Tessera

Seema Grewal

@seemagrewal.bsky.social

Executive Editor at Journal of Cell Science (@jcellsci.bsky.social) - a community journal published by The Company of Biologists (@biologists.bsky.social), a not-for-profit organisation. #cellbiology #cellbio 🧪👩🏻‍🔬 https://journals.biologists.com/jcs

81 Posts2370 Follower 787 Folgt

Journal of Cell Science @jcellsci.bsky.social · 11h ago

We invite you to submit your latest research to our upcoming special issue: Proteostasis. This issue will be coordinated by two of our Academic Editors: Pedro Carvalho and Tamotsu Yoshimori. journals.biologists.com/jcs/pages/pr...

Journal of Cell Science @jcellsci.bsky.social · 6d ago

Richa Maheshwari, Orna Cohen-Fix @ornacf.bsky.social and colleagues find that the C. elegans centriculum, a centrosome-associated membrane reticulum, may act as a filter, limiting microtubule growth. #OpenAccess journals.biologists.com/jcs/article/...

Figure showing the spatial relationship between the centrosome, centriculum and peri-centrosomal microtubules.

Journal of Cell Science @jcellsci.bsky.social · 3d ago

Issue 14 is complete Explore our Toc: journals.biologists.com/jcs/issue/13... Our cover image shows annulate lamellae at ER–mitochondria contact sites, marked by Nup358 (green) and mitochondria (magenta). See article by Oliveira & Joseph. journals.biologists.com/jcs/article/...

$JCS cover: Annulate lamellae (AL) at endoplasmic reticulum (ER)–mitochondria contact sites (ERMCSs). Super-resolution image of HeLa cells showing Nup358-positive structures (green) and mitochondria (magenta). In addition to its localization at nuclear pore complexes (prominently concentrated around the nucleus at the centre of the cell), Nup358 is present in cytoplasmic AL, specialised ER subdomains enriched with a subset of nucleoporins. A fraction of these AL structures is closely associated with mitochondria, indicating their localization at ER–mitochondria contact sites (ERMCSs). Images were acquired using a Nikon Eclipse Ti2 microscope equipped with the CREST Optics DeepSIM X-Light super-resolution imaging module. Picture credit: Gowhith Kuppili. See article by L. Oliveira and J. Joseph. (jcs264633).$

Pastor-Pareja Lab @pastorparejalab.bsky.social · 2d ago

Our new study on how endoplasmic reticulum exit sites are formed is out in @jcellsci.bsky.social: "Cooperative definition of ER exit sites by Tango1, Sec16 and Sec12" journals.biologists.com/jcs/article/...

David Breslow Lab @davidbreslowlab.bsky.social · last mo.

Excited to share our review article on cilia disassembly, published in @jcellsci.bsky.social. journals.biologists.com/jcs/article/.... We highlight how disassembly of cilia occurs, ...

Primary cilium disassembly – from mechanisms to roles in physiology and disease

Summary: This Review explains how recent advances have expanded our models of how, when and where primary cilia disassemble and discusses emerging roles of altered disassembly in disease.

journals.biologists.com

Journal of Cell Science @jcellsci.bsky.social · last wk.

In their Opinion article, Hemmo Meyer @hemmo-lab.bsky.social @unidue-zmb.bsky.social, Akiko Kuma and Shuhei Nakamura discuss the concept of lysosome regeneration and provide guidance for interpreting markers and assays used to study lysosomal damage responses. journals.biologists.com/jcs/article/...

Schematic showing the diverse pathways in the lysosomal damage response.

Journal of Cell Science @jcellsci.bsky.social · last wk.

Igor Yakunin, Sean Munro @cellbiol-mrclmb.bsky.social and colleagues find that the Golgi vesicle tether p115 can bind directly to the ER exit site organiser Sec16A. #OpenAccess #ReadandPublish journals.biologists.com/jcs/article/...

AlphaBridge visualisation of the output from an AlphaFold 3 prediction of a complex between the N-terminal region of Sec16A (1–1100) and the head domain of p115 (1–630). Shown in orange and blue are the two high-confidence interactions identified by AlphaBridge, both of which have a predicted interaction confidence score (piCS) of 0.91 (Álvarez-Salmoral et al., 2025 preprint). The predicted local distance difference test (pLDDT) score of ≤50 indicates that most of the indicated region of Sec16A is predicted to be unstructured. (C) AlphaFold 3 prediction of the complex formed between residues 701–755 of Sec16A and the head domain of p115. The residues of Sec16A lie along a groove in the surface of p115, with two regions predicted to interact with very high confidence. Shown in red are short stretches of residues in the middle of each region that were selected for mutation to alanine.

