Raquel Garza
@raquelgarza.bsky.social
Researcher 🧬👩💻 (she/her) Here for transposons, bioinformatics, and brains.
Major career news: I’ve been selected as a CRN Discovery Fellow by @asapresearch.parkinsonsroadmap.org! 🚀 The fellowship funds independently led, collaborative projects in #ParkinsonsDisease, meaning I get the opportunity to continue researching the role of #TransposableElements in #ageing and PD!
Always a joy to join #EMBOMobileGenome -A week full of cool nature’s quirks and science along the friendliest crowd 🧬 Happy to have shared our work on ERVs in human brain evolution (talk by @jakobssonlab.bsky.social) and Parkinson’s disease (poster by yours truly) 🧠 #ASAP @jakobssonasap.bsky.social
#EMBOMobileGenome Session 2 on transposon regulation 🧬 ➡️'Epigenetic control of transcribed retroelements by the HUSH complex and associated factors' presented by Christopher Douse (Lund University, Sweden) We love a good Q&A session as well! 🙋🏼 @chdouse.bsky.social @lundstem.bsky.social @embl.org
Had an absolute blast presenting my “Last Minute Breakthrough talk” at #EMBOmobilegenome today! 🔥 What an incredible crowd, the energy in the room was unreal. Huge thanks to the organizers for selecting me and to everyone who came, asked questions, and made it such a fun session! 🙌
@raquelgarza.bsky.social from the Jakobsson Lab presented our recent work on single-cell omics (transcriptomics+ proteomics) within our ASAP project at the SciLifeLab Lund day. This work is being done in collaboration with #BioMS and @scilifelab.se. We are looking forward to the discoveries ahead 🌟
Thrilled to share our story in its final form! nature.com/articles/s41... 💥 After ~10 years, we show that BMAL1 represses transposons via chromatin regulation in embryonic stem cells—rather than circadian rhythms as in adult tissues.
nature.com
💥 New preprint! 💥 We show that transposons are directly linked to a cell-type and region specific inflammatory state in Parkinson’s Disease 🧠🦠 What a team @jakobssonasap.bsky.social! Funded by @asapresearch.parkinsonsroadmap.org #Parkinsons #Neuroinflammation #TEworldwide #singlecell #TEs
Cheers @anitaada.bsky.social for some more awesome science together 🍾🌟 Check out our latest work on L1 retrotransposons and their cis acting effect in early brain development 🧠 www.cell.com/cell-genomic...
Excited to share our latest work!! 🌟🌟 Thank you for all the amazing work and congratulations to @anitaada.bsky.social and all the coauthors! 🍾
Very happy to share our protocols paper for CELLO-seq. This will make single cell long read RNA-seq more accessible and provides analysis guidelines. We hope this helps the #transposon #TEsky community and folks working on #singleCell isoform and allelic #gene expression. doi.org/10.1038/s415...
Long-read RNA sequencing of transposable elements from single cells using CELLO-seq - Nature Protocols
Single-cell long-read RNA sequencing enables the high-fidelity mapping of single-cell expression data from highly sequence-similar transposable elements to unique genomic loci by correcting errors fro...
doi.org
⏰ Abstract deadline for 'The mobile genome' is 29 July! 👉 https://s.embl.org/mge25-01-bl Join us 4–7 Nov 2025 at EMBL Heidelberg (or online) to explore the impact of TEs across biology. 🧬🔍 ⭐🧑🏼🔬 24 talks + 15 flash talks from posters – don't miss out! #EMBOMobileGenome
These past 2 months as a visiting scholar at KU Leuven flew by! It has been so enriching to work side by side with #TeamVoet on @jakobssonasap.bsky.social research into Transposable Elements & Parkinson’s Disease 🧠🧬 Excited for what’s next! #ParkinsonsDisease #MJFF #ASAP #CRN #TransposableElements
Last week, some of us from Team Jakobsson had a great time in Arizona at the 2025 CRN Collaborative Meeting! Plenty of insightful talks and networking. Shoutout to @kirkebylab.bsky.social for a fantastic talk on PSC-based therapies and models of PD 🌟🧬🏜️ #CRNPhoenix2025 @asapresearch.bsky.social
Popcorn worthy research at #CRNPhoenix2025 with @jakobssonasap.bsky.social 🍿 #ParkinsonsDisease #PD #TEsky
Super happy to announce the latest work from my lab together with Hemali Phatnani @nygenome.org & NYGC ALS Consortium! We've combined ALS patient profiling (100s!), ML classifiers and matched bulk/single-cell data to dive into ALS Molecular Subtypes #NIHfundedResearch www.cell.com/cell-reports...
