A conserved motif tunes Sidekick condensate dynamics to control tricellular junction recruitment during epithelial remodeling

A conserved motif tunes Sidekick condensate dynamics to control tricellular junction recruitment during epithelial remodeling

Spatial regulation of cell adhesion molecules in tissue dynamics underpins morphogenesis. Uechi et al. found that condensate dynamics of Sidekick, tuned by its conserved motif, contributes to its confined accumulation to tricellular junctions and molecular recruitment during epithelial dynamics, which eventually helps epithelial remodeling.

dlvr.it

Spatial regulation of adhesion molecules is crucial for multicellular systems. Tricellular junctions (TCJs) represent the example. We found that gel-like condensation of a TCJ protein stabilizes its accumulation even in tissue dynamics, which ensures molecular recruitment and epithelial remodeling.

A conserved motif tunes Sidekick condensate dynamics to control tricellular junction recruitment during epithelial remodeling

Spatial regulation of cell adhesion molecules in tissue dynamics underpins morphogenesis. Uechi et al. found that condensate dynamics of Sidekick, tuned by its conserved motif, contributes to its conf...

cell.com

EMBL scientists found metabolism controls embryonic development tempo through signalling in a way separate from its established metabolic function. More research related to this signalling could illuminate how it guides cell fate, developmental timing -- even disease. www.embl.org/news/science...

When metabolism provides more than fuel | EMBL

A new study observed the key signalling role that metabolism plays in controlling the tempo of development.

embl.org

Patrick's paper is finally out, a label-free method to measure the composition of multicomponent biomolecular condensates!

A label-free method for measuring the composition of multicomponent biomolecular condensates - Nature Chemistry

Biomolecular condensates are made of multiple components but current techniques cannot capture their complex composition quantitatively. Now it has been shown that the dense-phase binodal point defini...

nature.com

Physics of Life Dresden@poldresden.bsky.social · 12mo ago

New findings out today in Nature Chemistry from the Brugués @brugueslab.bsky.social at PoL, alongside colleagues at @mpi-cbg.de and the IPF Dresden 🧪 The authors have discovered a new method to identify the molecular makeup of biomolecular condensates Read our press release here: tud.link/ajwtaz

Out today in @nature.com: Together with the Honigmann, Shevchenko, Drobot and Hof labs, we present a general workflow for imaging the localization and transport of individual lipids in cells and mapping their metabolism. www.nature.com/articles/s41...

Excited to share our latest work out in @pnas.org! We show that the #SARSCoV2 nucleocapsid protein directly prevents DNA recognition of the immune sensor #cGAS by competing for DNA, which may delay early innate immune responses during infection. www.pnas.org/doi/epub/10.... #innateimmunity

We are very happy that XiaoYan's (Andy!) paper is out, congratulations to all authors @cellpress.bsky.social @xiaoyan52802927.bsky.social www.cell.com/cell/fulltex... Demixing of TDP-43 inside stress granules generates pathological aggregates linked to ALS/FTD @mpi-cbg.de @biotec-tud.bsky.social

The tricellular junction is a unique place where three or more cells contact. Here is our latest preprint showing the role of protein condensation in organizing molecular localization and function at tricellular junctions. www.biorxiv.org/content/10.1...

Condensation of Sidekick at tricellular junctions organizes mechanical forces for cell-cell adhesion remodeling

Epithelial morphogenesis relies on coordinated multicellular movements regulated by adhesion and force-generating molecules. It remains elusive how cells ensure organization of these molecules in spac...

biorxiv.org

Some small molecules modulate protein condensation in cells, but how? Our latest work shows a possible mechanism of action of the small molecule lipoamide. This molecule prevents condensation of stress granules whose components are found as protein aggregates in ALS. www.nature.com/articles/s41...

Small-molecule dissolution of stress granules by redox modulation benefits ALS models - Nature Chemical Biology

Uechi et al. found that a small-molecule lipoamide dissolves stress granules (SGs) by targeting SFPQ, a redox-sensitive disordered SG protein, alleviating pathological phenotypes caused by amyotrophic...

nature.com