The Company of Biologists @biologists.bsky.social · 5d ago

We now have 4,426 trees for published articles and 12,662 trees for peer reviews in The Forest of Biologists. Thank you to everyone who has contributed.

Journal of Cell Science @jcellsci.bsky.social · last wk.

Carolyn Ott @hhmijanelia.bsky.social, Jennifer Lippincott-Schwartz & David Breslow @davidbreslowlab.bsky.social explain how recent advances have expanded our models of primary cilia disassemble and discuss emerging roles of altered disassembly in disease. journals.biologists.com/jcs/article/...

Schematic showing the mechanisms contributing to cilia disassembly.

Quentin Frenger @frengerquentin.bsky.social · last wk.

Happy to share that our study is now published @jcellsci.bsky.social ! doi.org/10.1242/jcs....

Vimentin intermediate filaments support autophagosome biogenesis at ER–endosome contact sites in response to starvation

Highlighted Article: Vimentin intermediate filaments rapidly reorganize to mobilize ER–endosome contact sites, establishing a crucial spatial platform for starvation-induced autophagy initiation.

doi.org

Quentin Frenger@frengerquentin.bsky.social · 8mo ago

My first postdoc preprint is out! Upon starvation, the Vimentin IFs network rapidly compacts (in <15 min!) to "cage" ER-Endosome membrane contact sites. This spatial confinement is crucial for autophagosome biogenesis. www.biorxiv.org/content/10.6... #CellBiology #Autophagy #Vimentin

The Company of Biologists @biologists.bsky.social · last wk.

Journal of Cell Science @jcellsci.bsky.social invite you to submit your latest research to their upcoming special issue: Proteostasis. This issue will be coordinated by two JCS Academic Editors: Pedro Carvalho and Tamotsu Yoshimori. Find out more at tinyurl.com/2s3uk7rz

Kate Miroshnikova @katemiro.bsky.social · 2w ago

🤩🤩🤩It was a pleasure & a lot of fun, as always, to work with @jcellsci.bsky.social on this - congratulations on a fantastic issue all about the #nucleus 😎😎😎

Journal of Cell Science@jcellsci.bsky.social · 2w ago

We spoke to Kate @katemiro.bsky.social about her ‘random walk’ into cellular biophysics, how AI might uncover links between nuclear morphodynamics and cell fate hiding in plain sight, and fishing for crayfish as a child growing up in Kazakhstan. journals.biologists.com/jcs/article/...

Kate and her ‘girls’ – mom and granny, wine tasting from test tubes somewhere around Washington, D.C. Through their constant love, kindness and support, these two trailblazer women in their own rights have always been my strength and super-power.

Journal of Cell Science @jcellsci.bsky.social · 2w ago

In this Review, Coral Zhou dissects the causes and consequences of genome size variation from the perspective of 3D genome organisation. journals.biologists.com/jcs/article/...

Cartoon speculating how changes in genome size are reflected at the level of single nucleosomes, TADs and subnuclear compartmentalisation. How do genomes adapt to changes in size? As genomes get bigger, their organization in 3D space dramatically shifts in ways we do not understand, likely requiring innovations at the molecular scale in order to maintain the same functions. Here we speculate on these changes at the level of single nucleosomes, TADs and subnuclear compartmentalization. (A) Based on previous work in Drosophila suggesting that heterochromatin machinery is titrated with increasing genome content (Dimitri and Pisano, 1989), we speculate that H3K9me3, an epigenetic mark associated with heterochromatin, will be less abundant on newly polyploid genomes. (B) Based on some evidence from axolotl (Schloissnig et al., 2021), we also hypothesize that TADs will generally scale with increasing genome size. (C) As genomes get bigger, nuclei also grow, resulting in a decrease in the ratio between nuclear surface and nuclear volume. Since the nuclear envelope is the source of many nuclear activities, including nuclear transport and communication with the endoplasmic reticulum, we speculate that major changes in nuclear shape and an increase in NPCs are required to accommodate a bigger genome. We also hypothesize that membraneless subnuclear compartments such as the nucleolus and heterochromatin domains will scale with genome size, and it will be interesting to measure how these changes affect ribosomal RNA production and gene silencing, respectively. Created in BioRender by Zhou, C., 2026. https://BioRender.com/6dz6avq. This figure was sublicensed under CC-BY 4.0 terms.

Journal of Cell Science @jcellsci.bsky.social · 2w ago

In this Opinion article, Peter Cook looks at the impact of clusters of RNA polymerases in linking DNA sequence and cell fate. journals.biologists.com/jcs/article/...

