Looks like a nice resource: * Array genetic data for 80,638 Japanese children * 1,163 child health and developmental traits (e.g. food allergy, anthropometric, developmental) * Parental environmental exposures www.medrxiv.org/content/10.1...
James
@jameshow12.bsky.social
Psychology undergraduate at the University of Liverpool. Student Member of the British Psychological association. I will be posting my articles for Scientia News here.
If you missed the last ten years of behaviour genetics you can pretty much catch up on everything by reading all his blogposts.
Sasha Gusev@sashagusevposts.bsky.social · last yr.I wrote about how population stratification in genetic analyses led to a decade of false findings and almost certainly continues to bias emerging results. But we are starting to have statistical tools to sniff it out. A 🧵:
Diagnostic categories in mental health do not distinguish people or brains "Our results did not support the validity of existing diagnostic labels of ASD, ADHD, and OCD as distinct entities with respect to phenotype and cortical morphology." www.nature.com/articles/s41...
Examining overlap and homogeneity in ASD, ADHD, and OCD: a data-driven, diagnosis-agnostic approach - Translational Psychiatry
Translational Psychiatry - Examining overlap and homogeneity in ASD, ADHD, and OCD: a data-driven, diagnosis-agnostic approach
nature.com
Are there any good blogposts or commentaries on the 2025 depression gwas?
Thoughtful piece by Greg Gibson pushing strongly back on the "Heritable polygenic editing" article genomestake.substack.com/p/genome-edi...
Genome Editing and Eugenics
The one hundred and third Take:
genomestake.substack.com
RIP, David Lynch. Truly one of the great weirdoes in film and television history.
A Green New Deal makes sense if you’re in a recession, but a full employment economy needs a different approach to energy and prosperity. www.slowboring.com/p/after-the-...
After the Green New Deal
We need a clean energy strategy for a full employment economy
slowboring.com
1/n Our multi-ancestry #GWAS meta-analysis of major depression is now published in @cellpress.bsky.social. www.cell.com/cell/fulltex... A thread 🧵:
The Dimensional Turn in Psychopathology: Q&A with Robert F. Krueger “Everything we try as a field ends up illustrating how murky and complex the origins of psychopathology tend to be.” www.psychiatrymargins.com/p/the-dimens...
The Dimensional Turn in Psychopathology: Q&A with Robert Krueger
Distinguished McKnight University Professor at the University of Minnesota
psychiatrymargins.com
Who likes categories anyway? I wonder what this means for the concept of "areas"... #neuroscience www.thetransmitter.org/neural-codin...
Most neurons in mouse cortex defy functional categories
The majority of cells in the cerebral cortex are unspecialized, according to an unpublished analysis—and scientists need to take care in naming neurons, the researchers warn.
thetransmitter.org
Very glad to be invited at this Conference! Royal Society of Medicine,6-7 March "After Kraepelin: Ambitions, Images, Practices and the History of Psychiatry 1926-2026" I'll discuss the role of social values and collective emotions in the making of Asperger diagnosis www.rsm.ac.uk/events/psych...
After Kraepelin: Ambitions, images, Practices and the History of Psychiatry 1926-2026
This two-day event will review the ambitions, images and practices of psychiatry, as they have evolved during the period under review and seek pointers for continuity and transformation in the future.
rsm.ac.uk
I tried this BTW but while I approached both men and women, and both groups considered it, the men took me up on the offer, or volunteered (which is great!!). I decided I am not going forward if I can’t keep balance… ( pls volunteer!). This chat with eiko last yr is what I have in mind, sorta…
is this an accidental Podcast? Eiko Fried & Michel Nivard discuss a new GWAS of depression preprint
YouTube video by Michel's Science Speedrun
youtu.be
Last work tweet of 2024 (maybe 😉): I, Ken Kendler, Brad Verhulst, @jorsmo.bsky.social and @andrewgrotzinger.bsky.social et al in the Psychiatric Genomics Consortium Cross Disorder Group (PGC-CDG) wrote a review on challenges studying cross disorder (psych) genetics: www.nature.com/articles/s41...
Assessment and ascertainment in psychiatric molecular genetics: challenges and opportunities for cross-disorder research - Molecular Psychiatry
Molecular Psychiatry - Assessment and ascertainment in psychiatric molecular genetics: challenges and opportunities for cross-disorder research
nature.com
Now published (Neuroscience & Biobehavioral Reviews): "Relational neuroscience: Insights from hyperscanning research" We introduce #RelationalNeuroscience as a framework for research on inter-brain dynamics. We state that #hyperscanning is the prime methodology informing Relational Neuroscience.
Relational neuroscience: Insights from hyperscanning research
Humans are highly social, typically without this ability requiring noticeable efforts. Yet, such social fluency poses challenges both for the human br…
sciencedirect.com
I wrote about how polygenic heritable conditions present in families and the liability threshold model. This has some counterintuitive implications for considering the risk of a condition in offspring as well as the impact of multi-generational selection. A 🧵:
What happens to heritable conditions across generations?
some counterintuitive properties of the polygenic liability threshold model
open.substack.com
You've heard of DNA, but what about GNA? Very excited about this preprint with @jgthorp.bsky.social and others that introduces Genomic Network Analysis (GNA), an open-source multivariate tool for performing network analysis using GWAS summary statistics as input. 1/2 www.medrxiv.org/content/10.1...
