Thrilled to see this work published! Dr. Pierre and @angelopilotti.bsky.social developed an accessible flow-cytometry approach that simultaneously profiles all three branches of the Unfolded Protein Response (UPR) in nuclear suspensions at single-cell resolution. Congrats to all authors!

Angelo Pilotti@angelopilotti.bsky.social · last mo.

🎉 New paper out! We developed SNUPR, a flow-cytometry approach that profiles all three branches of the Unfolded Protein Response (UPR) at single-cell resolution in nuclear suspensions. 📄 doi.org/10.1038/s443... @embomolmed.org @ciml.bsky.social @cnrs.fr @univ-amu.fr

🚀 Looking for a postdoctoral opportunity with real impact? The #COFUND BEYOND call is now open — an international MSCA programme led by Fondazione Telethon. 🔬 35 fully funded postdoctoral fellowships in advanced therapies 📅 Apply by June 30th, 2026 👉 www.beyond-cofund.eu

🚀 We’re Hiring! 16 PhD opportunities in experimental hemato-oncology! Are you ready to translate fundamental discoveries into innovative therapeutic strategies and diagnostic tools? 🔗Learn more & apply now: achilles-dn.eu #PhD #CancerResearch #MSCA #HematoOncology

🚀 Day 3 of the IMMERGE Workshop! Today we’re diving into career paths, innovation, and entrepreneurship. We’re thrilled to have qGenomics and Alia Therapeutics leading today’s sessions and sharing their real-world experience at the interface of science and industry. Great conversations ahead! 💡

🔬 Day 2 of the IMMERGE Workshop! We’re back for another full day of science at OSR. Today’s program features insightful talks from Dr. Roger Geiger and Dr. Roser Vento-Tormo, bringing their expertise to our doctoral researchers. Loving the energy and curiosity in the room! 🚀

🔬IMMERGE News! Our Gene Editing Technologies & Innovation, transfer, and Entrepreneurship workshops kicked off this morning at Ospedale San Raffalle in Milan! A huge thank you to @dimiccolab.bsky.social and Anastasia Conti for the warm welcome and support in hosting us!💡🧬

🌍 IMMERGE beyond the lab! On Sept 20, @angelopilotti.bsky.social (Pierre's lab) spoke at a conference in Fondi, Italy—organized by local associations to bring science closer to the public. 👏 He talked about autoimmune diseases & shared PhD insights on stress responses and immunity #IMMERGE #MSCA

🌟#IMMERGE 2025 PI spotlight! @dimiccolab.bsky.social at OSR reveals how CRISPR-Cas9 in HSCs can trigger senescence-like responses, & provides optimized protocols to preserve edited cells long-term! 1️⃣ pubmed.ncbi.nlm.nih.gov/40466639/ 2️⃣ pubmed.ncbi.nlm.nih.gov/40173037/ More highlights coming soon🚀

👏 Proud moment for #IMMERGE! Our DC7 fellow Hanna Norbäck co-chaired a session at the 2025 DBM Summer Symposium (@unibas.ch) together with Dr. Zaugg. 🌟 A great day of science, collaboration & inspiring talks! 🧪🔬 #DBMSymposium2025 #TeamDBM #AcademicLife #Science #IMMERGE

🌟 #IMMERGE 2025 PI spotlight: Prof. Warnatz on immunodeficiencies! Exploring T & B cell changes, unique glycosylation, & risk factors for premature mortality: 1️⃣ pubmed.ncbi.nlm.nih.gov/40496855/ 2️⃣ pubmed.ncbi.nlm.nih.gov/40090481/ 3️⃣ pubmed.ncbi.nlm.nih.gov/40013136/ More highlights coming soon!🚀

New paper alert – now in @ScienceAdvances Congrats to IMMERGE PI José Luís Sardina and team!🎉 This study shows how targeted DNA methylation editing at a key immune gene can reshape cell fate and immune responses. 📷 Read more: pubmed.ncbi.nlm.nih.gov/40668918/ #IMMERGE #MSCA #CRISPR #epigenetics

