The Rockefeller University @rockefeller.edu · 2w agoRockefeller's C. David Allis revolutionized our understanding of how genes are expressed. His discoveries ushered in the modern era of chromatin biology and epigenetics and laid the foundation for new approaches to treating cancer and other diseases. #125YearsofRockefeller
The Future Leaders in Biomedical Sciences Scholarships are open to candidates of Black or mixed Black heritage: www.crick.ac.uk/careers-and-...
Future Leaders in Biomedical Sciences Scholarships
Open to candidates of Black or mixed Black heritage only.
crick.ac.uk
Applications are open for our new AI/ML clinical fellowships, combining formal MSc-level training in AI and machine learning with PhD or postdoctoral research at the Crick. Find out more about the programme and apply by 11 November: https://bit.ly/4hxmAgn
AI/ML clinical fellows
Our clinical training pathway integrating AI and machine learning with discovery research.
crick.ac.uk
Our Chief AI Scientist, Mihaela van der Schaar, contributed to a @cellpress.bsky.social feature on AI in biomedical research, joining seven other researchers to discuss the opportunities and challenges ahead. Real the full article: www.cell.com/cell/fulltex...
Wherever we look, insect numbers are declining... but most insect life on Earth is found in locations we aren't actively monitoring. @justinmcrocker.bsky.social discusses the #insect decline and how can we build the planetary observatory that #biodiversity requires @plosbiology.org 🧪 plos.io/4qzS2yv
Join us for our first online AI for Biological Discovery Seminar, where our Chief AI Scientist Mihaela van der Schaar will host Caroline Uhler to discuss her research at the intersection of machine learning, statistics and genomics. Learn more and book your free ticket: https://bit.ly/4xAvNLL
AI in Biology Seminar | Professor Caroline Uhler
A new AI for Biological Discovery Seminar Series, presented by the Francis Crick Institute.
bit.ly
Our preprint is now out in @natgenet.nature.com ! doi.org/10.1038/s415... We measured Sox2 promoter bursting dynamics with the SCR enhancer positioned at different distances within a genomic locus devoid of confounding effects in mESC: Main findings in the 🧵 below:
Enhancer control of promoter activity and variability via frequency modulation of clustered transcriptional bursts - Nature Genetics
Tünnermann et al. use live-cell imaging to study promoter activity under the control of an enhancer inserted at different genomic distances. RNA production from the promoter occurs in clusters of tran...
doi.org
Luca Giorgetti lab @FMI@lucagiorgetti.bsky.social · 2y agoCelebrating 10 years of our lab with a new preprint: www.biorxiv.org/content/10.1... How does enhancer location within a TAD control transcriptional bursts from a cognate promoter? Experiments by Jana Tünnermann and modelling by Gregory Roth
🧬NEW PAPER🧬 To what extent is cancer development deterministic? Does the germline genome affect that predictability? Find out in our #StrainDifferences paper @nature.com "Genetic background sets the trajectory of experimental cancer evolution" www.nature.com/articles/s41... 🧵[1/14]
Genetic background sets the trajectory of experimental cancer evolution - Nature
Experimentally replaying tumour evolution in divergent mouse strains reveals the importance of interactions between genetic ancestry and acquired cancer-driving mutations in shaping the earliest stage...
nature.com
Our ambition to combine artificial intelligence with fundamental biology and medicine continues to evolve as we welcome Mihaela van der Schaar as our Chief AI Scientist. Read more: www.crick.ac.uk/news/2026-06...
Mihaela van der Schaar appointed Crick Chief AI Scientist
The Francis Crick Institute has appointed Professor Mihaela van der Schaar as its Chief AI Scientist, advancing its ambition to combine artificial intelligence with fundamental biology and medicine, c...
crick.ac.uk
The first European conference on sex differences featured research looking at the source of physical differences in males and females. A participant reflected on conference takeaways, including the impact on personalised healthcare. www.embl.org/news/science...
Five takeaways from the first European conference on sex differences | EMBL
At a recent EMBL conference, scientists shared research aimed at understanding the source of gender differences.
embl.org
New paper out in @cp-cellstemcell.bsky.social. We uncover unexpected complexity in how metabolism changes when the embryo implants or when stem cells exit naive pluripotency, revealing a central role for dynamic TCA cycle rewiring in cell fate decisions. www.cell.com/cell-stem-ce...
