#FOXP3 deep intronic variant underlying #IPEX. New report from Pierre Gaufryau, Marie-Claude Stolzenberg, Jérémie Rosain @jrosain.bsky.social et al. @hopitalnecker.bsky.social @institutimagine.bsky.social: rupress.org/jhi/article/... #Atopy #Diagnostics #Autoimmunity #InbornErrorsOfImmunity

🩸 Violent immune reactions (HLH) often hide blood cancer. Biopsies are risky, but a new 2-step blood test (cytokine ratio & score) from Hermine's team at Institut Imagine quickly identifies underlying lymphomas—meaning fewer invasive procedures and faster treatment. 🔗 doi.org/10.1002/ajh....

1/ We are thrilled to share our first @cellcellpress.bsky.social paper with the ATLAS team studying the role of antibodies, emphasizing autoantibodies in cancer (authors.elsevier.com/a/1nUSAL7PXy...).

🔬 How do ADPKD cysts form? A JCI study by @hkd-l.bsky.social at Institut Imagine & Frank Bienaimé's group @inem-necker.bsky.social shows: without polycystin-1, the tubule sleeve gets softer, not stiffer. This loosening lets the tube expand. A new therapeutic target! 👏 📄 jci.org/articles/vie...

Why do some ‘super avoiders’ never develop cancer? Team ATLAS has launched its global effort to find out, supported by the Breast Cancer Research Foundation, the Susan Wojcicki Foundation, the Torrey Coast Foundation and @cancerresearchuk.org. ➡️ www.cancergrandchallenges.org/news/backing...

After 10 fantastic years at the @mrc-mbu.bsky.social, @cam.ac.uk, it is time for our lab to move to France!! I am delighted to announce that we will begin a new adventure at the @institutimagine.bsky.social in Paris in September 2026!!

🧠 What if Alzheimer's isn't just about neurons? A new Nature Neuroscience study from Michela Deleidi's team at Imagine shows stressed mitochondria cause microglia (brain immune cells) to age prematurely, disrupting neural connections. 📄 lnkd.in/gCg5qdRb

ADAR1 loss-of-function variants altering RNA editing define a new #interferon-dependent #psoriasis subtype. New study from Florence Assan, Hervé Bachelez @institutimagine.bsky.social and colleagues: rupress.org/jem/article/... #HumanDiseaseGenetics

Kicking off today's MAGIC meeting on "Development & Mechanics"! 🧬 First up: Audrey Desgrange (Institut Imagine) on the "Biomechanics of heart development." We're exploring how physical forces actively shape our most vital organ. ❤️🔬 🧵👇 #DevBio #Biomechanics #HeartResearch

📢 Happening Now: Weekly Monday Seminar! We are thrilled to welcome Prof. Aleixo Muise (University of Toronto & @sickkids.bsky.social sky.social) to Institut Imagine today. He is currently presenting: "Novel insights into Monogenic Intestinal Disease." #Genetics #Immunology #Research

🏅 Notre directrice générale, la Pr Bana Jabri, figure dans le palmarès 2026 du TIME France Health, parmi « Les 20 personnalités françaises qui font la santé » !

Congratulations to LS1 grantees @hecklab.bsky.social and Annarita Miccio at @institutimagine.bsky.social , for being awarded ERC POC grants! :)

European Research Council (ERC)@erc.europa.eu · last mo.

The round 1 results of the 2026 ERC Proof of Concept Grant call are out! 🎉 182 researchers receive a total of €27.3 million to explore the commercial and societal potential of their ERC-funded findings. Read more 👉 buff.ly/K8GXgbs #ERCPoC #FrontierResearch @scienceinnovation.ec.europa.eu

We're live from the Future of Genetic Medicine Symposium today at Institut Imagine! 🧬 We are incredibly delighted to partner with @genethonfr.bsky.social & the Broad Institute's Center of Genetic Surgery for this event.

🔬 Kicking off our weekly MAGIC meeting! Our own Alice Lepelley is on stage sharing novel insights into type I IFN neuroinflammation driven by PTPN1 mutations in humans. 🧠🧬 #Neuroinflammation #Genetics #Interferon

🧬 Happening now: Prof. Yenan Bryceson (Karolinska Institutet) is presenting today's Monday Seminar at Imagine. He's discussing the "Regulation of flexibility in T cell signaling," exploring the biology of cytotoxic T cells to better understand primary immunodeficiencies & develop cancer therapies.

Studying cancer avoidance isn’t straightforward. It means finding individuals who don’t develop cancer, and analysing them at scale. That level of research needs global collaboration, and Cancer Grand Challenges makes it possible. Read about this work ➡️ www.technologynetworks.com/cancer-resea...

