“Amdahl’s law: the speedup achievable by optimizing one component of a system is limited by the fraction of total time that component represents.”

Ran Blekhman@blekhman.bsky.social · last wk.

Everyone says AI will accelerate science. I don't think it will -- at least not in biology, and at least not soon. New post where I explain why, and how the productivity paradox can be resolved: blekhman.substack.com/p/why-ai-wil...

We are hiring! Are you an ambitious postdoc with a background in vascular bioengineering and cell biology? Then please join our team at Amsterdam UMC and help unravel the mechanisms that govern vascular integrity. #embobuildnetworks #vascularbiology #EVBO werkenbij.amsterdamumc.org/en/vacatures...

Vacatures - Postdoc Vascular Biology - Amsterdam UMC

Are you an ambitious scientist with a background in vascular bioengineering and cell biology? Join our team at Amsterdam UMC and help unravel the mechanisms that govern vascular integrity.

werkenbij.amsterdamumc.org

Your budget quantifies your values.

Joel Boerckel@jboerckel.bsky.social · 2mo ago

Whenever I give department seminars, I try to make time to visit the uni library. The library is the heart of the university. The books and our monuments to them will outlast both us and the internet - if we preserve them. I haven’t visited MIT, but this feels like a death.

Whenever I give department seminars, I try to make time to visit the uni library. The library is the heart of the university. The books and our monuments to them will outlast both us and the internet - if we preserve them. I haven’t visited MIT, but this feels like a death.

eileen chengyin chow@chowleen.bsky.social · 2mo ago

“I write with dismay, grief and sorrow for the permanent closure of MIT Libraries Barker, Dewey and Rotch, and termination of library staff in those libraries. For MIT to be closing three of its four major libraries..." fnl.mit.edu/may-june-202...

It's time to rewrite reviews-aKG doesn't just regulate demethylation. Work from my lab and @mzspectrum.bsky.social demonstrates a new role for aKG in promoting histone acetylation and DNA repair through regulating carnitine synthesis. Congrats Apoorva Uboveja! www.nature.com/articles/s41...

αKG-mediated carnitine synthesis drives DNA repair via histone acetylation - Nature

The metabolite αKG promotes carnitine synthesis and increases site-specific histone acetylation, thereby promoting homologous recombination-mediated DNA repair, which has potential implications f...

nature.com

He warned us we'd have to remind you. "Particularly in times of international conflict, when the dominant definition of the situation is such as to emphasize national loyalties, the man of science is subjected to conflicting imperatives of scientific universalism and ethnocentric particularism."

“then it’s nothing for you to do but enjoy the few minutes you got left the best way you can-by killing somebody or burning down his house or doing some other meanness to him. No pleasure but meanness.” -Flannery www.nytimes.com/2026/05/22/u...

Green Card Seekers Must Leave U.S. to Apply, Trump Administration Says

nytimes.com

This was fitting news to receive on May 1, international workers day. I will be returning to work on Monday after being kept on retaliatory administrative leave for 5 months and 3 weeks. I return along with the brave Katrina Declaration signers from FEMA, also reinstated this week. 🧵1/?

Sheryl Gay Stolberg@sherylnyt.bsky.social · 3mo ago

NEWS: The NIH whistleblower @jenna-m-norton.bsky.social, who was put on paid leave in November after criticizing the Trump administration’s cuts to medical research, has been reinstated — without explanation. www.nytimes.com/2026/05/01/u...

Creative and elegant work - and well-told @deeparajan.bsky.social @wallaceucsf.bsky.social

Deepa Rajan, PhD@deeparajan.bsky.social · 3mo ago

How can a single cell learn without a brain? We explore this in my paper with @wallaceucsf.bsky.social! We discovered that single cells may learn using molecules similar to those that animal brains use to learn, like CaMKII. Cells can also propagate memory states to their progeny!

just got knocked over by this new paper from the Andrei Chagin lab: www.science.org/doi/epdf/10.... physically dropped the paper in delighted surprise when I got to the second half of Fig 5:

We’re hiring! Tenure-track faculty position in cancer research at LSU Health Shreveport (Pathology & Translational Pathobiology). Looking for investigators building programs at the interface of cancer, metabolism, inflammation, and vascular biology. www.lsuhsc.edu/shv/CareerOp...

Whole organism 3D mapping reveals universal branching topology and biophysical optimization governs vascular and nervous system development Read about our work here: www.biorxiv.org/content/10.6...

📣 New preprint alert! Co-authored by @spalaciosm.bsky.social and @andreacaldarola.bsky.social : Quantitative imaging of calcium dynamics with a green fluorescent biosensor and fluorescence lifetime imaging www.biorxiv.org/content/10.6...

Happy Easter! He is risen!

