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Jake Choby

@jakechoby.bsky.social

Assistant Professor, University of North Carolina Antibiotic heteroresistance in Enterobacterales chobylab.org

6 Posts403 Follower147 Folgt
Erin Green@erinrgreen.bsky.social · 3mo ago

Excited to share the final part of my postdoc work, where we investigate the impact of antimicrobial treatment on susceptibility to hospital-acquired Acinetobacter baumannii pneumonia. Thanks to our amazing group of collaborators for their contributions to this study! www.pnas.org/doi/10.1073/...

The intestinal microbiota impacts nutritional immunity and resistance to Acinetobacter baumannii pneumonia | PNAS

Broad-spectrum antibiotics are frequently administered to intensive care unit patients as part of empiric care. This treatment has been associated ...

pnas.org

David Weiss@dweisslab.bsky.social · 5mo ago

Bacteria in our BRAINS??! We observed translocation of bacteria from the gut to the brain via the vagus nerve. This occurred after high fat diet, or without dietary changes in mouse models of Alzheimer’s, Parkinson’s, and autism. journals.plos.org/plosbiology/...

Translocation of bacteria from the gut to the brain in mice

Recent studies link gut dysbiosis to neurological disease, but the underlying mechanisms remain unclear. This study shows that a high-fat diet increases gut permeability and enables bacterial transloc...

journals.plos.org

AMR-kleb/staph@s-rowe-conlon.bsky.social · 8mo ago

Thrilled to share our latest paper on antibiotic treatment failure of Klebsiella pneumoniae liver abscesses www.pnas.org/doi/full/10.... @drwalkermsbanta.bsky.social

Antibiotics accumulate in Klebsiella pneumoniae liver abscesses but fail to eliminate antibiotic-tolerant populations | PNAS

Liver abscesses caused by hypervirulent Klebsiella pneumoniae (hvKp) can lead to severe metastatic complications, with mortality rates ranging from...

pnas.org

Conlon Lab@bconlon.bsky.social · 10mo ago

Delighted to share our latest paper - A host-directed adjuvant sensitizes intracellular bacterial persisters to antibiotics. Excellently led by Dr. Kuan-Yi Lu. We think it's a great proof-of-concept that altering immune cell behavior can make antibiotics work better www.nature.com/articles/s41...

A host-directed adjuvant sensitizes intracellular bacterial persisters to antibiotics - Nature Microbiology

The authors developed a screen to find compounds that modulate intracellular Staphylococcus aureus metabolism and discovered KL1, which sensitizes persisters to antibiotics by reversing host-induced tolerance.

nature.com

Lauren Palmer@laurenpalmer.bsky.social · last yr.

Super excited to share our paper online 🚨today🚨 in Cell Host & Microbe‬! Xiaomei Ren @xiaomeiren.bsky.social and Mason Clark @rmasonclark.bsky.social‬ co-led discovery of ecological factors for Acinetobacter baumannii carriage in the gut, a reservoir for pathogen spread. 🎉 tinyurl.com/443kfefk

Cell Host & Microbe@cp-cellhostmicrobe.bsky.social · last yr.

Amino acid competition shapes A. baumannii gut carriage Acinetobacter baumannii uses ornithine to compete w/ microbiota & persist in gut. Amino acid supplementation & differences in diet promote A. baumannii gut colonization in mice & humans @laurenpalmer.bsky.social‬ www.cell.com/cell-host-mi...

Jake Choby@jakechoby.bsky.social · last yr.

Excited to share the work with @dweisslab.bsky.social‬ and great collaborators on how gene amplification generates dynamic heteroresistance to new beta-lactams, like cefiderocol. We hope drug developers will consider heteroresistance during antibiotic development rdcu.be/euijW

Copy number flexibility facilitates heteroresistance to increasing antibiotic pressure and threatens the beta-lactam pipeline

Nature Communications - Choby et al. show that dynamic increases in the copy number of preexisting β-lactamase genes in heteroresistance enables resistance of continua of cellular...

rdcu.be

Jake Choby@jakechoby.bsky.social · 2y ago

pleased to share our (with @dweisslab.bsky.social) News & Views perspective on this exciting paper nam11.safelinks.protection.outlook.com?url=https%3A...

Zinc-dependent β-lactam resistance at a cost

Nature Microbiology - Chemical genomics reveals the fitness cost of bacterial metallo-β-lactamase in zinc-deplete environments, with implications for treatment options.

nam11.safelinks.protection.outlook.com

Nature Microbiology@natmicrobiol.nature.com · 2y ago

Out now: Exploiting the fitness cost of metallo-β-lactamase expression can overcome antibiotic resistance in bacterial pathogens by Eric Brown, Jon Stokes & co #microsky www.nature.com/articles/s41...