We are looking for an amazing person to join our team as a Project Manager to support me across a portfolio of child and adolescent TB studies. Use the following link su.ac.za/en/careers-su to apply.
Careers at SU
Careers at SU
su.ac.za
James Seddon
@jaseddon.bsky.social
Paediatric Infectious Diseases doctor and TBologist
Exciting opportunity for a Medical Officer and a Study Nurse to join our research team at the Desmond Tutu TB Centre to work on the newly funded DEFIANT study to evaluate the impact of puberty on host immune responses to Mtb. www.linkedin.com/jobs/view/44... www.linkedin.com/jobs/view/44...
Stellenbosch University hiring Medical Officer in Stellenbosch, Western Cape, South Africa | LinkedIn
Posted 12:42:57 PM. Department Description/Departement BeskrywingFaculty of Medicine and Health SciencesDesmond Tutu TB…See this and similar jobs on LinkedIn.
linkedin.com
So...what would happen to the global TB epidemic if we "eliminated" undernutrition? Our paper out now @lancetgh.bsky.social, where we combined estimates from our review (academic.oup.com/ije/article/...) with population-specific BMI distributions to find out...(www.thelancet.com/journals/lan...
Global, regional, and national estimates of tuberculosis incidence averted by eliminating undernutrition in adults: a modelling study
Almost a quarter of global tuberculosis incidence in adults could be averted by eliminating undernutrition, approximately two-and-a-half times higher than current estimates. These findings highlight t...
thelancet.com
So...what would happen to the global TB epidemic if we "eliminated" undernutrition? Our paper out now @lancetgh.bsky.social, where we combined estimates from our review (doi.org/10.1093/ije/...) with population-specific BMI distributions to find out...(www.sciencedirect.com/science/arti...)
Global, regional, and national estimates of tuberculosis incidence averted by eliminating undernutrition in adults: a modelling study
Current efforts to reduce global tuberculosis incidence have proved insufficient, highlighting that urgent action is needed to address underlying modi…
sciencedirect.com
New comment: Tuberculosis and undernutrition: improving estimates to reinforce the policy imperative www.thelancet.com/journals/lan...
Tuberculosis and undernutrition: improving estimates to reinforce the policy imperative
Undernutrition is a key driver of the global tuberculosis epidemic, increasing the risk of people developing tuberculosis disease and of poor outcomes in those who do.1 Each year, WHO publishes estima...
thelancet.com
Great to see this published after the hard work in Stockholm and Cape Town! How should we think about aerosol detection of #tuberculosis? Is it a diagnostic test? Could it help us prioritize prevention activities? Much more work to do, but exciting nonetheless @climeresearchgroup.bsky.social @ki.se
Open Forum Infectious Diseases@ofidjournal.bsky.social · 10mo agoDetection of aerosolized Mycobacterium tuberculosis DNA from adults being investigated for pulmonary tuberculosis using an electrostatic sampler in a South African primary care setting ✅ Just Accepted #IDSky 🔗 https://bit.ly/474fRq0
So...what would happen to the global TB epidemic if we hypothetically "eliminated" undernutrition? In this preprint, we combined estimates from our new review (doi.org/10.1093/ije/...) with population-specific BMI distributions to find out...(doi.org/10.1101/2025...)
Global, regional, and national estimates of tuberculosis incidence averted by eliminating undernutrition in adults: a modelling study
Background Current efforts to reduce global tuberculosis incidence have proved insufficient, highlighting that urgent action is needed to address underlying modifiable risk factors such as undernutrit...
doi.org
Although several AI algorithms can interpret chest x-rays for TB, we still do not have validated or approved CAD products for children. With @jaseddon.bsky.social and colleagues, we shared our thoughts on how to advance CAD for #pediatricTB: www.thelancet.com/journals/lan... #tbsky #idsky
Computer-aided reading of chest radiographs for paediatric tuberculosis: current status and future directions
Computer-aided detection (CAD) systems for automated reading of chest x-rays (CXRs) have been developed and approved for tuberculosis triage in adults but not in children. However, CXR is frequently t...
thelancet.com
A clinical practice guideline for tuberculous meningitis Tuberculous Meningitis International Research Consortium www.thelancet.com/journals/lan... 🔒
A clinical practice guideline for tuberculous meningitis
Tuberculous meningitis is the most severe form of tuberculosis, causing death or disability in around half of those affected. There are no up-to-date international guidelines defining its optimal mana...
thelancet.com
Meet the antivax whisperer trying to turnaround Britain's child vaccine slump one family at a time. How does she do it? What does she say? Interview with Professor Elizabeth Whittaker: www.thetimes.com/article/26a8...
Meet the antivax whisperer fighting the vaccine slump
Professor Elizabeth Whittaker convinces reluctant parents to get their children jabbed — and has seen the horrors that unchecked diseases like measles inflict
thetimes.com
Impact of puberty on immune responses to Mycobacterium tuberculosis in South African adolescents ✅ Just Accepted #IDSky
Impact of puberty on immune responses to Mycobacterium tuberculosis in South African adolescents
As individuals progress through adolescence, their risk of tuberculosis (TB) increases and the type of disease that develops changes, with increasing cavitary formation and parenchymal tissue destruction.
doi.org
Loads of amazing colleagues have contributed to this review of the management of individuals exposed to MDR/RR-TB. www.thelancet.com/journals/lan...