JBMR® Plus is accepting applications for editor‑in‑chief. Current EIC Deborah Veis, MD, PhD, calls the role one of the most impactful of her career. This paid position's term begins October 2026. Apply by April 3. www.surveymonkey.com/r/8FM2GFJ?ut... Learn More: www.asbmr.org/publications...

Amazing opportunity to work with Kim, who is the most creative scientist and an amazing mentor

Kim Cooper@ucsdcooperlab.bsky.social · 4mo ago

The Cooper lab is hiring a postdoc with a strong background in mouse genetics and molecular biology to advance.our gene drive work. Must be extremely organized, engineering-minded, and outcomes-oriented. Spread the word and have interested candidates email me directly.

Impossible to overstate how timely the @orssociety.bsky.social meeting feels, again, this year. Cannot wait to see dear friends and hear exciting science. Keep an eye out for these amazing scientists at #ORS2026 this week: @cpane94.bsky.social @gkotsaris90.bsky.social @eseidlscience.bsky.social

Introducing the #ORS2026 Spotlight Speakers! We are excited to welcome thesee internationally recognized experts, March 27–31, in Charlotte, NC, sharing insights across mechanobiology, regeneration, data-driven #orthopaedics, and more. 🔎 Learn more: https://www.ors.org/2026spotlightspeakers/

Congratulations to ISFR members @gkotsaris90.bsky.social and @amitsc.bsky.social for their nominations for the New Investigator Recognition Award! Be sure to add their talks to your schedule at #ORS2026 and catch their exciting work in bone fracture repair! 🦴🩻🔬

🎉 Congrats to our finalists for the ORS Business Innovation Competition at #ORS2026! BIC serves as a springboard for #msk innovation, supporting early-stage ideas as they move from the lab to the marketplace. Learn more about each finalist 👉 https://www.ors.org/2026bic .

5%ile is the new 10%ile and CND is just ND.

Joshua Weitz@joshuasweitz.bsky.social · 5mo ago

The data is in: the NIH goalposts have shifted. What were once almost certain fundable scores have become coin flips and what used to be likely grants have become aspirational, leading to fewer awards. Another manifestation of how HHS policies have led to fewer awards and less science.

In this world, shipmates, sin that pays its way can travel freely, and without a passport; whereas Virtue, if a pauper, is stopped at all frontiers. -Melville

Insight is *never* greater than the level of inquiry. I feel second hand embarrassment every time I hear a serious scientist claim an in vitro system/organoid/“NAM” can answer a question it was never intended to ask.

Thiago Carvalho@cyrilpedia.bsky.social · 5mo ago

In my simple brain, it's exciting but you need to understand the limitations: cell free systems allow you to ask q's about molecules; in vitro systems allow you to ask q's about molecules & cells; organoids may one day allow you to ask q's about mols, cells, and tissues/organs - but never organisms

Without considering the sources of claims, efforts at epistemic vigilance become play-acting. With LLMs, we don't know the sources. Excellent thread from @mjcrockett.bsky.social

M.J. Crockett@mjcrockett.bsky.social · 5mo ago

I'm a cognitive scientist with an interest in epistemic vigilance, and this essay that's been going around gave me pause. I don't think it's straightforward to apply the concept of epistemic vigilance to interactions with LLMs, as this essay does. 🧵/ sbgeoaiphd.github.io/rotating_the...

if you are writing, and need to decide between making things easier for you or easier for your reader (such as using an acronym or cutting white space to fit in more words), always -always- choose your reader. this tweet is not about AI, but it also is.

Let us call her Misty. Life, regeneration & rebirth - sounds right to me 🦛❤️ #worldhippoday #yaptaz

Nina Willburger @drnwillburger.bsky.social · 6mo ago

Apparently it's #WorldHippoDay! 🦛🦛 Let's celebrate with this #Egyptian carving of a Hippo, made 5.000 years ago from calcite. Hippopotami were associated with life, regeneration, and rebirth. On display at Ny Carlsberg Glyptotek 📷 me 🏺

NEW: Another NIH institute director hasn't been renewed — the director of NIAMS (arthritis, musculoskeletal and skin diseases institute). That leaves a whopping 15 of 27 institutes and centers without a permanent director.

With all their speed forward they may be a step backward in civilization—that is, in spiritual civilization. It may be that they will not add to the beauty of the world, nor to the life of men’s souls. - Booth Tarkington, 1918

Thrilled to share our new bioRxiv preprint led by Eloise Fadial (@efadial.bsky.social) 🥳🎉! Using PRDM16 cKO mice, hiPSC models, scRNA-seq & CUT&RUN, Eloise shows that PRDM16 is a key genetic and epigenetic regulator of knee chondrogenesis and chondrocyte identity. www.biorxiv.org/content/10.6...