Our laboratory is looking for a PhD student in Functional Genomics (fully funded position). Expected starting date: Oct 2026 More info here: www.igbmc.fr/en/igbmc/lif... Please share 📨

IGBMC@igbmc.bsky.social · 4w ago

PhD position in Functional Genomics, in Raphaël Pantier's lab: Interplay between transcription factors and genome architecture in embryonic stem cells more info : amethis3.unistra.fr/amethis-clie...

Les nouveaux critères d'éligibilité de l' #ANR 2027, c'est juste pour nous dégoûter et nous faire chier encore un peu plus pour restreindre le nombre de dépôts parce que franchement, je ne vois vraiment rien de vertueux dans cette nouvelle usine à gaz #ESR anr.fr/fr/detail/ca...

Consulter

anr.fr

Instrument–Software Synergy in Proteomics: Systematic Evaluation across Mass Spectrometry Platforms, Search Engines, and Rescoring Methods pubs.acs.org/doi/10.... --- #proteomics #prot-paper

Our first HUPO Single Cell Initiative benchmarking study is out! 🎉 7 labs, 2 continents, 2 instrument platforms, 6 DIA tools - working toward reproducible, comparable single-cell proteomics. Code + processed data available now, raw data coming soon.

Defining Quality Control Standards for Single-Cell Proteomics by Inter-Laboratory Benchmarking

Single-cell proteomics can quantify thousands of proteins from individual mammalian cells, yet the absence of community-wide quality control limits biological interpretability. Here, the HUPO Single C...

biorxiv.org

Defining Quality Control Standards for Single-Cell Proteomics by Inter-Laboratory Benchmarking www.biorxiv.org/cont... --- #proteomics #prot-preprint

Excited to share our preprint introducing ASHI: the Atlas of SLiM-mediated Human protein-protein Interactions. By screening 800+ domains against the human intrinsically disordered regions, we map 20,000 SLiM-mediated interactions. Many thanks to everyone involved! www.biorxiv.org/content/10.6...

An Atlas of Short Linear Motif-Mediated Human Protein-Protein Interactions

Short linear motifs (SLiMs) within intrinsically disordered protein regions mediate transient interactions crucial for cell physiology. However, the global interaction landscape of human SLiMs remains...

biorxiv.org

An Atlas of Short Linear Motif-Mediated Human Protein-Protein Interactions https://www.biorxiv.org/content/10.64898/2026.07.03.735260v1

An Atlas of Short Linear Motif-Mediated Human Protein-Protein Interactions www.biorxiv.org/cont... --- #proteomics #prot-preprint

#Communiqué 🗞️ Thierry Dauxois, Pdg du CNRS, nomme Sandrine Sagan directrice générale déléguée à la science du CNRS, à compter du 1er août 2026. Actuelle directrice de CNRS chimie, elle succèdera à Alain Schuhl dont le mandat s’achève fin juillet. 👉 www.cnrs.fr/fr/presse/sa...

The Thermo Fisher situation keeps getting worse. We've now collected 450+ problematic images presented as verification data in TF's antibody catalog. This includes: 🖌️ Dozens more images with duplications or painting 🖨️ Hundreds of blots that all share the same background (behold slideshow below)

Excited that the final version of our experimental assessment of AI protein interaction predictions is out: www.nature.com/articles/s41... Brief summary below:

Experimental assessment of AI-based interactome mapping - Nature Communications

AlphaFold’s success in protein structure predictions has led to similar attempts to predict interactomes. Here, the authors demonstrate that AI-based screens are very limited in discovering truly nove...

nature.com

This was a very long and yet intellectually very stimulating and rewarding collaboration.

Luke Lambourne@lukelambourne.bsky.social · 3mo ago

There's a lot more in the paper that I've skipped over. The YeRI map is available to browse here: yeast.interactome-atlas.org. Thanks to everyone in this big team for all their work! Alice, Yang, Anu, Kerry, Tong, Javier, @mcalderwood.bsky.social, Dave, @interactome.bsky.social, JC, Marc and more

😱

Johan Duchêne@johanduchene.bsky.social · 3mo ago

@sholtodavid.bsky.social Have you seen this WB from ThermoFisher? Still anti-p53 antibody, but another clone (MA-12648 instead MA5-12557). It also looks like that the band in lane 3 was rotated and reused in lane 4. Moreover, it seems that same band was used for the 2 different clones.

@sholtodavid.bsky.social Have you seen this WB from ThermoFisher? Still anti-p53 antibody, but another clone (MA-12648 instead MA5-12557). It also looks like that the band in lane 3 was rotated and reused in lane 4. Moreover, it seems that same band was used for the 2 different clones.