ALS molecular subtypes are a combination of cellular and pathological features learned by deep multiomics classifiers
O’Neill et al. present a deep exploration of molecular subtypes in ALS postmortem tissues from the NYGC ALS Consortium. Matched bulk and single-cell profiles demonstrate that ALS subtypes are a combin...
cell.com
In this paper, CRN Team @jacksonlab.bsky.social found that LINE-1 transposable elements contribute to the complexity of the transcriptome in human pluripotent stem cells by acting as alternative promoters for approximately 100 genes. Check out the full #preprint: shorturl.at/TJ9BK
Congrats @marliesoomen.bsky.social! 🧬🍾 Had been looking forward to see this paper since I heard of it in CSHL 🍂 Having it for JC next week 🤓
Marlies Oomen@marliesoomen.bsky.social · 2y agoVery excited to share our paper on Gene and Transposable Element expression in mammalian preimplantation development, online today! www.cell.com/cell/fulltex... A short thread to highlight some of our findings 🧵
🧠🔬 Great meeting last Friday in Copenhagen between the Kirkeby and Jakobsson labs — exciting experiments coming up to investigate transposons in PD in vitro models! @asapresearch.bsky.social @kirkebylab.bsky.social @jakobssonlab.bsky.social
We profiled the effects of our CRISPRi system targeting young L1 elements in human pluripotency & brain development. These elements deeply impact our transcriptome, but also have very distinct effects on their nearby genome. Check it out!! 🧬👾 #TEsky #CRISPR #L1 #development #epigenetics
ASAP Team Jakobsson@jakobssonasap.bsky.social · 2y ago🚨 New pre-print from Team Jakobsson! LINE-1 retrotransposons regulate the exit of human pluripotency and early brain development. This work was led by @anitaada.bsky.social, @raquelgarza.bsky.social and @jakobssonlab.bsky.social from the Jakobsson Lab. www.biorxiv.org/content/10.1...
CSH Asia is organising its first transposon meeting. Don't miss out on some great science and a fantastic trip. Abstract deadline fast approaching. www.csh-asia.org?content/2544
Tracking transposable element (TE) activity in genomics data can be a pain, but there are solutions! Our lab built TEtranscripts -- which we've updated to work for small RNAs (TEsmall), bulk RNA at the locus level (TElocal), and in single-cell data (TEsingle). Check it out! www.mghlab.org/software
💥🦊 So proud of being part of this team!
ASAP Team Jakobsson@jakobssonasap.bsky.social · 2y agoWe're thrilled to announce that our project has been funded by @asapresearch.bsky.social in partnership with the Michael J. Fox Foundation! 🚀 Excited to continue exploring the role of transposable elements in Parkinson’s disease. Learn more here: www.lunduniversity.lu.se/article/52-m...
🧬 🧠 Excited to see it printed! We bring key insights on the epigenetic regulation of SVAs, including SVA-XDP: a polymorphic SVA driving a rare neurodegenerative disorder @jakobssonlab.bsky.social @vivienhorvath.bsky.social #TEworldwide #Transposons #XDP #NSMB + the volume has the cutest cover 🦔
Today we are showing high school students how cool things we can do using #nanopore sequencing at the #unistemday at the Lund Stem Cell Center 🧬👩🔬🦠🧪
🐒 The Tale of Our Long Lost Tail Insertion of a short DNA sequence into a gene that controls tail development could explain tail loss in the common ancestor of apes. A mobile DNA sequence could explain tail loss in humans and apes 🏺🧪 www.nature.com/articles/d41...