Live from Institut Imagine for the MAGIC seminar! 🧬 Today, we're exploring major advances in therapeutic antibodies and immunology with 4 experts. Follow this thread for key takeaways from the presentations. ⬇️

STAT2 R148 variant: A 16th-century founder mutation and clinical response to high-dose JAK inhibitor therapy. New study from Nima Parvaneh (Tehran University of Medical Sciences), Jacinta Bustamante @institutimagine.bsky.social and colleagues: rupress.org/jhi/article/... #Autoinflammation #IEIs

Wrapping up Monday with some fantastic science! 👏 Earlier today, we had the pleasure of hosting Dr. Enzo Poirier (Institut Curie) for our #MondaySeminar. Huge thanks to him for sharing his work on engineering immunotherapies by harnessing the conservation of immunity. 🧬

🧠 What makes the human brain uniquely... human? That's the question at the heart of a study just published in @nature.com by Denis Jabaudon, Esther Klingler, and their teams. 📄 Javed, Gómez et al., Nature (2026) — DOI: lnkd.in/eF_mH72U

🔴 LIVE: Our weekly MAGIC seminar is starting! First up: Kesia Dethelot Delag on bridging the gap between clinical sites. She is discussing uncertainty quantification & federated learning strategies to improve patient stratification and rare disease diagnosis while keeping data secure. 🧬📊

Why are some people immune to cancer? Learn more about team ATLAS, led by Paul Bastard, @institutimagine.bsky.social👉 www.youtube.com/watch?v=dFJA... ATLAS is funded by @cancerresearchuk.org and Torrey Coast Foundation through Cancer Grand Challenges.

Happening now at Institut Imagine! 🔬 Prof. Luis Barreiro (UChicago) is taking the stage for today's Monday Seminar to discuss why individuals and populations differ in their susceptibility to infections and immune-related diseases. 🦠🧬

Ribosomal RNA processing impairments in a B cell immunodeficient patient with WDR75 variants. New study from Nidia Moreno-Corona, Sven Kracker @institutimagine.bsky.social and colleagues: rupress.org/jhi/article/... #RareDisease #ClinicalPhenotypes #InbornErrorsOfImmunity

1/ We are thrilled to share our collaborative study of B cells producing auto-Abs neutralizing type I IFNs in @cellpress.bsky.social (www.cell.com/cell/abstrac... ).

Affinity-matured B cell responses neutralizing type-I interferons underlie severe viral infections

By integrating functional and structural approaches with AI-based analysis of autoantibodies against type-I IFNs, these neutralizing autoantibodies—linked to severe viral diseases in humans—are shown ...

cell.com

C’est avec une profonde tristesse que l’Institut Imagine annonce le décès du Professeur Claude Griscelli, son président fondateur, pédiatre, immunologiste et pionnier de la recherche sur les maladies génétiques. www.linkedin.com/feed/update/...

#institutimagine #claudegriscelli #maladiesgénétiques #recherchemédicale #pédiatrie | Institut Imagine

C’est avec une profonde tristesse que l’Institut Imagine annonce le décès du Professeur Claude Griscelli, son président fondateur, pédiatre, immunologiste et pionnier de la recherche sur les maladies ...

linkedin.com

Nidia Moreno-Corona, Sven Kracker et al. describe WDR75 variants in a patient with B cell immunodeficiency and #autism. Their findings suggest that altered #ribosome biogenesis may contribute to this rare presentation. rupress.org/jhi/article/... #RareDisease @institutimagine.bsky.social

🔬 What if we could spot preeclampsia before symptoms appear? Research by @manusingh.bsky.social in Genome Biology shows ancient viral remnants in our DNA act as "molecular switches" for placental development—leaving traces in maternal blood when they malfunction. 🎥 www.linkedin.com/feed/update/...

#research #preeclampsia #genomics #medicalresearch #institutimagine | Institut Imagine

🔬 What if we could detect preeclampsia before the first symptoms even appear? That is the promise of new research led by Dr. Manvendra Singh, group leader at INEM - Institut Necker Enfants Malades, i...

linkedin.com

Pourquoi certains ne développent jamais de cancer ? Sur @rfi.fr, le Dr Bastard présente ATLAS, un projet financé à hauteur de 25 M$ par @cancergrand.bsky.social pour identifier nos anticorps protecteurs. 🎧 : www.rfi.fr/fr/vid%C3%A9...

Si vous êtes sur Paris, passez voir le stand de l’institut @institutimagine.bsky.social place de la Concorde dans le cadre de l’exposition «vivre ensemble» de la fondation GoodPlanet! J’y suis et demain après-midi pour vous expliquer nos projets au @hkd-l.bsky.social #cilia #ciliopathies