Waddington landscapes and transcriptional noise. Iconography adapted from Waddington (1957) and Urban and Johnston (2018). (A) Example landscape. Top, a stem cell (blue ball) differentiates as it rolls down through the landscape towards different valleys leading to different cell fates, presented here as fibroblast, myoblast or neuron. Bottom, according to the traditional model, individual lineage-specific genes are transcribed in different local minima. (B) Transcriptional noise is visualized as a transient ‘speed bump’ that diverts a fibroblast progenitor incorrectly down the myoblast path. (C) Increasing valley depth mitigates the effect of a speed bump. (D) Clusters will be in deeper minima, mitigating effects of transcriptional noise.

Journal of Cell Science @jcellsci.bsky.social · 2w ago

Did you know that JCS publishes Short Reports? These articles (of up to 3000 words and 4 display items) report a significant finding that furthers our understanding of cell biology and provides the foundation for future studies. Find out more: journals.biologists.com/jcs/pages/re... #notforprofit

Journal of Cell Science @jcellsci.bsky.social · 2w ago

Haritha Prabha, Priscilla Phan and Daniel Levy review the emerging mechanisms regulating nuclear scaling and morphology. journals.biologists.com/jcs/article/...

Cartoon showing the regulators of nuclear size. (A)A variety of different biophysical forces are thought to act on the nucleus. Nucleocytoplasmic transport dictates the proteomes of the nucleoplasm and cytoplasm, which each give rise to different densities & osmotic pressures in these two compartments. Lower density in the nucleoplasm correlates with higher macromolecular diffusion rates. The NE is viscoelastic, which allows for NE growth while also producing membrane tension that can restrict growth. Weakening of the NE can cause membrane blebs that rupture & repair, also affecting nuclear size and shape. The overarching model is that the magnitude of these different biophysical forces and how they balance each other determine steady-state nuclear size in different cell types, developmental stages & organisms. However, in many instances, rigorous testing of this model awaits future investigation. (B) LINC complexes mediate interactions between the lamina & chromatin inside the nucleus & the actin & microtubule (MT) cytoskeletons in the cytoplasm, producing mechanical forces on the NE that affect nuclear size & shape. Additionally, force produced by intranuclear F-actin can drive nuclear growth and cytoplasmic vimentin filaments can resist NE deformation. (C) Other NE components that mechanically influence nuclear size include lamins and lamin–histone interactions, heterochromatin-binding proteins and lipid composition. (D) Chromatin is another mechanical effector that produces force on the NE. Chromatin forces are influenced interdependently by chromatin amount, histone modifications, chromatin compaction and stiffness, chromatin topology, chromatin-associated RNAs and protein condensates. H3K9ac, histone H3 acetylated at K9; H3K9me, histone H3 methylated at K9; H3K4me3, histone H3 trimethylated at K4; H3K27me3, histone H3 trimethylated at K27. Created in BioRender. Prabha, H., 2026. https://BioRender.com/5qy8f5g. This figure was sublicensed under CC-BY 4.0 terms.

Rachel Lee, PhD @scientistrachel.bsky.social · 3w ago

Finally, I have to shout out the @biologists.bsky.social Forest of Biologists initiative for planting a holly tree to go with this paper! forest.biologists.com/landscape/?i... (7/7)

Landscape - The Forest of Biologists

forest.biologists.com

Rachel Lee, PhD @scientistrachel.bsky.social · 3w ago

Microscopy beautifully reveals the dynamic nature of biology but quantifying that motion can be tricky! In the latest paper from @aicjanelia.bsky.social, out now in @jcellsci.bsky.social, we present a tool for measuring amorphous motion: OpticalFlow3D journals.biologists.com/jcs/article/... (1/7)

OpticalFlow3D – a tool for measuring amorphous motion in three-dimensional fluorescence microscopy images

Summary: Biological motion can be difficult to define and measure. Optical flow is uniquely suited to this challenge. We provide tools for 3D optical flow and illustrate its use in extracting biologic...

journals.biologists.com

Journal of Cell Science @jcellsci.bsky.social · 2w ago

This article is associated with a field mapletree, planted in The Forest of Biologists. forest.biologists.com/landscape/

Tree no. 15506
Field maple (Acer campestre)

Sturdy broad-leaved deciduous tree, with a wide ecological range and natural distribution over most of Europe. Field maple has a light brown and flaky bark, with brown slender twigs that develop corky ridges with age. Its small, dark-green leaves have five lobes with rounded teeth, and fade to a rich golden-yellow or red before falling in autumn. A hermaphroditic species – its small, yellow-green, clustered flowers are pollinated by insects and develop into large, winged crimson fruits (samaras) that are dispersed by wind.

