Job Opportunity at University of Leeds: Research Fellow in Neuroscience

Overview of the RoleAre you an ambitious researcher looking for your next challenge? Do you have an established background in Neuroscience? Do you want to further your career in one of the UK’s leadin...

jobs.leeds.ac.uk

Insulin controls olfactory gain at the first central synapse by regulating periglomerular neuron excitability

Sensory processing is dynamically tuned by internal state, yet how metabolic signals reshape the earliest stages of sensory circuits remains poorly understood. Here we identify a circuit mechanism by which satiety suppresses olfactory sensitivity at the first central synapse in the mouse olfactory bulb. Using a within-animal paradigm modelling fasted and glucose-induced sated states, we show that satiety impairs food-finding behaviour and reduces olfactory receptor neuron input to the olfactory bulb. Periglomerular (PG) cells, which co-express insulin receptors and the potassium channel Kv1.3, mediate this effect: insulin inhibits the low-voltage-activated Kv1.3 current in PG cells, increasing their spontaneous and odour-evoked activity. This heightened PG cell activity drives enhanced presynaptic inhibition of olfactory receptor neuron terminals, dampening sensory input before it reaches mitral cells. These findings establish insulin-dependent presynaptic inhibition of PG cells as a key locus of state-dependent sensory gain control. ### Competing Interest Statement The authors have declared no competing interest. Medical Research Council, https://ror.org/03x94j517, MR/V003747/1 Biotechnology and Biological Sciences Research Council, BB/ Z51679X/1

doi.org

Job Opportunity at University of Leeds: Research Fellow in Neuroscience

Overview of the RoleAre you an ambitious researcher looking for your next challenge? Do you have an established background in Neuroscience? Do you want to further your career in one of the UK’s leadin...

jobs.leeds.ac.uk

Perception and neural representation of intermittent odor stimuli in mice - Nature Communications

Animals navigate odor plumes by exploiting dynamic and intermittent cues. Here, the authors show that mice can discriminate among different fluctuating odor signals, and characterize their neural enco...

nature.com

Job Opportunity at University of Leeds: Lecturer in Neuroscience

Salary: Grade 8 (£51,753 – £59,966 p.a.)This role will be based on the university campus, with scope for it to be undertaken in a hybrid manner. We are also open to discussing flexible working arrange...

jobs.leeds.ac.uk

Scientists Unveil ‘Long Lost’ Map for Smell

nytimes.com

Job Opportunity at University of Leeds: Lecturer in Neuroscience

Salary: Grade 8 (£51,753 – £59,966 p.a.)This role will be based on the university campus, with scope for it to be undertaken in a hybrid manner. We are also open to discussing flexible working arrange...

jobs.leeds.ac.uk

Metabolic regulation of neural circuits controlling cognition and metabolism

Project opportunity - Metabolic regulation of neural circuits controlling cognition and metabolism at the University of Leeds

phd.leeds.ac.uk

Isotonic and minimally invasive optical clearing media for live cell imaging ex vivo and in vivo - Nature Methods

SeeDB-Live is a tissue-clearing approach for live samples such as tissue slices or the in vivo brain. It improves image quality while having minimal effects on electrophysiological properties of neuro...

nature.com

Don’t deprioritize curiosity-driven research

Around the world, governments are demanding that research funding follow broader political priorities. They should be careful what they wish for.

nature.com

Leeds Doctoral Scholarships 2026

Project opportunity - Leeds Doctoral Scholarships 2026 at the University of Leeds

phd.leeds.ac.uk

British Neuroscience Association’s response to the Government strategy on animal testing and new alternative methods

bna.org.uk

Integration of hunger and hormonal state gates infant-directed aggression - Nature

Combined behavioural, circuit-level and cellular approaches are used to demonstrate how hypothalamic neurons integrate hunger and oestrous state to drive a switch in how female mice interact with pups...

nature.com

Amplification of Olfactory Transduction Currents Implements Sparse Stimulus Encoding

Sensory systems must perform the dual and opposing tasks of being sensitive to weak stimuli while also maintaining information content in dense and variable sensory landscapes. This occurs in the olfa...

jneurosci.org

Recalibrating Olfactory Neuroscience to the Range of Naturally Occurring Odor Concentrations

Sensory systems enable organisms to detect and respond to environmental signals relevant for their survival and reproduction. A crucial aspect of any sensory signal is its intensity; understanding how...

jneurosci.org

Autistic behavior is a common outcome of biallelic disruption of PDZD8 in humans and mice

rdcu.be

Axially decoupled photo-stimulation and two photon readout (ADePT) for mapping functional connectivity of neural circuits

All optical physiology in vivo provides a conduit for investigating the function of neural circuits in 3-D. Here, we report a new strategy for flexible, axially-decoupled photo-stimulation and two pho...

doi.org

A hypothalamic circuit underlying the dynamic control of social homeostasis

Nature - New data on brain-wide circuits centred around two interconnected hypothalamic neuron populations provide significant mechanistic insights into the emergence of social need during social...

rdcu.be