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Jasper Gomez

@jasgomez.bsky.social

Postdoc in Vaughn Coopers lab @ University of Pittsburgh. Interested in phages, microbes, evolution and phage therapy.

4 Posts51 Follower93 Folgt
Vaughn Cooper@vscooper.micropopbio.org · 2d ago

How do Burkholderia multivorans bacteria adaptively evolve during infections of the cystic fibrosis airway? A longtime collab and intensive study of 8 patients links bacterial adaptations to disease progression. Our findings also unite prior studies. www.biorxiv.org/content/10.6...

Convergent genetic evolution within Burkholderia multivorans chronic infections correlates with lung function decline in cystic fibrosis patients

The patterns and pathways of pathogen adaptation during chronic infections can reveal the gateways microbes must unlock to colonize and persist. In chronic lung infections of cystic fibrosis (CF) pati...

biorxiv.org

Jasper Gomez@jasgomez.bsky.social · last mo.

My PhD work with my awesome mentor Chris Waters and collaborator Jeff Barrick looking at how phages encode contingency loci to overcome phage defense systems and potentially other stresses via phase variation is out! www.nature.com/articles/s41...

Phage-encoded contingency loci enable bet-hedging against host defence mechanisms - Nature Microbiology

Diverse E. coli phage genomes have hypermutable DNA regions that promote reversible frameshift mutations through DNA polymerase slippage, generating population heterogeneity that enables host exploita...

nature.com

Drew Bridges@bridgesbio.bsky.social · 5mo ago

New preprint: "A branching cell-fate decision in biofilm dispersal enables long-term surface persistence." When V. cholerae biofilms disperse, it isn’t a uniform exit, rather, an opportunity to bet-hedge. A subpopulation of cells stay behind, primed for biofilm regrowth. doi.org/10.64898/202...

Simon Fisher@profsimonfisher.bsky.social · 6mo ago

Project Hail Mary is a beautiful brilliant film. But molecular biologists be warned there's a deeply disturbing scene midway through when Ryan Gosling's scientist places two eppendorfs directly next to each other in an otherwise empty unbalanced microcentrifuge & sets it spinning with wild abandon.

Kyle Card@kylejcard.bsky.social · 11mo ago

I don't understand why groups design plasmids, publish protocol papers centered on their use, and then not deposit them to Addgene. Open, reproducible science should be our North Star, not an afterthought (or worse, never considered at all).

Vaughn Cooper@vscooper.micropopbio.org · 12mo ago

Terrific writeup of our new paper led by @nanamikubota.bsky.social, thanks Pitt media! www.medschool.pitt.edu/news/bacteri...

Bacteria Can Use Viruses to Kill Other Bacteria, Pitt Researchers Find | School of Medicine | University of Pittsburgh

Many bacteria, including the opportunistic pathogen Pseudomonas aeruginosa, are chronically infected by viruses that can reproduce without killing the cell. These viruses, called filamentous phages, t...

medschool.pitt.edu

Nanami Kubota@nanamikubota.bsky.social · 12mo ago

Published in Current Biology! P. aeruginosa can use its filamentous phage to inhibit competitors but high phage production is susceptible to cheater miniphage invasion. Subsequent phage tragedy of the commons can lower bacteria and phage fitness. Link: authors.elsevier.com/c/1lt5I3QW8S...

Nanami Kubota@nanamikubota.bsky.social · last yr.

Preprint out! Bacteria w/ hyper-replicative filamentous phage lead to overnight emergence of cheater phages. Bacteria w/ both phages can outcompete wildtype, then rapidly lose phage via a phage Tragedy of the Commons @shellyscrib.bsky.social @vscooper.micropopbio.org www.biorxiv.org/content/10.1...

Aathmaja@aathmaja.bsky.social · last yr.

Check out my recent publication on how zinc and quorum sensing affects cyclic di GMP in V. cholerae. share.google/JaOJv48OAhH4...

A cyclic di-GMP phosphodiesterase in the VSP-2 island of Vibrio cholerae is regulated by zinc and quorum sensing | mBio

Vibrio cholerae colonizes estuarine environments and human hosts, where it transitions between motile and sessile states using the second messenger cyclic di-GMP (cdG). cdG levels change in response to a variety of signals and are controlled by the activity of diguanylate cyclases and phosphodiesterase (PDEs), enzymes that make and degrade cdG. In this work, we show that Zn2+ and the cell density regulator HapR repress ZpdA, the PDE present in the Vibrio seventh pandemic 2 island, at the level of transcription, and that Zn2+ unexpectedly alters the PDE activity of ZpdA protein itself. Our study highlights the role of metal availability as an important signaling cue that controls V. cholerae biology.

share.google

Vaughn Cooper@vscooper.micropopbio.org · last yr.

I am DEEPLY SYMPATHETIC that the NIH staff are working desperately hard in the hurt locker. I am grateful that they hold the fort. But, to the admin: YOU BROKE IT, YOU BOUGHT IT. Most folks want tax $ to support this work, and they will vote accordingly if they know about this. Share and speak up!

Devin Lake@devinmlake.bsky.social · last yr.

I couldn’t be more proud of STEPS! Hats off to Zach, Mina, and Rich (@relenski.bsky.social) for all their hard work on the project. I look forward to adding new features and fighting with inevitable bugs in the future!

Richard Lenski@relenski.bsky.social · last yr.

Excited to share new #program, STEPS, which can simulate #dynamics of the E. coli Long-Term Evolution Experiment (#LTEE) or other microbes in serial transfer regime. telliamedrevisited.wordpress.com/2025/08/12/s... STEPS developed by @devinmlake.bsky.social, Zachary Matson, Minako Izutsu, and me.

Vivek Mutalik@vivekmutalik.bsky.social · last yr.

Hey folks in academic world: be nice & respectful to the invited speakers. That includes: students, postdocs, & early career scientists. If you are disrespectful, know that this world is round & Karma will catch up w you very quick.

Aathmaja@aathmaja.bsky.social · last yr.

Excited to attend my first ASM microbe this year at LA. Will be presenting my postdoctoral work from Waters lab on "Zinc regulation of cyclic di-GMP in V. Cholerae" in Room 408B from 3.30-3.45 on June 20th. Looking forward to seeing you all there. #asm2025

Nanami Kubota@nanamikubota.bsky.social · last yr.

Cooper lab is at #ASMicrobe ! See the thread for a list of all our presentations. Interested in filamentous cheater phages of P. aeruginosa? I'll be talking about them tomorrow Friday from 9:45-10am at the "Who Runs the World? Phage" session (408B, LACC)

Vaughn Cooper@vscooper.micropopbio.org · last yr.

Welcome to all attending @asm.org #Microbe2025 and to all following here. Looking forward to a great meeting! Delighted that many labmates & colleagues are presenting, as follows, and to celebrate the publication of the Academy's Early Microbial Life report, which I co-chaired. Check these out!🧵