Excited to share that our team is joining ASAP CRN @asapresearch.parkinsonsroadmap.org! We look forward to collaborating with scientists globally to catalyze breakthroughs in Parkinson’s & accelerate discoveries that lead to new treatments. Explore more: asapcrn.org #ParkinsonsDisease

Are you interested in achieving efficient silencing of transposable elements using CRISPRi? 🧬 🧫 Go ahead and have a look at this STAR protocols where Adami et al. share all the tips & tricks they use in the Jakobsson lab. @anitaada.bsky.social @raquelgarza.bsky.social @jakobssonlab.bsky.social

Protocol for efficient CRISPRi-mediated silencing of retrotransposons in human pluripotent stem cells

Here, we present a workflow for transcriptional silencing of transposable elements (TEs) in human induced pluripotent stem cells (hiPSCs). We describe steps for designing guide RNAs (gRNAs) to target ...

cell.com

CRN Teams Cragg & Jakobsson's new #preprint maps the cell-type–specific transcriptional landscape of the parkinsonian striatum in mouse models and human Parkinson's stages, revealing widespread gene expression changes and resilient neuron subtypes amid progressive dopamine loss 🧪 🔗 bit.ly/4ju4MmS

Have a look at two of the latest outputs from CRN Team Jakobsson, examples of true team effort and collaboration 🧠 💫 We are grateful to @asapresearch.parkinsonsroadmap.org for making this research possible! @jakobssonlab.bsky.social @kirkebylab.bsky.social @mollygale.bsky.social #RogerBarkerLab

Aligning Science Across Parkinson's@asapresearch.parkinsonsroadmap.org · 10mo ago

New #publication and #preprint from @jakobssonasap.bsky.social! ⬅️ L1 retrotransposons in stem cells & organoids link L1s to CNS development 🔗 bit.ly/3XyLvGz ➡️ Transposable elements activate in the #Parkinsons brain, tied to interferon responses & a new pathological process 🔗 bit.ly/3LKC5Fo

Agnete Kirkeby’s 2025 Edinburgh Parkinson’s Lecture is available online: youtu.be/EtuRHdPX4rc?... She delivered a masterclass on stem cell therapies for #Parkinsons. A PwP told me : “I was expecting not to understand much, but I understood everything!” @kirkebylab.bsky.social @parkinsons.org.uk

Always a joy to join #EMBOMobileGenome -A week full of cool nature’s quirks and science along the friendliest crowd 🧬 Happy to have shared our work on ERVs in human brain evolution (talk by @jakobssonlab.bsky.social) and Parkinson’s disease (poster by yours truly) 🧠 #ASAP @jakobssonasap.bsky.social

📣 New preprint from the Jakobsson lab! We describe a detailed protocol to inhibit the expression of transposable elements in human pluripotent stem cells, developed thanks to @asapresearch.parkinsonsroadmap.org funding. Special shoutout to @anitaada.bsky.social! www.biorxiv.org/content/10.1...

A framework for efficient CRISPRi-mediated silencing of retrotransposons in human pluripotent stem cells

This protocol describes the workflow for transcriptional silencing of transposable elements (TEs) in human induced pluripotent stem cells (hiPSCs). The protocol illustrates how to design gRNAs to targ...

biorxiv.org

@raquelgarza.bsky.social from the Jakobsson Lab presented our recent work on single-cell omics (transcriptomics+ proteomics) within our ASAP project at the SciLifeLab Lund day. This work is being done in collaboration with #BioMS and @scilifelab.se. We are looking forward to the discoveries ahead 🌟

Have a look at the new preprint from Team Cragg! We are very happy of having contributed to this great work as a collaboration within the ASAP-CRN network 🧠🔬 @craggasap.bsky.social @asapresearch.parkinsonsroadmap.org

ASAP CRN Team Cragg@craggasap.bsky.social · last yr.

