It’s a bit late - but our work on Enhancement Targeting Chimeras (ENTACs) is out now! Check out our work describing how induced proximity of a DUB can stabilise short-lived receptor like CTLA4. @livuni-ismib.bsky.social

Life Science Alliance@lsajournal.org · 6mo ago

Exploring CTLA4 stabilization through the induced proximity of a deubiquitinating enzyme (DUB) offers a model for a detailed examination of DUB-target interactions, thereby enhancing ENTAC development strategies. #Biotech #Research www.life-science-alliance.org/content/9/4/...

Our latest preprint is out! We developed an inducible “RapTag” system that uses ENTAC to chemically recruit USP15 to the unstable protein CTLA4. This induced proximity stabilises and slows down the rapid lysosomal turnover of CTLA4. @livuni-ismib.bsky.social www.biorxiv.org/content/10.1...

Targeted recruitment of USP15 enhances CTLA4 surface levels and restricts its degradation.

Induced protein proximity offers powerful new routes to modulate protein fate. While proteolysis-targeting chimeras (PROTACs) promote degradation through E3 ligase recruitment, the converse principle-...

biorxiv.org

Excited to share the peer-reviewed version of our work, now online in @embojournal.org! Big thanks to our reviewers and @hvodermaier.bsky.social for facilitating this process. Looking forward to continuing this fun collaboration with @michaelnadbio.bsky.social! www.embopress.org/doi/full/10....

RNF114 and RNF166 exemplify reader-writer E3 ligases that extend K11 polyubiquitin onto sites of MARUbylation | The EMBO Journal

imageimageMARUbylation (mono-ADP-ribose ubiquitylation) is a multilayered post-translational modification controlled by PARPs and Deltex E3 ligases. This study identifies RNF114 and RNF166 as reader-w...

embopress.org

Jonathan Pruneda@jnpruneda.bsky.social · last yr.

Sharing the next installment of our fun collaboration with @michaelnadbio.bsky.social at the interface of #ubiquitin and #ADP-ribosylation! Building upon our identification of cellular MARUbylation, we now identify reader/writer E3 ligases that extend K11 polyUb! 🧵 www.biorxiv.org/content/10.1...

Our review "Proteostasis of immune checkpoint receptors" is out in Biochem J! @biochemsoc.bsky.social We highlight how ubiquitylation acts as a key sorting signal, governing the fate of immune checkpoints - from the highly stable PD-L1 to the short-lived CTLA-4. portlandpress.com/biochemj/art...

Delighted to share our work on cellular ubiquitination of drug-like compounds by HUWE1 - a surprising journey! Kudos to all contributors & first authors, Barbara Orth and Pavel Pohl. Sincere thanks to @ireserra.bsky.social ‬ #NatCommun for expertly guiding the winding publishing path. rdcu.be/eDzPk

Selective ubiquitination of drug-like small molecules by the ubiquitin ligase HUWE1

Nature Communications - Ubiquitination is a versatile modification system in eukaryotic cells. Here, the authors unveil that the ubiquitin ligase HUWE1 can modify drug-like small-molecule...

rdcu.be

📣 Calling all ubiquitin aficionados - one week to go before abstract deadline (July 18th)!! Join us on the coast in Lorne, Australia. www.lorneubiquitin.org #ubiquitin

Check out our study on the rapid turnover of CTLA4, featured in JCB Immune Cell Biology 2025 Collection!

Journal of Cell Biology@jcb.org · last yr.

@impeiyee.bsky.social, Clague, Urbé et al. characterize the role of #ubiquitin in the rapid turnover kinetics of the immune checkpoint protein CTLA4. rupress.org/jcb/article/... 📕 In Immune Cell Biology 2025: rupress.org/jcb/collecti... #AAI2025

We are sponsoring the Scottish Cell Biology Meeting on 18th Sept. Save the date!

Congratulations to Dr Pei Yee Tey (@impeiyee.bsky.social) from our Department of Biochemistry, Cell and Systems Biology, winner of the British Society of Cell Biology's 2025 Raff Medal for her research. ➡️ bit.ly/42evg4V #PhD | #BSCB | #TeamLivUni

Induced proximity modalities at the cell surface! Comprehensive review of emerging approaches and therapeutic possibilities by Carolyn Bertozzi and colleagues at Stanford! www.nature.com/articles/s41...

Induced proximity at the cell surface - Nature Biotechnology

Technologies to modulate induced proximity at the cell surface advance the manipulation of diverse biological responses.

nature.com

Thrilled to share our latest publication! We describe a novel acid-dependent mechanism regulating clathrin-independent endocytosis. This study was a fantastic collaborative effort with the labs of Ludger Johannes, Roberto Weigert, and Satyajit Mayor. nature.com/articles/s4155….

Ian Ganley delivering his Hooke Medal lecture on mitophagy at #biologists100 @biologists.bsky.social

Excited to see @lmcb-ucl.bsky.social alumna Pei Yee winning the Raff PhD Medal 2025. Also a very special prize named after Professor Martin Raff, a major driving force in the development of the LMCB four-year PhD programme. Read more about Pei Yee below 👇

British Society for Cell Biology@bscb-official.bsky.social · last yr.