Genomic network analysis characterizes genetic architecture and identifies trait-specific biology
Pervasive genetic overlap across human complex traits necessitates developing multivariate methods that can parse pleiotropic and trait-specific genetic signals. Here, we introduce Genomic Network Ana...
medrxiv.org
www.biorxiv.org/content/10.1... Smart study to test whether lower prediction accuracy in non-Europeans is due to between-population differences in population structure, genetic nurture, or assortative mating.
Within-Family GWAS does not Ameliorate the Decline in Prediction Accuracy across Populations
As polygenic prediction extends beyond the research domain to involve clinical applications, the urgency of solving the "portability problem" becomes amplified -- that is, the fact that polygenic indi...
biorxiv.org
onlinelibrary.wiley.com/doi/10.1111/...
Pathway to terrorist behaviors: The role of childhood experiences, personality traits, and ideological motivations in a sample of Iraqi prisoners
Radicalization to terrorism is a multifaceted process with no single theory or approach to explain it. Although research has focused on understanding the process, there is still a dearth of studies t...
onlinelibrary.wiley.com
I am proud to share our latest paper📜 “The multi-scale complexity of human genetic variation beyond continental groups”, just pre-printed on @biorxivpreprint.bsky.social ! Link Here ➡️ www.biorxiv.org/content/10.1...
The multi-scale complexity of human genetic variation beyond continental groups
Traditional clustering and visualization approaches in human genetics often operate under frameworks that assume inherent, discrete groupings1,2. These methods can inadvertently simplify multifaceted ...
biorxiv.org
Racism-based potentially traumatic experiences (rPTEs) can be seen as a form of moral injury, reflecting the deep psychological distress tied to violations of core moral values. This perspective highlights their link to PTSD, emphasizing the profound impact of systemic injustice on mental health.
Is racism like other trauma exposures? Examining the unique mental health effects of racial/ethnic discrimination on posttraumatic stress disorder (PTSD), major depressive disorder (MDD), and generali...
Galán, C. A., et al. (2024). The American journal of orthopsychiatry, 10.1037/ort0000807. Advance online publication. https://doi.org/10.103...
ethicalpsychology.com
Time spent on social media among the least influential factors in adolescent mental health: preliminary results from a panel network analysis. www.nature.com/articles/s44...
Time spent on social media among the least influential factors in adolescent mental health: preliminary results from a panel network analysis - Nature Mental Health
Panayiotou et al. performed a panel network analysis to investigate the relationship between time spent on social media and mental health in a large cohort of UK adolescents.
nature.com
Out now in Nature from @behrenstimb.bsky.social and crew: www.nature.com/articles/s41... Understanding this kind of schematic pattern learning and transfer will be key, IMO, to moving towards models of what we might call "higher-order cognition" or "reasoning". 🧠📈 🧪
A cellular basis for mapping behavioural structure - Nature
Mice generalize complex task structures by using neurons in the medial frontal cortex that encode progress to task goals and embed behavioural sequences.
nature.com
1/n. Getting more excited about exercise and physical activity as a middle way for mild to moderate internalizing illness. Middle insofar as biol (rather than psychosocial), but not drug or scalp stimulation. jamanetwork.com/journals/jam...
Daily Step Count and Depression in Adults
This systematic review and meta-analysis of observational studies examines associations between objectively measured daily step counts and depression in the general adult population.
jamanetwork.com
Out today: cross-species improvement of cognitive flexibility www.science.org/doi/10.1126/... The TLDR: remember when we improved human cognition with deep brain stimulation? (pubmed.ncbi.nlm.nih.gov/34725508/) Well, now we did it in rats, and it works the same! Specifically... 1/
Striatal stimulation enhances cognitive control and evidence processing in rodents and humans
Developing an animal model of human brain stimulation therapy reveals that striatal DBS enhances the brain’s ability to process conflicting evidence.
science.org
#Move. "...higher daily step counts were associated with fewer depressive symptoms in the general adult population." Daily Step Count and Depression in Adults jamanetwork.com/journals/jam... "...a daily active lifestyle may be a crucial factor in regulating and reinforcing these pathways."
Daily Step Count and Depression in Adults
This systematic review and meta-analysis of observational studies examines associations between objectively measured daily step counts and depression in the general adult population.
jamanetwork.com
This also is an important point. Undergoing intensive training on the Knowledge is a specific feature of London taxi drivers that is not typical elsewhere.
Hugo Spiers@hugospiers.bsky.social · 2y agoMy group have been studying London licensed taxi drivers to understand more about their impressive capacity to plan routes. These experts are v different from most taxi drivers, as they need to memorize many thousands of street names and places (The Knowlege) to pass an exam to operate. Thus...
This paper on the usefulness of diversity of neuron types is pretty cool: journals.plos.org/ploscompbiol...
Adapting to time: Why nature may have evolved a diverse set of neurons
Author summary The impressive successes of artificial neural networks (ANNs) in solving a range of challenging artificial intelligence tasks have led many researchers to explore the similarities betwe...
journals.plos.org