If you study microglia in mice using CX3CR1-creERT2 or PLX drugs, our latest paper led by Isaac Babcock in Cell Reports is a must-read. TL;DR: CX3CR1-creERT2 hits peripheral macrophages long-term. PLX 5622 deletes them too. But combining them fixes the issue. #microglia #immunology (1/9)

Neurons undergo IFNγ-driven persistent epigenetic shifts and synaptopathy in encephalitis: Neuron www.cell.com/neuron/fullt...

Neurons undergo IFNγ-driven persistent epigenetic shifts and synaptopathy in encephalitis

Shammas et al. show a neuronal epigenetic remodeling during CNS encephalitis. This program involves IFNγ-driven persistent reduction in TF-binding site accessibility, linked to long-lasting reduction ...

cell.com

Caspase-8 expression in CD8+ T cells promotes pathogen restriction in the brain during Toxoplasma gondii infection www.science.org/doi/10.1126/...

Checkout this comprehensive review paper written by Jiabo Li of the Daniel Brat lab on the immunopathology of glioblastoma! 👏🏼 www.annualreviews.org/content/jour...

Immunopathology of Glioblastoma

Glioblastoma (GBM), the most frequent and malignant primary brain tumor, is characterized by a highly diverse and profoundly immunosuppressive tumor microenvironment (TME) that provides an unconstrain...

annualreviews.org

The immunology of brain tumors | Science Immunology www.science.org/doi/10.1126/... Happy to share this review article by @lukasbunse.bsky.social, Theresa Bunse and I @platten-lab.bsky.social, Michael Kilian, Fran Quintana @quintanalabhms.bsky.social.

The immunology of brain tumors

The cellular and molecular determinants of the antigenicity of brain tumors and the immunosuppressive brain tumor microenvironment are reviewed.

science.org

Everything you wanted to know about oxidized lipids & immunity, in one review. We explain how oxidized lipids impact inflammation, dendritic cells, anti-tumor immunity and more. Kudos to Joon Choi for his exceptional work. royalsocietypublishing.org/doi/10.1098/...

Oxidized phospholipid damage signals as modulators of immunity | Open Biology

Damage-associated molecular patterns (DAMPs) are self-derived molecules released during tissue damage that influence immune responses. Phospholipids, essential to cell membranes and lung surfactants, ...

royalsocietypublishing.org

I've been really hoping to see more manuscript threads here on 🦋, so here comes one!!! This is brand new work from the lab that took us in very unexpected directions and to exciting findings led by the amazing @emily-hill.bsky.social. Preprint here www.biorxiv.org/content/10.1... and 🧵below:

Our newest paper studying immunosuppressive astrocyte-GBM interactions using RABID-seq is out in ‪@nature.com today! Congrats to Brian Andersen and Camilo Faust Akl! www.nature.com/articles/s41...

Barcoded viral tracing identifies immunosuppressive astrocyte–glioma interactions - Nature

Using viral barcode tracing to detect interactions between glioblastoma cells and non-malignant astrocytes in patient samples, investigators discovered a pathway that reduces tumour-specific immunity ...

nature.com

Time is running out to register for the AAI Introductory Course in Immunology! Join me and other expert faculty in LA from July 8-13 to expand your knowledge of the immune system. I will be lecturing on neuroimmunology. @aai.org www.aai.org/Education/Co...

Excited to share our new paper out in @cp-neuron.bsky.social today! We discovered the neuroanatomical route that myeloid cells use to enter the brain parenchyma. Check it out here: authors.elsevier.com/c/1lCYs3BtfH...

Abstract deadline extended to May 23rd! Join us in NYC in Sept 2025 for the Cell Symposium "The Neuro-immune Axis: Charting the periphery" #CSNeuroimmune25 #neuroimmunology Organized by @cp-neuron.bsky.social, @kavithascranton.bsky.social, Brian Kim & David Artis hubs.ly/Q03gmh5w0

The Venkatesh Lab is looking for a Sr. Lab Technician to help support ongoing projects focused on the peripheral nervous system & its interactions with cancers. Check out the posting below! massgeneralbrigham.wd1.myworkdayjobs.com/en-US/MGBExt...

