Haaris Ahsan Safdari
@haarissafdari.bsky.social
Staff Scientist EM @ MRC LMB, Cambridge 🇬🇧 Single particle cryo-EM, cryo-electron tomography
ICYMI: New online! A new antibiotic scaffold hits a new target
A new antibiotic scaffold hits a new target
Nature Reviews Microbiology, Published online: 19 June 2026; doi:10.1038/s41579-026-01336-5This study describes the discovery of a new antibiotic with a previously unknown mode of action.
dlvr.it
the 2nd paper in Nature *this month* by Gerard D. Wright! that's the 1st one www.nature.com/articles/s41...
A natural depsipeptide antibiotic binds the E-site of the bacterial ribosome - Nature
Improved fractionation strategies can identify antibiotics with previously unseen scaffolds and mechanisms, exemplified by manikomycin from Streptomyces rimosus, which acts by targeting the E-site of ...
nature.com
A 'megacluster' of genes found in a common soil bacterium can produce a range of antibiotics that can act against multi-drug-resistant bacteria go.nature.com/4xObGKf
Antibiotic cocktail made by soil bacteria can kill superbugs
Four antibiotic compounds produced in Streptomyces bacteria attack multiple parts of an essential metabolic pathway.
go.nature.com
Yes ! www.nature.com/articles/s41...
A natural depsipeptide antibiotic binds the E-site of the bacterial ribosome - Nature
Improved fractionation strategies can identify antibiotics with previously unseen scaffolds and mechanisms, exemplified by manikomycin from Streptomyces rimosus, which acts by targeting the E-site of ...
nature.com
Manikomycin, which blocks the exit site of the protein-producing machinery in bacteria, is the fourth major discovery from antimicrobial resistance expert Gerry Wright’s research team in recent months. news.mcmaster.ca/mcmaster-res... #CdnPSE (2/2)
McMaster researcher’s latest antibiotic discovery offers new way to kill drug-resistant bacteria
Researchers at McMaster University have discovered a new antibiotic that kills some of the world’s most dangerous and drug-resistant bacteria — and does so by targeting a previously unknown…
news.mcmaster.ca
“the compound—known as manikomycin—is the first antibacterial agent known to target the E-site in the large ribosomal subunit, opening the door to an entirely new class of treatments.” www.genengnews.com/topics/infec...
New Antibiotic, Manikomycin, Acts on Novel Ribosomal Target
Researchers discover manikomycin, a novel antibiotic that kills drug-resistant bacteria by targeting a previously unknown ribosomal target.
genengnews.com
New Antibiotic Found in Dirt Targets Superbugs in a Way ‘Never Been Seen Before’: A collaborative team of U.S., Canadian, and German researchers has discovered manikomycin, a novel peptide antibiotic derived from the soil bacterium *Streptomyces rimosus*, the same sou… https://ranked.news/976616?u=b
🧫 Antibiotikum gegen multiresistente Keime entdeckt: Ein Forschungsteam unter UHH-Beteiligung hat in einem bereits untersuchten Bodenbakterium den neuen Wirkstoff Manikomycin gefunden. Die Entdeckung zeigt: Bekannte Mikroorganismen besitzen weiterhin Potenzial für die Entwicklung neuer Antibiotika.
Neues Antibiotikum gegen multiresistente Keime entdeckt
uni-hamburg.de
New class of antibiotics? Please. "The compound, called manikomycin, was identified by a team led by McMaster..Early testing showed it was effective against several priority pathogens, including salmonella, E. coli & klebsiella. “What makes this exciting is that it’s a brand new unique structure”
Unofficial CTV News Mirror@ctvnews-mirror.bsky.social · 2mo agoCanadian-led researchers discover antibiotic that targets drug-resistant bacteria
Canadian-led team of scientists discover new antibiotic hidden in decades-old bacterium https://www.ctvnews.ca/sci-tech/article/canadian-led-researchers-discover-antibiotic-that-targets-drug-resistant-bacteria/ ↷ canadahealthwatch.ca/featured 🍁
Manikomycin A is not going to be a drug, but it *is* a very promising starting point for new antibiotic development www.science.org/content/blog...