Congratulations to our 2025 Raff PhD medal winner @impeiyee.bsky.social from @liverpooluni.bsky.social bscb.org/bscb-phd-awa...

Deeply honoured to receive the 2025 Raff Medal! Huge thanks to @bscb-official.bsky.social for the recognition. This wouldn’t have been possible without the support of my supervisors, Sylvie Urbé & Mike Clague, my colleagues, collaborators, and the many mentors who inspired me along the way.

British Society for Cell Biology@bscb-official.bsky.social · last yr.

Congratulations to our 2025 Raff PhD medal winner @impeiyee.bsky.social from @liverpooluni.bsky.social bscb.org/bscb-phd-awa...

Thrilled to share the structure of dimerised human PINK1 docked to an endogenous translocase array on the mitochondrial surface, composed of two TOM complexes, bridged by a VDAC2 dimer! Published today in Science www.science.org/doi/10.1126/... @wehi-research.bsky.social @komanderlab.bsky.social

Diverse routes to mitophagy governed by ubiquitylation and mitochondrial import www.cell.com/trends/cell-...

Diverse routes to mitophagy governed by ubiquitylation and mitochondrial import

The selective removal of mitochondria by mitophagy proceeds via multiple mechanisms and is essential for human well-being. The PINK1/Parkin and NIX/BNIP3 pathways are strongly linked to mitochondrial ...

cell.com

"Research is messy. … Trying to protect students from that reality does them a disservice." On #InternationalDayOfEducation, take a look back at this #ScienceWorkingLife on teaching students about scientific failure. https://scim.ag/3PLg8ER

🚀 Hot off the press! Our team findings @livuni-ismib.bsky.social on brain ageing unveil a novel connection between oxidative stress, neuronal microtubules, and the cytoskeletal protein EB1 driving neuronal atrophy. 🎉 A huge thank you to the fantastic team! www.aginganddisease.org/EN/10.14336/...

Happy to see this pre-print online where we supported volume EM needs of this collaborative effort led by the Booth lab to investigate the role of the chromosome periphery in meiosis vs mitosis. #liv-srf www.biorxiv.org/content/10.1... @livuni-livsrf.bsky.social @livuni-ismib.bsky.social

The Chromosome Periphery is an Essential Compartment of Oocyte Chromosomes

Chromosomes and their constituent compartments are core elements of the cell division machinery. In mammalian oocytes, defects in the structure or composition of chromosomes are a leading cause of abe...

biorxiv.org

Excited to share our latest preprint on @biorxivpreprint.bsky.social: "The RBR E3 ubiquitin ligase HOIL-1 can ubiquitinate diverse non-protein substrates in vitro". www.biorxiv.org/content/10.1...

The RBR E3 ubiquitin ligase HOIL-1 can ubiquitinate diverse non-protein substrates in vitro

HOIL-1 is a RING-between-RING (RBR)-family E3 ubiquitin ligase and component of the linear ubiquitin chain assembly complex (LUBAC). While most E3 ubiquitin ligases conjugate ubiquitin to protein lysi...

biorxiv.org

A new tool FUSEP profiles the E2-specific ubiquitome and enables systematic studies of non-lysine ubiquitin conjugation, here used to identify the existence of tyrosine ubiquitination www.nature.com/articles/s41...

E2–Ub-R74G strategy reveals E2-specific ubiquitin conjugation profiles in live cells - Nature Chemical Biology

Shen and Yin developed a technology named FUSEP to profile the E2-specific ubiquitome that makes use of a fusion between E2 and ubiquitin carrying a R74G point mutation, which leaves an LGGG remnant f...

nature.com

Our first educational project, DEGRADATOR, is now in the Journal of Chemical Education @acspublications.bsky.social Tested with 97 high school students, it enhances understanding of protein degradation. A step towards making molecular biology more accessible. Read more: pubs.acs.org/doi/10.1021/...

DEGRADATOR: A Gaming Expedition Into Targeted Protein Degradation Therapies

In an era of rapid scientific advancement, the need for engaging educational tools is critical. DEGRADATOR, a 2D computer game, bridges this gap by immersing players in the ubiquitin-proteasome system...

pubs.acs.org

My friend Victoria is joining the knitt/crocheting challenge this December to raise funds for @cancerresearchuk.org She created thoughtful science-inspired crochet gifts for our lab members (pics attached) Donate here if you'd like to support her cause! fundraise.cancerresearchuk.org/page/victori...

Exciting PhD opportunity with @mcmillanlab.bsky.social in @livuni-ismib.bsky.social Liverpool! Kirsty is a great scientist and an extremely pleasant person to work with. Come join us if you're interested in membrane trafficking and neurodegeneration!

Kirsty McMillan@mcmillanlab.bsky.social · 2y ago

I have a funded PhD studentship available to start in my new lab in 2025! If you are interested in Endosomal Biology, Astrocytes and Alzheimer’s Disease have a look: www.findaphd.com/phds/project... Please feel free to share.

🧪The Biologists @ 100 conference incorporates the BSCB and BSDB @bsdb.bsky.social Spring Meetings. View the cell and developmental biology programme and speakers at bit.ly/3B2uflr. Abstracts are due less than 2 weeks away. 📆Abstract due: 13 December #biologists100 #Devbio #cellbio