📣 New preprint alert 📣 A new collaborative study from @meletis.bsky.social and @jakobssonasap.bsky.social on mapping the molecular changes in the mouse and human striatum in #Parkinsons! Congratulations to Marta Graziano and Ioannis Mantas for spearheading this fantastic work! #OpenScience

🚨 Have a look at our new preprint: www.biorxiv.org/content/10.1... A highly collaborative effort where we show that transposable elements are directly linked to a cell-type and region specific inflammatory state in Parkinson’s Disease. @asapresearch.parkinsonsroadmap.org

Activation of transposable elements is linked to a region- and cell-type-specific interferon response in Parkinson's disease

Parkinson's disease (PD) is a common age-related neurodegenerative disorder involving a neuroinflammatory response, the cause of which remains unclear. Transposable elements (TE) have been linked to i...

biorxiv.org

Raquel Garza@raquelgarza.bsky.social · last yr.

💥 New preprint! 💥 We show that transposons are directly linked to a cell-type and region specific inflammatory state in Parkinson’s Disease 🧠🦠 What a team @jakobssonasap.bsky.social! Funded by @asapresearch.parkinsonsroadmap.org #Parkinsons #Neuroinflammation #TEworldwide #singlecell #TEs

🧬 🧠A new Cell Genomics study by researchers at @lunduniversity.bsky.social (@jakobssonlab.bsky.social & @jakobssonasap.bsky.social) shows the non-coding genome is active in early brain development & may be relevant for understanding brain disease. Read more: www.stemcellcenter.lu.se/article/why-...

Why repetitive DNA matters for human brain evolution and disease

Lund University. DNA carries the complete set of instructions an organism needs to develop and survive, but only about 1.5% of it consists of protein-coding genes that determine traits such as eye col...

stemcellcenter.lu.se

Team Jakobsson gathered in southern Sweden for a few inspiring days discussing PD, transposable elements and future plans. We even squeezed in a hike and enjoyed some beautiful views ☀️🌊 @jakobssonlab.bsky.social @kirkebylab.bsky.social @mollygale.bsky.social @asapresearch.parkinsonsroadmap.org

These past 2 months as a visiting scholar at KU Leuven flew by! It has been so enriching to work side by side with #TeamVoet on @jakobssonasap.bsky.social research into Transposable Elements & Parkinson’s Disease 🧠🧬 Excited for what’s next! #ParkinsonsDisease #MJFF #ASAP #CRN #TransposableElements

Last week, some of us from Team Jakobsson had a great time in Arizona at the 2025 CRN Collaborative Meeting! Plenty of insightful talks and networking. Shoutout to @kirkebylab.bsky.social for a fantastic talk on PSC-based therapies and models of PD 🌟🧬🏜️ #CRNPhoenix2025 @asapresearch.bsky.social

Popcorn worthy research at #CRNPhoenix2025 with @jakobssonasap.bsky.social 🍿 #ParkinsonsDisease #PD #TEsky

🧠🔬 Great meeting last Friday in Copenhagen between the Kirkeby and Jakobsson labs — exciting experiments coming up to investigate transposons in PD in vitro models! @asapresearch.bsky.social @kirkebylab.bsky.social @jakobssonlab.bsky.social

🚨 New pre-print from Team Jakobsson! LINE-1 retrotransposons regulate the exit of human pluripotency and early brain development. This work was led by @anitaada.bsky.social, @raquelgarza.bsky.social and @jakobssonlab.bsky.social from the Jakobsson Lab. www.biorxiv.org/content/10.1...

LINE-1 retrotransposons regulate the exit of human pluripotency and early brain development

Long interspersed nuclear element 1 (L1) retrotransposons represent a vast source of divergent genetic information. However, mechanistic analysis of whether and how L1s contribute to human development...

biorxiv.org

🌟🧠🧬 Exciting meetup in Cambridge with the Barker, Jones and Jakobsson labs! Great discussions, fresh ideas, and plenty of plans for the next steps. @asapresearch.bsky.social @jakobssonlab.bsky.social

We're thrilled to announce that our project has been funded by @asapresearch.bsky.social in partnership with the Michael J. Fox Foundation! 🚀 Excited to continue exploring the role of transposable elements in Parkinson’s disease. Learn more here: www.lunduniversity.lu.se/article/52-m...