 3 Trial of Atacicept in Patients with IgA Nephropathy

Figure 2A. Change from Baseline in 24-Hr Urinary Protein-to-Creatinine Ratio through Week 36.

The NEJM identity sits at the bottom.

Swapnil Hiremath 🍁🇨🇦@hswapnil.medsky.social · 9mo ago

Eli Lilly continuing to hit it out the park Selective amylin agonist as an alternative to GLP1RAs? #eloralintide www.thelancet.com/journals/lan... in @thelancet.com (Yeah I know it’s #KidneyWk but what do we do till Houston wakes up!) cc @rnflex.bsky.social

Figure 2. Change in bodyweight
(A) Mean percent change in bodyweight from baseline to week 48, shown as observed means and bars indicating SEs. The model-based estimates of the mean percent change in bodyweight and differences among treatment groups at week 48 with the corresponding p values (efficacy estimand only) and 95% CIs are shown in (B) (efficacy estimand) and (D) (treatment-regimen estimand); bars indicate SEs. Multiplicity adjustment was not performed, and p values should be interpreted as exploratory. (C) shows the percentage of participants with bodyweight reductions of at least 5%, 10%, 15%, 20%, 25%, and 30% from baseline to week 48. The percentage of participants is annotated above each bar, calculated with the use of Rubin's rules by combining the percentages of participants who met the thresholds in imputed datasets. *The model-based estimates and 95% CIs from a mixed model repeated measures analysis for the efficacy estimand are shown on the right, denoted by 48.

Swapnil Hiremath 🍁🇨🇦@hswapnil.medsky.social · 9mo ago

Another simultaneous publication from the afternoon session Albuminuria as an acceptable surrogate outcome (per our discussion earlier today) www.nature.com/articles/s41... in @naturemedicine.bsky.social @nature.com sadly paywalled #KidneyWk

A meta-analysis of albuminuria as a surrogate endpoint for kidney failure - Nature Medicine

In a meta-analysis of 48 randomized trials of chronic kidney disease progression, reduction in the 6-month urinary albumin:creatinine ratio was associated with lower hazard ratios of established kidne...

nature.com

Swapnil Hiremath 🍁🇨🇦@hswapnil.medsky.social · 9mo ago

a conservative dialysis strategy in possibly recovering AKI helps people recover faster! jamanetwork.com/journals/jam... in @jama.com from #KidneyWk Like STARRT-AKi et al, at the other end? Small trial - needs replication or this is common sense?

A Conservative Dialysis Strategy and Kidney Function Recovery in Dialysis-Requiring Acute Kidney Injury

This trial examines whether a conservative dialysis strategy can improve recovery of kidney function for patients with acute kidney injury who require dialysis.

jamanetwork.com

Swapnil Hiremath 🍁🇨🇦@hswapnil.medsky.social · 9mo ago

low dose Tac + Everolimus is not superior to Tac + MMF in older transplant recipients in @asnpublications.bsky.social another LBCT from #KidneyWk published journals.lww.com/jasn/fulltex...

journals.lww.com

Gregor Bond @gregorbond.bsky.social · 9mo ago

jamesstein18.substack.com/p/my-hot-tak...

My Hot Take on PISCES, the New Fish Oil in Hemodialysis Study

I love when a new study challenges what we think we know.

jamesstein18.substack.com

Gregor Bond @gregorbond.bsky.social · 9mo ago

😲 too good to be true? nothing except tx reduces death on hd and now…. something safe, cheep and with more effect than tx (and more effect than in non hd) waiting for the @freelyfiltered.bsky.social podcast covering this paper www.nejm.org/doi/full/10....

Fish-Oil Supplementation and Cardiovascular Events in Patients Receiving Hemodialysis | NEJM

Cardiovascular disease is the leading cause of death in patients receiving hemodialysis, yet effective preventive therapies remain limited. Supplementation with n−3 polyunsaturated fatty acids, esp...

nejm.org

Swapnil Hiremath 🍁🇨🇦@hswapnil.medsky.social · 9mo ago

Natural history of RRT from the ERA registry The visual abstract in this case tells a lot academic.oup.com/ndt/advance-... @ndt-era.bsky.social #NephSky

Visual abstract
Sad story reflecting that most people start with HD and most of them die

Swapnil Hiremath 🍁🇨🇦@hswapnil.medsky.social · 10mo ago

Should we be screening every young child’s urine (as is done in some countries!) @rheaultm.bsky.social and Oliver Gross make the case in @kireports.bsky.social www.kireports.org/article/S246... Main issue: we have therapeutic options! #NephSky

Urine screening to early diagnose young individuals with CKD: a call for action

Alport syndrome is an inherited disorder of basement membranes leading to progressive chronic kidney disease, hearing loss, and ocular abnormalities in many affected patients. When the authors started...

kireports.org

Gregor Bond @gregorbond.bsky.social · 10mo ago

can viruses 🦠 be superheroes 🦸‍♂️ ? PhD student Felix Herkner just published the statistical analysis plan of the TTVguideIT trial 💪👏 Torque Teno virus guided immunosuppression #TTVguide data cleaning until Q1/26 analysis Q2/26 trialsjournal.biomedcentral.com/articles/10....

Statistical analysis plan for TTVguideIT—a multicentre, patient- and assessor-blinded, non-inferiority, randomised and controlled phase II trial to compare standard and Torque Teno virus-guided immuno...

Background Non-interventional studies indicate an association between Torque Teno Virus (TTV) load in peripheral blood and immunosuppression related outcomes in kidney transplant recipients. This make...

trialsjournal.biomedcentral.com