Designing a “cell village”-based fitness screening approach and developing Townlet, @mfwells.bsky.social, @hjp.bsky.social, & co of @ajhgnews.bsky.social's latest article identify rare variant-associated overgrowth & genetic modifiers of NPC proliferation & lead sensitivity: https://bit.ly/4xsj4dm

The ISG Atlas: a loss-of-function analysis characterizes antiviral properties of interferon stimulated genes www.nature.com/articles/s41... @natcomms.nature.com

Thrilled to see this out. What started out as a chat several years back with @drfejzo.bsky.social about leveraging publicly available data on hyperemesis gravidarum GWAS turned into a wonderful collaboration with April Shu, @mvaudel.bsky.social, @xwww.bsky.social and many others! rdcu.be/fdl9k

Multi-ancestry genome-wide association study of severe pregnancy nausea and vomiting

Nature Genetics - Multi-ancestry GWAS meta-analysis identifies risk loci for severe nausea and vomiting of pregnancy. Downstream analyses explore maternal and fetal contributions of these loci and...

rdcu.be

Happy to share our latest work out now in Immunity @cp-immunity.bsky.social. doi.org/10.1016/j.im.... We provide insight into how influenza infections detrimentally impact cardiovascular health. Building on clinical observations, we show that influenza damages the heart and lowers its function.

Influenza hijacks myeloid cells to inflict type-I interferon-fueled damage in the heart: Immunity www.cell.com/immunity/ful...

Influenza hijacks myeloid cells to inflict type-I interferon-fueled damage in the heart

Respiratory infection and cardiovascular disease risk are tightly intertwined clinically, but the mechanisms of this relationship are largely unknown. Here, Downey et al. reveal how influenza traffics...

cell.com

Influenza hijacks myeloid cells to inflict type-I interferon-fueled damage in the heart @cp-immunity.bsky.social www.cell.com/immunity/ful... @jeffdowney11.bsky.social @filswirski.bsky.social

Exciting updates!! (1) I just opened my lab at Boston Children’s Hospital (Harvard-affiliated) (2) I’m hiring a postdoc focused on integrating GWAS and functional genomic data. Reach out if you’re interested or connect at ASHG next week! (3) Learn more at stroberlab.com

Strober Lab

The Strober lab is a computational group at Boston Children's Hospital (a Harvard Medical School affiliated hospital) focused on developing statistical and machine learning tools applied to human gene...

stroberlab.com

I'm hiring a computational biologist interested in complex trait genetics using deep learning approaches. Reach out to me, if interested.

yet, I constantly find myself having to explain this in most spaces where important conversations and decisions (regulatory, policy, higher education, etc) take place

Daniel José Older@djolder.bsky.social · last yr.

If I have to explain to you why it's a bad idea to use a machine that makes shit up 15-80% of the time AND destroys the environment AND contributes to rising fascism and genocide AND puts brilliant skillful creatives out of work by stealing their work, then we're already speaking different languages

It is depressing, but all too predictable, how swiftly we’ve gone from the Social Science Genetic Association Consortium offering reassurances about the uses of behavioural polygenic scores to one of their lead authors marketing embryo selection for IQ

Staff scientist position (computational): I am looking for a computational scientist to join my genomics lab at Stanford. They should have an outstanding skillset in ML/statistical methods for genomic applications, postdoc experience and a strong publication record. #sciencejobs

ICE just arrested Brad Lander, the NYC Comptroller and one of the leading candidates for Mayor, without grounds. He was conducting routine immigration court work, escorting individuals from hearings. He asked ICE for their warrant - well within his legal rights. This is political intimidation.

Aaron Reichlin-Melnick@reichlinmelnick.bsky.social · last yr.

Whoa! NYC mayoral candidate and current city Comptroller Brad Lander seemingly arrested at the NYC immigration court while attending to escort someone attending their hearing.

what the actual fuck

If we want to connect genetic variation to disease, we need to move beyond baseline conditions. Our study shows that dynamic, context-specific regulation holds the key to understanding many unexplained GWAS signals. The preprint again: www.biorxiv.org/content/10.1...

Disease-associated loci share properties with response eQTLs under common environmental exposures

Many of the genetic loci associated with disease are expected to have context-dependent regulatory effects that are underrepresented in the transcriptomes of healthy, steady-state adult tissues. To un...

biorxiv.org

Delighted to share that one of my major PhD projects has been published today in Current Biology. In this paper, we look into the genetic population structure and demographic histories of two populations in Sri Lanka: the Sinhalese and Adivasi [1/n]. www.cell.com/current-biol...