Major new work by the #TransCODE Consortium out today in @nature.com. Read all about our efforts to shed light onto the forgotten areas of the human proteome. #Microproteins #Peptideins #DarkProteome This was a huge global collaboration, in part funded via #NIH www.nature.com/articles/s41... 1/

Expanding the human proteome with microproteins and peptideins - Nature

A large-scale proteomics analysis of the dark proteome by the TransCODE Consortium reveals many translated non-canonical open reading frames to encode microproteins and peptideins.

nature.com

In collaboration with the TransCODE consortium, EMBL-EBI scientists have found over 1,700 new proteins in the ‘dark proteome,’ a region of the human genome once thought to be noncoding. These new proteins could have implications for human diseases, including cancer. tinyurl.com/yc4t6s3s

#ESR #CNRS #veilleESR Vu sur un autre réseau, je reposte 💯 Message clair, net et précis de Carine Tisné, sur la baisse du budget du CNRS et la situation de la recherche française qui ne cesse de se dégrader depuis 20 ans.

Just finished reading this lovely paper by @zbobo2.bsky.social , @teamgogl.bsky.social , Gilles Travé, and collaborators, describing a new technique for quantifying transcription factor:DNA binding without protein purification. A short reader's summary follows.

1) The Herzik lab is excited to announce our newest preprint in collaboration with the Grotjahn lab! We have developed a surfactant cocktail that seeks to overcome one of the more nefarious problems in #cryoEM, Air-water interface (AWI)-induced damage and preferred orientation (PO).

Ever wondered how a eukaryotic transcription factor finds its specific DNA motif in the vast genome? In this preprint, we directly measured the dynamics of this search process in living cells, revealing a cooperative mechanism mediated by disordered regions. 1/10 doi.org/10.64898/202...

We have started a project trying to predic the interactions/structures of all yeast protein pairs using an AlphaFold pooling approach. We are making the current dataset open and we welcome collaborations. www.evocellnet.com/2026/03/mapp...

Mapping the yeast atructural interactome with AlphaFold3: an open call for collaboration

We are excited to announce the early-stage release of our S. cerevisiae  structural interactome mapping project. Using AlphaFold3 (AF3), w...

evocellnet.com

A big thank you to @intact-ebi.bsky.social for the great collaboration integrating our high-throughput binding affinity (Kd) measurements into their database! Check out the kind of data we can generate using the Holdup assay — and there’s much more to come!

IntAct@intact-ebi.bsky.social · 6mo ago

🔬✨ New in 𝐈𝐧𝐭𝐀𝐜𝐭! Quantitative fragmentomics data (Nat Commun 2022) now integrated into IntAct - bringing high-quality, quantitative protein-protein interactions to the database.

The FMI cryo-EM team is looking for a new team member. Join us in Basel!

FMI science@fmiscience.bsky.social · 6mo ago

🚀 We’re hiring! The Structural Biology Platform is seeking a Project Leader to advance cryo-electron tomography and expand capabilities at the FMI. Join a vibrant research community at the interface of structural biology, cell biology & disease mechanisms. Apply at: www.fmi.ch/education-ca...

Et le sourire ! Parce que évidemment il faut être contente et reconnaissante d'être là

Dr. Hab Sophie Sacquin-Mora@sacquin-mo.eurosky.social · 6mo ago

Et donc, si j'en crois l'illu générée pas IA de l'ENS, on peut faire de la science en étant une femme, mais le brushing et le port du rouge à lèvre restent obligatoires (exception faite de la schtroumpfette, qui a le droit à un chignon)

Après des années de chroniques climatosceptiques, l'Actualité Chimique nous offre une couverture full IAgen qui fera saigner les yeux des collègues bossant sur les acides nucléiques. Une publication décidément à la pointe sur les enjeux de société...

Many congrats @teamgogl.bsky.social @camilleberthelot.bsky.social for the 2025 Impulse and @abdourachidthiam.bsky.social for the 2025 Liliane Bettencourt Prize for Life Sciences www.fondationbs.org/en/our-commu...

Our community

Meet the award-winners and projects leaders supported by the Foundation, full_html

fondationbs.org

Why IDPs Are Poor Candidates for Homotypic LLPS 🧵👇A thread

New preprint! We measured temperature- and pH-induced aggregation for over 18,000 natural and de novo designed protein domains!

Our new special collection "Protein-Nucleic Acid Interactions: From Origins to Design (2025)" is now published in Current Opinion in Structural Biology. I'm excited to have both co-edited it with Shandar Ahmad and contributed a review! www.sciencedirect.com/special-issu...

The IGBMC is recruiting a new Computational Biology Group Leader through the ENACT AI Chair for Scientific Discoveries, covering cancer, developmental, and structural biology. Join one of Europe’s leading life science centers! cluster-ia-enact.ai/appels-a-pro... Deadline: Jan 7, 2026