🧬 New in Nature Methods! Congrats to IMMERGE PI Judith Zaugg and team on SUM-seq—a new ultra-high-throughput multiplexed sequencing for profiling chromatin accessibility & gene expression in single nuclei. Tested in macrophages, T cells & iPSCs! 📖 Find out more: tinylink.net/a3PNE #IMMERGE #MSCA

Single-cell ultra-high-throughput multiplexed chromatin and RNA profiling reveals gene regulatory dynamics - Nature Methods

This work presents SUM-seq, an ultra-high-throughput method for co-profiling chromatin accessibility and gene expression in single nuclei across multiplexed samples, advancing the study of gene regula...

doi.org

🚨PhD Opportunity Alert! The second NUCLEAR network recruitment call is now open! Don’t miss out! #PhD #MSCA #NUCLEARnetwork #GeneRegulation #ScientificCareers #HorizonEurope #EUresearch #Immunology

NUCLEAR-DN@nucleardn.bsky.social · last yr.

🚨 2nd Recruitment call is now open! 🚨 ⚠️There are still 3 Doctoral Candidate positions available in NUCLEAR! Don't miss this oportunity! If you're ready to dive into innovative research in metabolic regulation of genome, join our international program. 📩Apply now: nuclear-dn.eu/recruitment/

🚀The IMMERGE consortium met in Heidelberg for our 2nd training event & Midterm Review! DCs joined sessions on: 🔬Epigenetic & Transcriptional Regulation 🧠Leadership & Management Huge thanks to all involved—and to @embl.org for hosting us! 🌍Next stop: Milan! 👉 immergeproject.eu #IMMERGE #MSCA

Busy and inspiring week at @embl.org for the @immerge.bsky.social midterm review and two great workshops: #Epigenetics & #TranscriptionalRegulation, and #Leadership & #Management. Grateful for the science, the insights, and everyone’s commitment !

🔵New paper alert🔵 ❗️Barros and Ferreira show that induction of the ISR by SubAB drives type-I IFN expression in pDCs via STING 🎉Glad to have contributed to this work. Thanks to Philippe Pierre and @immerge.bsky.social 👉🏻Full article on @pnas.org at www.pnas.org/doi/10.1073/pnas.2421258122

🔬 Meet the Researchers Behind IMMERGE! 🔬 This week: Renata Chalupska & Dr. Saka from @embl.org 🧬 Renata investigates how immune monogenic syndromes impact blood cell development. That’s a wrap on our IMMERGE series—13 brilliant researchers shaping immunology’s future! 🌍👏 #IMMERGE #MSCA #IEI

🔬 Meet the Researchers Behind IMMERGE!🔬 This week: Martí Leira & Dr. Vento-Tormo from @sangerinstitute.bsky.social!🧬 Martí explores novel regulators of Tregopathies to better understand immune dysregulation and its roots. Stay tuned for more IMMERGE scientists! 🚀 #IMMERGE #MSCA #IEI

🔬 Meet the Researchers Behind IMMERGE! 🔬 This week: Eric O'Shee & Dr. Geiger from IRB! 🧪✨ Eric studies how mutations linked to Treg dysfunction impair immune suppression, disrupt immune tolerance, and contributing to autoimmunity. Stay tuned for more IMMERGE scientists! 🚀 #IMMERGE #MSCA #Tregs

🔬 Meet the Researchers Behind IMMERGE! 🔬 This week: Franka Witthauer & Dr. Casini from Alia Therapeutics! ✨ Franka works on correcting mutations linked to primary immunodeficiencies using innovative, engineered CRISPR tools.👩‍🔬 Stay tuned for more IMMERGE scientists! 🚀 #IMMERGE #MSCA #IEI #CRISPR