Population histories of the Indigenous Adivasi and Sinhalese from Sri Lanka using whole genomes

Sri Lanka is home to diverse ethnic groups with different genetic histories. Urban Aragon et al. find that despite close genetic affinities, Indigenous Adivasi have more hunter-gatherer ancestry and l...

cell.com

Now published in PNAS: www.pnas.org/doi/10.1073/...

Molly Przeworski@mollyprz.bsky.social · 2y ago

“The distribution of highly deleterious variants across human ancestry groups”. Preprint with Anastasia Stolyarova and @gcbias.bsky.social: www.biorxiv.org/content/10.1...

I didn't have much hope that we'd find genetic determinants of long-COVID, but after years of work, Vilma Aho, Tomoko Nakanisha, Hugo Zeberg and Hanna Ollila made it happen! (Among a few others :-)) www.nature.com/articles/s41...

Genome-wide association study of long COVID - Nature Genetics

A genome-wide study by the Long COVID Host Genetics Initiative identifies an association between the FOXP4 locus and long COVID, implicating altered lung function in its pathophysiology.

nature.com

“Should AI be allowed to review papers or grant proposals” always reveals a thing I think people don’t understand about algorithmic bias 🧵

PIs who think their research isn’t political: yes it is, it always is

📣Online now from Fu et al! 📄Role of X chromosome and dosage-compensation mechanisms in complex trait genetics

Role of X chromosome and dosage-compensation mechanisms in complex trait genetics

We show that the X chromosome, understudied in genome-wide association studies, contributes to complex traits in a manner shaped by dosage-compensation mechanisms. We find near-full X inactivation bal...

cell.com

www.biorxiv.org/content/10.1...

Disease-associated loci share properties with response eQTLs under common environmental exposures

Many of the genetic loci associated with disease are expected to have context-dependent regulatory effects that are underrepresented in the transcriptomes of healthy, steady-state adult tissues. To un...

biorxiv.org

Scientists must push back against the threat of rising white nationalism and the dangerous and pseudoscientific ideas of eugenics https://go.nature.com/4jGqiUc

Eugenics is on the rise again: human geneticists must take a stand

Scientists must push back against the threat of rising white nationalism and the dangerous and pseudoscientific ideas of eugenics.

go.nature.com

They are coming for every university, if you think you’re safe because it hasn’t been yours yet I don’t know what to tell you. Join AAUP, refuse to comply, organize your colleagues

Trump administration freezes $175 million in federal funding to Penn

According to a White House tweet, Wednesday's decision is a result of Penn's

thedp.com

Biomedical value of studying human diversity spotlighted by 5-nation asian Immune Diversity Atlas (AIDA) of circulating immune cells from healthy donors www.cell.com/cell/fulltex... @cellcellpress.bsky.social @jayshin.bsky.social

The @nytimes.com just discovered parallel computing.

How do you study gene-environment (GxE) interactions in humans? Well, there's probably no way to avoid studying each exposure individually, but what about the cellular context? If you choose directed differentiation, you have to study GxE one cell type at a time. If you choose an organoid system -

for Sasha & his family www.gofundme.com/f/rememberin...

Donate to Remembering Sasha Kirsanov: In Our Hearts Always, organized by Michelle Dumler-McKeever

In memory of Alexandr “Sasha” Kirsanov. We will keep you in o… Michelle Dumler-McKeever needs your support for Remembering Sasha Kirsanov: In Our Hearts Always

gofundme.com

absolutely devastating — i feel incredibly grateful to have had you as a coach and you will be missed dearly, Sasha 🤍

CoastTV@coasttv.bsky.social · 2y ago

In a letter from University of Delaware President, Dennis Assanis, a former UD Figure Skating Club coach, Alexandr ‘Sasha’ Kirsanov was among those who died in the plane crash over Washington D.C. Wednesday night.

Here’s what’s what at UChicago. Not good.

The sword has now been brandished over civil society, including scientists, universities, and other NGOs. Who, including university presidents, will have any backbone in defending their jnstitutions’ missions? Or will they take on the Zuckerberg/ Bezos pose? www.nytimes.com/live/2025/01...

Trump Administration Live Updates: White House Orders Federal Grants Pause (Gift Article)

nytimes.com