Field maple has a compact habit and grows in woods, scrub and hedgerows. While extremely tolerant to shade during the first decade, its light requirements are higher in seed-bearing years. It prefers warmer climates, but can also tolerate hard winters. Highly resistant to air pollution, the trees are widely planted in gardens and parks.

Journal of Cell Science @jcellsci.bsky.social · 2w ago

In their Review, Alexandra Edwards and Elizabeth Finn discuss how genome organisation underlies evolution and development. journals.biologists.com/jcs/article/...

Schematic showing evolutionary diversity in genome organisation

Maria Bohnert Lab @bohnertlab.bsky.social · last mo.

Our @jcellsci.bsky.social poster article “The nucleus-vacuole junction at a glance” is out! Big thanks to @abbybuch.bsky.social and @luskinglab.bsky.social for organizing an amazing special issue “Cell biology of the nucleus”. #ContactSites journals.biologists.com/jcs/article/...

The nucleus–vacuole junction at a glance

Summary: The nucleus–vacuole junction is a prominent contact site linking the nuclear ER and the yeast vacuole. We highlight the physiological implications and metabolic plasticity of this unique orga...

journals.biologists.com

Warmflash lab @warmflashlab.bsky.social · 4w ago

Reach out if you have questions about JCS! The journal has a long history of publishing outstanding science and supporting the research community.

Journal of Cell Science@jcellsci.bsky.social · 4w ago

Working on stem cell biology? Our expert Academic Editor, Aryeh Warmflash (@warmflashlab.bsky.social), handles articles on this topic so send your article our way. It's FREE to publish in JCS and we're not-for-profit. Find out more: journals.biologists.com/jcs/pages/re... #stemcells #ISSCR2026

Journal of Cell Science @jcellsci.bsky.social · 3w ago

*It's happening today* Don't miss the summer webinar from the Nuclear Pore and Nuclear Transport series featuring research from our Special Issue: Cell Biology of the Nucleus. focalplane.biologists.com/2026/07/06/j...

FocalPlane @focalplane.bsky.social · last mo.

For all the #nucleus fans out there: We’re celebrating the latest @jcellsci.bsky.social Special Issue in a webinar hosted by the Nuclear Pore and Nuclear Transport webinar series. Join us to hear talks from Ayse Turkmen, @andrewdstephens.bsky.social & Ralph Kehlenbach. 🗓️13 July, 17:00 BST (UTC+1)

The Downs Lab @thedownslab.bsky.social · 3w ago

So nice to see Pierre's @pierrecaron.bsky.social highlight of our preprint (led by @lillianwu.bsky.social ) was selected by @jcellsci.bsky.social to include in their latest issue. Also, what a great initiative - ended up reading them all! prelights.biologists.com/highlights/c...

CENP-B binds hairpin motifs in chromosome arms influencing gene expression - preLights

CENP-B escapes the centromere and plays a surprising role in gene regulation

prelights.biologists.com

The Company of Biologists @biologists.bsky.social · 4w ago

Are you attending #ISSCR2026 in Montreal this week? Visit our stand to complete our quick survey and be in with a chance of winning a special goodie bag.

Journal of Cell Science @jcellsci.bsky.social · 4w ago

You can find out more about Aryeh in this recent interview with him: doi.org/10.1242/jcs.... #stemcells #ISSCR2026

Interview with Associate Editor Aryeh Warmflash

ABSTRACT. Aryeh is an Associate Professor of BioSciences and a CPRIT Scholar in Cancer Research at Rice University, Houston, Texas, USA. Aryeh graduated with a bachelor's degree in physics and mathema...

doi.org

The Company of Biologists @biologists.bsky.social · 4w ago

We’re all set up for #ISSCR2026. Come and see us in the exhibition hall at Booth 1005 to find out about our journals and for info about our charitable grants and Workshops, as well as for free special issues, posters and giveaways.

preLights @prelights.bsky.social · 4w ago

Exciting #preprints in nuclear cell biology. As part of the latest Special Issue in @jcellsci.bsky.social, this article bundles together relevant #preLights. preLighters involved include @pierrecaron.bsky.social, Abby, Reinier @sristi.bsky.social & Filipe journals.biologists.com/jcs/article/...

Preprint highlights in nuclear cell biology

This article features recent preLights that discuss preprints relevant to this ‘Cell Biology of the Nucleus’ special issue.preLighterPierre Caron, CNRS researcher at the Institute of Structural Biolog...

journals.biologists.com