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Esteban Ballestar

@eballestar.bsky.social

Research Team Leader working on Epigenetics & Immunity | Barcelona https://www.carrerasresearch.org/en/research/epigenetics-and-immune-disease

20 Posts310 Follower220 Folgt
Esteban Ballestar@eballestar.bsky.social · 4w ago

Don't miss this event! Take a look at our outstanding speaker lineup!

Josep Carreras Leukaemia Research Institute@carrerasijc.bsky.social · 4w ago

📢 Registration is now open for the IJC Symposium 2026! Join us on 5–6 Nov in Barcelona to explore the latest advances in the immunology of haematological malignancies and future therapies for blood cancers. 🧬 Free registration 📄 Abstract submissions open 🔗 carrerasresearch.org/en/p/immunit...

Esteban Ballestar@eballestar.bsky.social · 4mo ago

Wonderful work, David! The concept that ETC flux—not ATP—licenses cDC1 immunogenicity through /metabolite control of DNA methylation is conceptually beautiful. Congrats to Ignacio, Stefanie and the whole team! Thanks for giving us the chance to learn throught this collaboration!

David Sancho@sancholab.bsky.social · 4mo ago

🤔Do you think that OXPHOS in DCs = tolerance? In our new @cp-cellmetabolism.bsky.social #cnic_cardio & @irbbarcelona.org, we show that active #mitochondrial ETC primes cDC1s for immunogenicity, not tolerance. Life (& #immunometabolism) is not simple ⚡️ OPEN: www.cell.com/cell-metabol... #immunoSky

Esteban Ballestar@eballestar.bsky.social · last yr.

We’re thrilled to have contributed to this outstanding work led by @jlsardinalab.bsky.social & Gemma Valcárcel! 🧬💡 This study is a milestone in showing that epigenetic editing can causally shape immune identity and inflammatory responses. @carrerasijc.bsky.social #Epigenetics #CRISPR #Immunology

Josep Carreras Leukaemia Research Institute@carrerasijc.bsky.social · last yr.

🚨New research by @jlsardinalab.bsky.social and Gemma Valcarcel published at Science Advances uses a CRISPR technology to control immune cell response to inflammation in the lab. 🔗 Read more: www.carrerasresearch.org/en/news/epig...

IMMERGE MSCA DN@immerge.bsky.social · last yr.

🧬 New in Nature Methods! Congrats to IMMERGE PI Judith Zaugg and team on SUM-seq—a new ultra-high-throughput multiplexed sequencing for profiling chromatin accessibility & gene expression in single nuclei. Tested in macrophages, T cells & iPSCs! 📖 Find out more: tinylink.net/a3PNE #IMMERGE #MSCA

Single-cell ultra-high-throughput multiplexed chromatin and RNA profiling reveals gene regulatory dynamics - Nature Methods

This work presents SUM-seq, an ultra-high-throughput method for co-profiling chromatin accessibility and gene expression in single nuclei across multiplexed samples, advancing the study of gene regula...

doi.org

Esteban Ballestar@eballestar.bsky.social · 2y ago

🚨 New paper alert 🚨 Our Human Microglia Atlas (HuMicA) characterizes #microglia subpopulations across 6 distinct #neurologic diseases. www.nature.com/articles/s41...

The Human Microglia Atlas (HuMicA) unravels changes in disease-associated microglia subsets across neurodegenerative conditions - Nature Communications

The Human Microglia Atlas includes 91,716 brain immune cells covering six neurologic pathologies. It characterizes the signatures of nine populations and describes the expansion of GPNMB-high microgli...

nature.com

BrunetLab@brunetlab.bsky.social · 2y ago

Thrilled to see this paper out!! 🧪 Spatial transcriptomics of brain aging and 'spatial aging clocks' identify cells that have pro-aging or pro-rejuvenating effects on their neighbors! Huge CONGRATS to Eric Sun and all authors! Fantastic collaboration with @jameszou.bsky.social! rdcu.be/d33uQ 🧵

Spatial transcriptomic clocks reveal cell proximity effects in brain ageing

Nature - A spatially resolved single-cell transcriptomics map of the mouse brain at different ages reveals signatures of ageing, rejuvenation and disease, including ageing effects associated with T...

rdcu.be

Eric Topol@erictopol.bsky.social · 2y ago

Why do some people, despite SARS-CoV-2 exposure, not develop an infection? An ultra-early interferon response blocks Covid www.thelancet.com/journals/ebi... adds to protection from pre-existing, cross-reactive T cells in some people

An ultra-early, transient interferon-associated innate immune response associates with protection from SARS-CoV-2 infection despite exposure

Our interferon-associated signature of early SARS-CoV-2 infection characterises a subgroup of exposed, uninfected contacts in three independent cohorts who may have successfully aborted infection prior to induction of adaptive immunity. The earlier transient upregulation of signature genes in PCR-negative compared to PCR-positive CHIM volunteers suggests that ultra-early interferon-associated innate immune responses correlate with, and may contribute to, protection against SARS-CoV-2 infection.

thelancet.com

immunoboys@immunoboys.bsky.social · 2y ago

IFNg stimulation induces SLAMF7 expression on myeloid cells in rheumatoid arthritis. SLAMF7 engagement (with recombinant SLAMF7) then leads to a strong increase in a large number of proinflammatory mediators. SLAMF7+ are found in a number of inflammatory conditions. 1/

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Renato Ostuni@ostunilab.bsky.social · 2y ago

IL-1 is SO RELEVANT in cancer 🔥 IL-1a released from dying tumor cells leads to myeloid cell recruitment and T cell suppression - targeting this pathway boosts efficacy of chemoTx and ICB Beautiful study by @ruffell-lab.bsky.social lab n Cancer Cell www.cell.com/cancer-cell/...

Interleukin-1α release during necrotic-like cell death generates myeloid-driven immunosuppression that restricts anti-tumor immunity

Hänggi et al. investigate how tumor necroptosis regulates anti-tumor immunity and find an unexpected role for interleukin-1α (IL-1α) release by dying cells in promoting tumor growth by driving recruit...

cell.com