Ian McGough 🇪🇺🇮🇪🪰

@ianmcgough.bsky.social

Group Leader @BabrahamInst Cambridge. Interested in #MorphogenSignalling #CellBio #Wnt #Hedgehog #BMP #Drosophila 🪰

Looking forward to an exciting meeting and congrats to Yeonjoo from @babrahaminst.bsky.social on being selected to speak in the ECR slot.

WntUK@wntuk.bsky.social · 2y ago

Registration and abstract submission is now open for the #WNT2025 meeting at @ox.ac.uk in Mar 2025 sponsored by @oxfordcancer.bsky.social and @cambridgebio.bsky.social. Join links below and lets showcase the best Wnt research the UK has to offer! www.oxforduniversitystores.co.uk/conferences-...

Excited about our pre-print on AXIN1 mutations in HCC! We found that AXIN1 mutations drive low but physiologically relevant levels of Wnt/β-catenin signaling, while being permissive to YAP/TAZ activation. This helps explain why mutations in AXIN1 and β-catenin are linked to distinct HCC subtypes.

bioRxiv Cancer Bio@biorxiv-cancer.bsky.social · 2y ago

Hepatocellular carcinoma-associated AXIN1 mutations drive low levels of Wnt/β-catenin pathway activity that allow for niche-independent growth and YAP/TAZ signaling https://www.biorxiv.org/content/10.1101/2024.11.28.625941v1

Please welcome us to BlueSky and give us a follow! We are newly formed UK scientific society with interests in the structural, molecular and cellular mechanisms of Wnt signalling in development and disease. We are represented by all four corners of the UK and cover all aspects of Wnt signalling!

Bild

Delighted to announce a new call for applications for our Pathway to Independence programme. Now entering its third year, this scheme supports postdocs going on the job market in 2025 - with training, mentorship, profile-raising and networking opportunities. Application deadline 31 Jan 2025. 1/3

PI programme | Development | The Company of Biologists

PI programme | Development | The Company of Biologists Development's Pathway to Independence programme Development is excited to announce our call for our Pathway to Independence program...

journals.biologists.com

Our new preprint is out - please share! We asked: How can we make CRISPR knockouts in vivo more efficient? And set up an assay that enables detection of CRISPR cutting with 100s-1000s of sgRNAs over entire chromosome arms in living animals. Grab a ☕ and let’s dive in. 🧵🧪 1/n #CRISPR #geneediting