Joseph D. Zak

@josephdzak.bsky.social

Neurobiologist and Assistant Professor at the University of Illinois Chicago studying sensory cells and neural circuits. #Neuroscience and #Olfaction. https://www.zak-lab.org

Tremendously excited to announce that I will be joining @rockefeller.edu as an Assistant Professor and Head of Lab starting in January 2027! My group will be broadly focused on theoretical neuroscience, and mathematical problems in neural computation in the large.

Rockefeller campus image from https://commons.wikimedia.org/wiki/File:Rockefeller_University_Campus_aerial_2.jpg, licensed under the Creative Commons Attribution-Share Alike 2.5 Generic license.

Our latest work is available at @sfnjournals.bsky.social. This project was conceived of and completed by Kai Clane Belonio, an amazing postbac student who worked with us for the past two years. We learned that stress influences olfactory experience and activates microglia in the piriform cortex.

SfN Journals@sfnjournals.bsky.social · 4mo ago

#eNeuro: People who experience depression after long-term stress are more sensitive to unpleasant smells. Belonio et al. used mice to explore the mechanism for this change in the sense of smell. https://doi.org/10.1523/ENEURO.0330-25.2026

#Wolbachia has puzzled scientists with its power to rewire insect reproduction. What if I tell you that we found one of the keys Wolbachia use to rewire its host AND a small molecule inhibitor uses this key to mimic what this microbe has mastered for millions of years. www.cell.com/cell-reports...

Beyond Wolbachia—Can a small molecule control insect reproduction?

Kaur et al. demonstrate reduced histone acetylation as a key mechanism underpinning Wolbachia’s paternal-effect embryonic lethality trait in Drosophila melanogaster. Recapitulation of this trait by in...

cell.com

Proud to share Kai Clane Belonio’s latest work in our lab. Kai showed that induced-depression decreases behavioral tolerance of aversive odorants as well as increases in neuroinflammation in sensory affective areas. Also contributing are @nervenkidd.bsky.social and Eyerusalem Haile.

bioRxiv Neuroscience@biorxiv-neursci.bsky.social · 12mo ago

Neuroinflammation in Olfactory Circuits Underlies Odor Hypersensitivity in a Rodent Model of Depression https://www.biorxiv.org/content/10.1101/2025.08.14.670114v1