A New Antibiotic Idea From An Old Source
science.org
Biochemiker und Pharmazeuten aus den USA, Kanada und Deutschland haben gemeinsam ein neues, natürlich vorkommendes #Antibiotikum entdeckt: #Manikomycin. https://gizmodo.com/new-antibiotic-found-in-dirt-targets-bacteria-in-a-way-never-been-seen-before-2000770712
New Antibiotic Found in Dirt Targets Superbugs in a Way ‘Never Been Seen Before'
Researchers tested their newly discovered peptide against one common antibiotic-resistant bacteria. Only about one in every hundred million survived to pass on genetic resistance.
gizmodo.com
Ribosome hibernation in archea with HibA, with a bacterial line hpf/raiA domain rdcu.be/foDtr
A family of ribosome hibernation factors widespread in Archaea
Nature Communications - Ribosome hibernation preserves translation machinery during stress. Here, the authors identify a ribosome hibernation factor that is widespread in archaea and combines...
rdcu.be
A natural depsipeptide antibiotic binds the E-site of the bacterial ribosome Very important! A new antibiotic working in a very different way. www.nature.com/artic... 1/5
A natural depsipeptide antibiotic binds the E-site of the bacterial ribosome
Nature - Improved fractionation strategies can identify antibiotics with previously unseen scaffolds and mechanisms, exemplified by manikomycin from Streptomyces rimosus, which acts by targeting...
nature.com
Flipping antimicrobial peptides in the exit tunnel of the bacterial ribosome | Nature Communications https://www.nature.com/articles/s41467-026-74007-x
Flipping antimicrobial peptides in the exit tunnel of the bacterial ribosome - Nature Communications
In this work authors show how minimal mutations in proline-rich antimicrobial peptides can flip their orientation in the ribosome exit tunnel, switching their mechanism from stalling translation termination to halting initiation - revealing a possible host strategy against evolving pathogens.
nature.com
A narrow ribosome tunnel can act as a checkpoint for bacterial protein production. Some peptides block it directly, while another can trigger a temporary pause under specific stress. doi.org/hb62q9
Ribosome tunnel interactions reveal how bacteria can pause protein production
How do bacteria regulate the production of their proteins? Researchers at the University of Hamburg, in collaboration with international partners, have now demonstrated how small protein building blocks, known as peptides, specifically influence bacterial protein production.
phys.org
🚨 Nature Reviews Microbiology highlights our Nature paper on Manikomycin. A new antibiotic scaffold targeting the ribosomal E-site → new mechanism against drug-resistant bacteria. www.nature.com/articles/s41...
A new antibiotic scaffold hits a new target - Nature Reviews Microbiology
This study describes the discovery of a new antibiotic with a previously unknown mode of action.
nature.com
🚨 Nature Reviews Microbiology highlights our Nature paper on Manikomycin. A new antibiotic scaffold targeting the ribosomal E-site → new mechanism against drug-resistant bacteria. www.nature.com/articles/s41...
A new antibiotic scaffold hits a new target - Nature Reviews Microbiology
This study describes the discovery of a new antibiotic with a previously unknown mode of action.
nature.com
#NatMicroPicks Hidden in plain sight! 💊🦠 Assessing overlooked minor compounds uncovered a new antibiotic, manikomycin, from well-studied Streptomyces species that kills bacteria by uniquely targeting the ribosomal E-site #MicroSky www.nature.com/articles/s41...
A natural depsipeptide antibiotic binds the E-site of the bacterial ribosome - Nature
Improved fractionation strategies can identify antibiotics with previously unseen scaffolds and mechanisms, exemplified by manikomycin from Streptomyces rimosus, which acts by targeting the E-site of ...
nature.com
Das hört sich nach einer sehr guten Nachricht an. #Antibiotika „Manikomycin is the first antibacterial agent, to our knowledge, to target the critical but underexplored E-site in the large ribosomal subunit, highlighting its value as a lead for developing new antibiotics.“
Celery Caraway@celerycaraway.bsky.social · 2mo ago🚨 Our Nature paper on Manikomycin is a Research Highlight in Nature Reviews Drug Discovery. A new antibiotic. A new ribosomal target (E-site). Activity against MDR pathogens. doi.org/10.1038/d415...
New antibiotic targets novel ribosomal site
Discover the world’s best science and medicine | Nature.com
doi.org