Management of individuals exposed to multidrug-resistant or rifampicin-resistant tuberculosis
Individuals exposed to a person with infectious multidrug-resistant or rifampicin-resistant (MDR-RR) tuberculosis are at risk of developing tuberculosis disease. Historically, insufficient empirical e...
thelancet.com
TB seems to comprehensively disrupt the normal physiological progression of puberty. academic.oup.com/jid/advance-...
Impact of puberty on immune responses to Mycobacterium tuberculosis in South African adolescents
AbstractBackground. As individuals progress through adolescence, their risk of tuberculosis (TB) increases and the type of disease that develops changes, w
academic.oup.com
Risk of tuberculosis infection in young children exposed to multidrug-resistant tuberculosis in the TB-CHAMP multi-site randomised controlled trial ✅ Just Accepted #IDSky
Risk of tuberculosis infection in young children exposed to multidrug-resistant tuberculosis in the TB-CHAMP multi-site randomised controlled trial
Young children have a high risk of developing tuberculosis (TB) disease following infection with Mycobacterium tuberculosis in the absence of preventive treatment.
doi.org
Brilliant work by @cfmcquaid.bsky.social and Matt Saunders! Their updated analysis— a MOUNTAIN of work— shows that an increase in 1 unit of BMI reduces TB risk by 12.3%. @theunion-tblh.bsky.social @jasonandrews.bsky.social @madhupai.bsky.social Link: papers.ssrn.com/sol3/papers....
Tuberculosis Incidence and Body Mass Index – An Updated Systematic Literature Review and Global Analysis
Background: Undernutrition is the leading population-level determinant of tuberculosis, but the relationship between tuberculosis and nutritional status remains
papers.ssrn.com
In the endTB trial, researchers assessed the efficacy and safety of five 9-month, all-oral treatment regimens, as compared with the evolving standard of care, in participants with rifampin-resistant, fluoroquinolone-susceptible tuberculosis. nej.md/3WFFJTv #MedSky #IDSky
Interesting paper published today in Chest, led by Cheng Chen and Leo Martinez. High frequency of reversions observed when serial QTF is performed. Reversion rates decreased with time from exposure and at older ages. Data from 4 different countries @chest linkinghub.elsevier.com/retrieve/pii...
Redirecting
linkinghub.elsevier.com
Proud to see the endTB trial, work of a huge team, led by @partnersinhealth.bsky.social, @msf.org, IRD & supported by @unitaid.bsky.social, published in @nejm.org today. Safe, effective, shortened treatments for drug-resistant TB can be available to all. #TBSky #ForeignAid tinyurl.com/NEJM-endTB
Oral Regimens for Rifampin-Resistant, Fluoroquinolone-Susceptible Tuberculosis | NEJM
For decades, poor treatment options and low-quality evidence plagued care for patients with rifampin-resistant tuberculosis. The advent of new drugs to treat tuberculosis and enhanced funding now p...
tinyurl.com
Happy to have been part of the mammoth team effort reviewing and modelling the burden of TBM in children #TBsky www.sciencedirect.com/science/arti...
Global burden of tuberculous meningitis in children aged 0–14 years in 2019: a mathematical modelling study
Tuberculous meningitis is fatal if untreated and can lead to lifelong neurological sequelae. However, to our knowledge, there are no data on the numbe…
sciencedirect.com
Nice to see VQUIN and TB-CHAMP finally out. Both studies evaluated levofloxacin (compared w/placebo) as preventive treatment for MDR TB contacts. Meta-analysis showed 60% reduction: evidence.nejm.org/doi/full/10.... Each study: www.nejm.org/doi/full/10.... www.nejm.org/doi/full/10....
A Meta-Analysis of Levofloxacin for Contacts of Multidrug-Resistant Tuberculosis
Data from randomized trials evaluating the effectiveness of tuberculosis (TB) preventive treatment for contacts of multidrug-resistant (MDR)-TB are lacking. Two recently published randomized trials...
evidence.nejm.org
And finally the meta-analysis of the two trials in NEJM Evidence with a nice article on the world's weird obsession with P values. evidence.nejm.org/doi/full/10.... evidence.nejm.org/doi/full/10....
This journey began for me in 2009. Beyond excited to see this now out in print. Thank you to everyone (a very large cast) who made this happen. www.nejm.org/doi/full/10....
A reminder on #WorldChildrensDay that 1.3million children fell ill with #tuberculosis in 2023, causing 200,000 paediatric deaths from a disease that's curable & preventable. Govts & funders must urgently prioritise children in research funding & program implementation. msfaccess.org/tactic-test-...
TACTIC: Test, Avoid, Cure TB in Children
Survey of adoption of WHO paediatric TB guidelines into national policy frameworks in 14 countries
msfaccess.org