Check out our special collection on #neuroimmunology that is online now! www.cell.com/immuni/newar... #AAI2025

We are excited to share our new study @cp-cancercell.bsky.social identifying Zeb2 as a master genetic switch controlling the tumor-associated macrophage (TAM) program. Led by Fadi Sheban, Truong San Phan, Kai Kun Xie & @florianingelfinger.bsky.social. (1/20) www.cell.com/cancer-cell/...

ZEB2 is a master switch controlling the tumor-associated macrophage program

Sheban et al. present a single-cell CRISPR screen to dissect macrophage gene regulation in a pan-cancer tumor-associated macrophage (TAM) atlas. Using a generative model, they identify ZEB2 as a key d...

cell.com

🚀 New publication! We developed a PTPRZ1-specific TCR-T cell therapy for glioblastoma. 🔬 Key findings: ✅ Identified a PTPRZ1-reactive TCR from a vaccinated patient ✅ Kills glioblastoma cells with no off-target effects ✅ Eliminates tumors in murine brain models 🔗 www.nature.com/articles/s41...

Vaccine-induced T cell receptor T cell therapy targeting a glioblastoma stemness antigen - Nature Communications

Vaccination in glioblastomas does lead to the emergence of tumour-antigen-specific T cells but T cell dysfunction, poor tumour infiltration and persistence hinder efficient tumour killing. Here author...

nature.com

Know anyone looking for a lab specialist/technician job? The Ross lab is hiring! This position will help the lab with our research on anti-tumor immunity in high-grade glioma. Incredible training environment!! 🐭🔬🧪🦠🧠 jobs.virginia.edu/us/en/job/R0...

Lab Tech/Specialist Varying Levels - Neuroscience in Charlottesville, Virginia, United States of America | Research at University of Virginia

Apply for Lab Tech/Specialist Varying Levels - Neuroscience job with University of Virginia in Charlottesville, Virginia, United States of America. Research at University of Virginia

jobs.virginia.edu

Fantastic lineup of speakers. Looking forward to this!

Jonathan Kipnis@jonykipnis.bsky.social · last yr.

‼️BIG news ‼️ #ReThinkNeuroimmunology #RTN registration is open and live! The program is amazing! Hurry up to register while prices are low! See you in Boston in October! genelayinstitute.org/rtn/

Why do brain metastases resist #immunotherapy — even when the same cancer responds outside the #brain? 🧠🧪💥 We just published a study diving into this question ⏬ Led by an amazing (former) PhD student in my lab —Vladimir Wischnewski 🎉 🧵 1/ @cp-cellreports.bsky.social www.cell.com/cell-reports...

Harnessing microglia-based cell therapies for the treatment of neurodegenerative diseases www.sciencedirect.com/science/arti...

Excited to see two brilliant brain tumor neuroscientists win this award. Their work has inspired much of the field, and certainly my own work.

The Brain Prize@brainprize.org · last yr.

Congratulations to winners of The Brain Prize 2025! Professors @michellemonje.bsky.social, @stanfordmedicine.bsky.social and @hhmi.org Investigator, and Frank Winkler, Heidelberg University Hospital, have pioneered the field of Cancer Neuroscience. Learn more: brainprize.org/winners/canc...

Very cool to see this manuscript by Dan Brat’s lab on inducing photothrombosis in live glioblastoma bearing mice utilizing two photon microscopy to study the events of necrosis on tumor progression. I started this project as a first year grad student and his current student “wrapped” this up. 🔬⚡️🧠

Hi Y’all-this paper out in print now sheds new light on how nutrients can affect histone acetylation in a locus-specific manner…in other words “you are what you eat”!

Sarah Ross@sarahhross.bsky.social · 2y ago

ICYMI by First Release - now officially in print @science.org Specific combinations of nutrients and metabolic enzymes determine T cell differentiation via loci-specific histone acetylations. https://buff.ly/4gvqKTz From Shixin Ma, Sue Kaech @tcellogic.bsky.social et al. #immunometabolism

Excited to share a new paper from our lab 😀 We investigate the tumor microenvironment - to reveal factors influencing cancer progression & therapy response 🔬🧪 So we naturally wanted to ask - does the gut #microbiome influence brain #metastasis 🦠 🧠? Massara et al 2025 www.cell.com/iscience/ful...