📢Looking for a #postdoc in blood cancers? The CarrerasLeaders Call 4 is OPEN for exceptional applicants at @carrerasijc.bsky.social. 📅 Apply by June 1, 2025 ✨World-class researchers supervision ✨International secondments ✨Top-tier research infrastructures More details at carrerasleaders.eu

🔬 Meet the Researchers Behind IMMERGE! 🔬 This week: Tharaa Mohammad & Dr. Rodriguez from qGenomics! 🧬 Tharaa studies how JAK/STAT and NF-κB signaling contribute to immune-related preeclampsia, uncovering maternal-fetal immune dynamics. Stay tuned for more IMMERGE scientists! 🚀 #IMMERGE #MSCA #IEI

🔬 Meet the Researchers Behind IMMERGE! 🔬 This week: Florence Melbert, @eballestar.bsky.social & @jlsardinalab.bsky.social from @carrerasijc.bsky.social! Florence is studying how IKAROS mutations contribute to IEI.👩‍🔬 Stay tuned for more IMMERGE scientists! 🚀 #IMMERGE #MSCA #IEI #IKAROS

🔬 Meet the Researchers Behind IMMERGE! 🔬 This week: Hanna Norbäck & Dr. Zaugg from @unibas.ch✨ Hanna is developing a framework to map cell-type-specific mutation effects, enhancing our understanding of immune dysregulation. Stay tuned for more IMMERGE scientists! 🚀 #IMMERGE #MSCA #IEI

🧬 New Review Alert! Dr. Boisson-Dupuis just published this review on how monogenic inborn errors of immunity shape susceptibility to infectious diseases, shedding light on key immune defense mechanisms. A must-read for immunologists! 👉 tinyurl.com/27av65jh #IEI #Immunology #InfectiousDiseases

The monogenic landscape of human infectious diseases

The spectrum of known monogenic inborn errors of immunity is growing, with certain disorders underlying a specific and narrow range of infectious dise…

tinyurl.com

🔬 Meet the Researchers Behind IMMERGE! 🔬 This week: Andrea Carpinteiro & Dr. Di Micco from OSR! 🧬 Andrea explores how dysfunctional telomeres impact stem cells & immunity, revealing links between aging and immune regulation. Stay tuned for more IMMERGE scientists! 🚀 #IMMERGE #MSCA #IEI #Telomeres

🔬 Meet the Researchers Behind IMMERGE!🔬 This week: Laura Artal & Dr. Klaus Warnatz from @uni-freiburg.de! Laura will focus on IKBKB deficiency, aiming to uncover its impact on patients with immunodeficiencies 🧬✨ Stay tuned for more IMMERGE scientists! 🚀 #IMMERGE #MSCA #IEI #Immunology #IKBKB

🔬Exciting IMMERGE research in action! 🔬 IMMERGE PhD fellow @angelopilotti.bsky.social presented his work at the PhD workshop at @ciml.bsky.social! 📊✨ Great to see our researchers sharing knowledge & advancing the field! 👏 #IMMERGE #MSCA #IEI #Immunology #ISR #DendriticCells #SLE #SAVI

Angelo Pilotti@angelopilotti.bsky.social · last yr.

🔬 Exploring the role of the Integrated Stress Response in dendritic cells and interferonopathies 🔬 📊Last week, I had the opportunity of presenting my research project during the PhD workshop at @ciml.bsky.social. (1/7)

🔬 Meet the Researchers Behind IMMERGE! 🔬 This week: Giulia Bressan & Dr. Bodo Grimbacher from @uni-freiburg.de! Giulia will dive into STAT3 regulation & signaling to better understand immune function👩‍🔬🌟 Stay tuned for more IMMERGE scientists! 🚀 #IMMERGE #MSCA #IEI #Immunology #STAT3

Drawing inspiration from the tardigrade, researchers developed a new strategy that may protect cancer patients from the side effects of radiation therapy. www.nature.com/articles/s41...