Alexandre Hofer
@hofalex.bsky.social
R&D bioorganic chemist in biotech. High affinity to nucleotides and nucleic acids. All views my own.
📣📣 Come and work with us! 📣📣 Interested in synthesising new molecules for Illumina's sequencing technologies of the future? Join our R&D team in Cambridge (UK)! #UKChemJobs #ChemJobs illumina.wd1.myworkdayjobs.com/en-US/illumi...
Scientist (Synthetic Chemistry)
What if the work you did every day could impact the lives of people you know? Or all of humanity? At Illumina, we are expanding access to genomic technology to realize health equity for billions of pe...
illumina.wd1.myworkdayjobs.com
📣📣 Come and work with us! 📣📣 Interested in synthesising new molecules for Illumina's sequencing technologies of the future? Join our R&D team in Cambridge (UK)! #UKChemJobs #ChemJobs illumina.wd1.myworkdayjobs.com/en-US/illumi...
Scientist (Synthetic Chemistry)
What if the work you did every day could impact the lives of people you know? Or all of humanity? At Illumina, we are expanding access to genomic technology to realize health equity for billions of pe...
illumina.wd1.myworkdayjobs.com
Light-activated metal complexes have been shown to disable antibiotic resistance enzymes in E. coli, significantly enhancing the effectiveness of existing antibiotics without harming human cells. doi.org/hbcxrb
How phototherapy could reverse antibiotic resistance
Lars Stevens-Cullinane works in a dark room. But he's not processing negatives and printing photographs on light-sensitive paper; he's testing whether brief flashes of light can make drug-resistant bacteria sensitive to antibiotics.
phys.org
Even I’m not sure this will end well. Graphics courtesy of Dylan Patel of SemiAnalysis.
📆 Deadline: 14 November. 🩺 Doctoral Clinical Fellows programme (3-year PhD) 🤝 Exciting collaboration with the amazing @jeanninehess.bsky.social Curating bioactive chemical space in pathogenic bacteria using accumulation signatures across species ✍️ Apply here: www.crick.ac.uk/careers-stud...
Johnson lab and Hess lab | Curating bioactive chemical space in pathogenic bacteria using accumulation signatures across species
crick.ac.uk
🧪 Excited to share our new work on reactive metallo-scaffolds (r-mS)! We combine metal complexes with chemoproteomics to discover new liganding sites across the proteome! Shout out to a great collaboration with GSK! Fantastic team effort 🫶🏻 chemrxiv.org/engage/chemr...
Proteome-Wide Target Identification Using Reactive Metallo-Scaffolds (r-mS): A Platform for Metallodrug Discovery
Metal complexes offer unique opportunities as scaffolds in chemical biology and drug discovery, with tuneable geometry, modular coordination environments, and structural features not readily accessibl...
chemrxiv.org
📣Preprint 📣 You want to degrade a protein in Gram-negatives? We have tackled this challenge! Detailed study of our Light-Activated Metal-Dependent Protein Degradation LAMP-D system in targeting and rescuing NDM-1 activity. What an amazing team effort 🫶🏻 doi.org/10.26434/che...
Light-Activated Metal-dependent Protein Degradation (LAMP-D): A Heterobifunctional Ruthenium(II) Photosensitizer Targeting New Delhi Metallo-β-lactamase 1
The growth of antimicrobial resistance (AMR) is a significant global health threat, yet despite this alarming trend, antibiotic drug discovery has significantly slowed. Most compounds entering the cli...
doi.org
Imagine a small molecule that degrades a target protein like PROTACs, but does so independently of any of the host cell's degradation machinery, so you can go and do targeted protein degradation in gram-negative bacteria: doi.org/10.26434/che...
Jeannine Hess@jeanninehess.bsky.social · last yr.🚨Less than a week left to apply (deadline 19/03/25) for this exciting fully funded 4 Year Phd position in my group. Multidisciplinary project on the design of novel metallo-NBTIs including all the fun of chemistry and much more! Please RT! Apply here: www.crick.ac.uk/careers-stud...
If you're looking to do a PhD in bioinorganic and medicinal chemistry in a wonderful research group at a world-leading institute, here's a great opportunity: www.crick.ac.uk/careers-stud... @jeanninehess.bsky.social
Hess Lab | Metal-based Heterobifunctional Scaffolds to Capture Challenging Proteins
crick.ac.uk
Great transition into the new year with a well-organised party...
Thanks @cambridgeindy.bsky.social for publishing my view on closing the Mill Road Bridge for private vehicles.
"Prioritizing family life has earned me respect in my field — and my research has improved, too" www.nature.com/articles/d41...
What it means to be a successful male academic
Prioritizing family life has earned me respect in my field — and my research has improved, too, says Dritjon Gruda. Prioritizing family life has earned me respect in my field — and my research has imp...
nature.com
Quite faint in the middle of town, but one could clearly see the northern lights in Cambridge, UK.
You wouldn’t think that formaldehyde is an actual cellular signaling molecule, would you? But here we are!
Formaldehyde, You Say?
science.org
This report on the CACHE competition is worth a read. It’s about as close as we’ve gotten to some open benchmarking of AI impact to the drug discovery process. I’d suggest a title change to “When Can AI Deliver the Drugs?” though. A few more thoughts👇 1/
When can AI deliver the drug discovery hits?
The CACHE hit-finding competition highlights the potential of AI to identify small molecules that bind to hard-to-drug targets — and the long road ahead for these computational screening approaches. T...
nature.com
Absolutely agree. And I only play the nice guy on here, but reality might be closer to this meme:
"Then they took the extra step, rarely realized in such papers [...], of actually synthesizing hundreds of the hit molecules and experimentally testing them against the real proteins. (Faint cheers can be heard echoing from the lab benches and fume hoods)." 😅
Derek Lowe@dereklowe.bsky.social · 3y agoUsing AlphaFold protein models to screen against has been looking like not-so-great idea. But it might work better than you'd have thought: 🧪 Chemsky www.science.org/content/blog...
We should spend a massively less amount of time politically kneecapping our most globally competitive export industry that employs more than 2% of the entire US workforce
Brendan Nyhan@brendannyhan.bsky.social · 3y agoShocked at how high this is: "About one in 40 U.S. workers draws a paycheck from a college or university" www.wsj.com/us-news/educ...
Towards a better society by limiting wealth accumulation? A great take on Ingrid Robeyns' Limitarianism: www.theguardian.com/books/2024/j...
‘No one should have more than €10m’: the author of Limitarianism on why the super-rich need to...
Prof Ingrid Robeyns has spent a decade studying wealth and ethics and says that limits are essential if we want to eradicate poverty and protect social cohesion and the planet
theguardian.com
