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James Nathan

@jamesnathanlab.bsky.social

Professor of Respiratory Medicine, University of Cambridge. Cellular mechanisms of oxygen sensing and metabolism. https://jamesnathanlab.co.uk/

13 Posts659 Follower196 Folgt
Medicine at Cambridge@medcambridge.bsky.social · 2mo ago

🔬 Respiratory Mechanisms of Disease (RC49887) Join @jamesnathanlab.bsky.social at #CITIID & @mitogene.bsky.social @mrc-mbu.bsky.social to investigate how mitochondrial dysfunction and mtDNA damage drive innate immune activation and contribute to COPD. 📅 Closing date: 5 July 2026 🔗 buff.ly/ujQDD8l

CG-TIC Postdoctoral Research Associate (Fixed Term)

We are seeking an experienced and motivated researcher to work on a Cambridge-GSK Translational Immunology Collaboration (CG-TIC) project. CG-TIC is a new translational initiative between Cambridge…

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Ram Chakrabarty@rpc3312.bsky.social · 3mo ago

Very happy to share our new paper. Together with our wonderful collaborators, we found that L-2-HG, a metabolite often viewed as “toxic,” also has an essential physiological function in mice. www.nature.com/articles/s41...

Mitochondrial l-2-hydroxyglutarate is a physiological signalling metabolite - Nature

l-2-Hydroxyglutarate is identified as a legitimate physiological signalling metabolite, and control of its levels is essential for postnatal growth and survival and correct renal development and funct...

nature.com

Helena Cocheme@cochemelab.bsky.social · 3mo ago

📍 Registration is now open for this #Redox #BiochemicalSociety Meeting! Excellent invited speakers, plus many slots for elevated talks from abstracts, including #ECRs 🫵 🌍 Cambridge, UK 🗓️ 16-18 Nov 2026 ⏳ Super early bird deadline: 16 Aug 2026 🌐 bit.ly/Redox-26 #BiochemEvent @biochemsoc.bsky.social

Redox – The Good, The Bad and The Unexpected

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Biochemical Society@biochemsoc.bsky.social · 3mo ago

Join us in Cambridge from 16-18 November 2026 to celebrate the latest research in redox biology! Featuring insights into redox regulation, metabolism, cell death, hypoxia and more. Organised by @cochemelab.bsky.social, @jamesnathanlab.bsky.social, Phil Eaton and Andy Finch: https://ow.ly/UbTJ50YZxFg

Redox - The Good, The Bad, and The Unexpected scientific meeting in Cambridge, UK from 16-18 November 2026 Super earlybird deadline 16 August 2026
James Nathan@jamesnathanlab.bsky.social · 5mo ago

Delighted to share the 'early access' version of our work examining genetic dependencies with VHL loss in ccRCC. Led by James Bertlin. Thanks to our wonderful collaborators Qing Zhang, Annie Speak, Tom Mitchell. Presenting the work today at #AACRkidney26 www.nature.com/articles/s41...

VHL synthetic lethality screens uncover CBF-β as a negative regulator of STING - Nature Communications

Biallelic inactivation of the VHL tumour suppressor gene is a hallmark of Clear cell renal cell carcinoma (ccRCC). Here the authors perform genome-wide CRISPR/Cas9 screening to identify that loss of C...

nature.com

The Lister Institute of Preventive Medicine@thelisterinstitute.bsky.social · 11mo ago

Congrats to #ListerFellow @jamesnathanlab.bsky.social and team on this tremendous paper in Science Advances exploring iron flux and metabolism. "Potentially explaining how some tumors evade antitumoral immunity."

James Nathan@jamesnathanlab.bsky.social · 11mo ago

Happy to share latest work from the lab. Led by talented first author @awmartinelli.bsky.social. Mapping the genetic landscape of iron metabolism uncovers the SETD2 methyltransferase as a modulator of iron flux | Science Advances www.science.org/doi/10.1126/... Congratulations to all the team.

James Nathan@jamesnathanlab.bsky.social · 11mo ago

Happy to share latest work from the lab. Led by talented first author @awmartinelli.bsky.social. Mapping the genetic landscape of iron metabolism uncovers the SETD2 methyltransferase as a modulator of iron flux | Science Advances www.science.org/doi/10.1126/... Congratulations to all the team.

Mapping the genetic landscape of iron metabolism uncovers the SETD2 methyltransferase as a modulator of iron flux

Genetic screens using endogenous reporters map key modulators of cellular iron, including the transcriptional regulator SETD2.

science.org

Medicine at Cambridge@medcambridge.bsky.social · last yr.

🧬 New in @natchembio.nature.com : Researchers at #CITIID @cam.ac.uk & @ki.se identified #ABHD11 – a key enzyme that controls cellular energy production & immune response. Learn more: buff.ly/ZdOAdLe @hudsonwilco.bsky.social @jamesnathanlab.bsky.social

New study reveals key enzyme to control cellular energy production and immune function | Cambridge Institute for Therapeutic Immunology and Infectious Disease (CITIID)

Uncovering ABHD11 as a key metabolic regulator could lead to new treatments for cancer, autoimmune diseases, and metabolic disorders.

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James Nathan@jamesnathanlab.bsky.social · last yr.

Delighted to share our latest work on ABHD11 as a novel deglutarylating enzyme, and its role in T cell metabolism @natchembio.nature.com rdcu.be/ewiYZ. Many congratulations to co-first authors Guine Grice, Eleanor Minogue and @hudsonwilco.bsky.social! Great team effort with Randall Johnson's lab.

Lipoyl deglutarylation by ABHD11 regulates mitochondrial and T cell metabolism

Nature Chemical Biology - Glutarate rewires cell metabolism through conjugation to proteins or fatty acids, but how glutarylation is regulated is unclear. ABHD11 was identified as a...

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James Nathan@jamesnathanlab.bsky.social · 2y ago

Having just joined bsky, thought it would be good to share our latest review and a couple of recent preprints from the group. First our review on the roles of deubiquitinating enzymes in hypoxia responses. portlandpress.com/biochemsoctr...

A closer look at the role of deubiquitinating enzymes in the Hypoxia Inducible Factor pathway

Hypoxia Inducible transcription Factors (HIFs) are central to the metazoan oxygen-sensing response. Under low oxygen conditions (hypoxia), HIFs are stabilised and govern an adaptive transcriptional pr...

portlandpress.com