TCA cycle rewiring underpins histone acetylation sourcing and cell-fate transitions during exit from naive pluripotency
Using carbon tracing and functional experiments, Kafkia, Pladevall-Morera, et al. show that TCA cycle rewiring underlies mouse embryo implantation and the exit from naive pluripotency. In this context...
cell.com
Congratulations to Vikas Trivedi & collaborators for being awarded the HFSP grant! An international team coordinated by EMBL Barcelona researchers has been awarded $1.5M to study how developing organisms stay on track despite climate-driven temperature instability. www.embl.org/news/awards-...
New funding to explore how embryos survive temperature stress in the era of climate change | EMBL
An international team coordinated by Vikas Trivedi at EMBL Barcelona has been awarded an HFSP grant worth $1.5 million (€1.3 M) to study how developing organisms stay on track despite climate-driven t...
embl.org
“We’re hoping doors will open for researchers to ask questions about how connections are made in the brain in mice and maybe, one day, humans.” - @andreas-t-schaefer.bsky.social Read about the new NIH-funded program to map brain circuitry using X-rays: www.crick.ac.uk/news/2026-03...
Can X-rays reveal how the brain is wired?
Neuroscientist Andreas Schaefer is spearheading a new project to capture the intricacies of the mouse brain using X-rays, bringing researchers closer to a complete map of its neural connections.
crick.ac.uk
“I think it’s a real mistake to forget where the pipeline for all this begins.” John Diffley reflects on the importance of basic research, his mission to decode DNA replication and recreate it in the lab, and the scientific optimism of the 1960s that helped shape it. www.crick.ac.uk/news/2026-03...
Crick evolutionary biologist @margaridamcm.bsky.social is working with conservation charity ZSL to investigate an enduring mystery: how the placenta has evolved with incredible variation across species. Read the full story: www.crick.ac.uk/news/2026-03...
Two Crick group leaders are joining Cancer Grand Challenges teams to tackle big questions in cancer research. Leanne Li leads a team studying how tumours interact with the nervous system, and Vivian Li joins a @ucl.ac.uk-led team working to rewire cancer cells. 🔗 www.crick.ac.uk/news/2026-03...
We’re excited to be working with @britsciassoc.bsky.social to co-lead EDIS, a coalition working to improve equality, diversity and inclusion in science and health research. Find out more about the plans for EDIS's next chapter ⤵️ www.crick.ac.uk/news/2026-03...
The Crick to co-lead the Equality, Diversity and Inclusion in Science and Health (EDIS) group
The Crick will co-lead the Equality, Diversity and Inclusion in Science and Health (EDIS) group with hosts, the British Science Association, supported by a £10 million grant over seven years from Well...
crick.ac.uk
EMBL is deeply saddened by the passing of our Interim Director General Peer Bork, a pioneering scientist who left an indelible imprint on life science research in Europe and beyond. We extend our deepest condolences to his family, friends, and colleagues. www.embl.org/news/people-...
Don't forget to submit your abstract for #EESSexDifferences by 19 January: s.embl.org/ees26-07-bl This new symposium will explore how sex influences health and disease through genetic, hormonal, immune, metabolic, and environmental factors 🧬 🗓️ 27 – 30 Apr 📍 EMBL Heidelberg and Virtual
💡 New paper out in @natcellbio.nature.com 💥💥💥🚀🚀🚀 We uncover an unexpected role for endogenous Xist RNA in regulating X-linked genes that escape X-inactivation well beyond early development, in differentiated, non-dividing cells and in vivo post implantation embryos 👇👇👇👇
Agnese Loda@agneseloda.bsky.social · 10mo agoVery happy to share our paper rdcu.be/eUImj out today in @natcellbio.nature.com 🎉🎉🎉 We uncover an unexpected role for endogenous Xist RNA in regulating X-linked genes that escape X-inactivation.
Crick group leaders work across disciplines, supported by core funding and mentoring to build ambitious, curiosity-driven research. Apply now to join us ➡️ www.crick.ac.uk/careers-stud...
We're now recruiting early career group leaders at the Crick to lead ambitious research programmes and explore bold scientific questions. Hear our Director, Edith Heard, explain why the Crick is a unique place for curiosity-driven research. Apply now ➡️ www.crick.ac.uk/careers-stud...