Our newest study is now published. Here we show that GLP-1Rs are expressed in the lymphatic vasculature and enriched in LECs. And pharmacological activation by semaglutide enhances the pumping capacity of collectors. onlinelibrary.wiley.com/doi/10.1111/...

GLP‐1 Receptors Are Enriched in the Lymphatic Endothelium and Their Pharmacological Activation With Semaglutide Improves the Pumping Capacity of Lymphatic Vessels

Objectives Recent clinical studies have suggested that glucagon-like peptide-1 receptor (GLP-1R) agonists may be effective therapies to treat or reduce the risk of developing secondary lymphedema. I.....

onlinelibrary.wiley.com

We had a very productive day at the lab today, testing yet-another antibody for GLP-1R and a potential new marker for lymphatic endothelial cells… we also had our last King Cake of the season as a lab. We are on home stretch for Mardi Gras 2026!

We decided to start keeping track of the number of isolated lymphatics we successfully study. A strong 138 vessels in January… and not too shabby for a PI to run 52. @maryschulz.bsky.social is killing it, her and I hogged our 2 systems. I’m sure @keithkeane.bsky.social will have a strong February.

Our new preprint led by @maryschulz.bsky.social is now up. We show that semaglutide enhances the pumping capacity of collecting lymphatics. Our results support recent case reports suggesting beneficial effects of GLP-1R agonists in secondary lymphedema patients. www.biorxiv.org/content/10.6...

GLP-1R Agonism Directly Improves the Pumping Capacity of Murine Collecting Lymphatic Vessels

Background: Glucagon-like peptide-1 receptor (GLP-1R) agonists have recently been suggested as effective therapies to treat or reduce the risk of developing secondary lymphedema in patients with obesi...

biorxiv.org

Very proud of my student @maryschulz.bsky.social, who just received a NOA for her NIH-F31 project to study obesity-induced lymphatic dysfunction and explore novel therapeutics. Also, her recent paper (www.ahajournals.org/doi/10.1161/...), has been highlighted by an Editorial at ATVB. Congrats, Mary!

This beautiful work from the lab in Uppsala @taijamakinenlab.bs made it to the cover ! Happy to be part of it ! Congrats again to the first author Marle Kraft ! Stunning images

Nature Cardiovascular Research@natcardiovascres.nature.com · last yr.

❤️Our July issue is out❤️Discover an Angiopoietin-TIE2-dependent circuit promoting venous malformations, complex disease modelling in cardiac organoids, regulation of cardiac homeostasis by methyonil tRNA synthetase, and more! www.nature.com/natcardiovas...

scRNAseq of🐭collecting lymphatic vessels😎 Cell type-specific #LymphaticEndothelialCell vs peri-lymphatic myeloid cell contributions of TRPV4 in distinct stages of lymphatic contractile activity @maryschulz.bsky.social @jcastorena.bsky.social #ATVB 2025 www.ahajournals.org/doi/full/10....

Our lab had a great time learning and catching up with friends and colleagues at the Lymphatic Forum 2025. Congrats to @maryschulz.bsky.social and @keithkeane.bsky.social for receiving Travel Awards! Thank you @navbo.bsky.social, LE&RN, and @mcsociety.bsky.social for your support.

Excited to share our work on TRPV4 channels in lymphatic contractile function! www.ahajournals.org/doi/10.1161/... @jcastorena.bsky.social @ahajournals.bsky.social @ahascience.bsky.social

Regulation of Collecting Lymphatic Vessel Contractile Function by TRPV4 Channels | Arteriosclerosis, Thrombosis, and Vascular Biology

BACKGROUND: Dysregulation of TRPV4 (transient receptor potential vanilloid type 4)–mediated signaling has been associated with inflammation and tissue fibrosis, both of which are key features in the p...

ahajournals.org

Our study with Mike Davis showing that a component of the lymphatic contractile impairment in db/db mice is mediated by the activation of KATP channels in lymphatic muscle cells, in part due to chronic metabolic stress associated with elevated glucose, is now out. www.frontiersin.org/journals/phy...

Frontiers | Chronic metabolic stress impairs lymphatic contractility via activation of KATP channels in a mouse model of Type-2 diabetes

frontiersin.org

Our latest publication investigating the role of #palmitoylation in #lymphatic endothelial integrity. Big shoutout to Silvia Gonzalez-Nieves, Simon GUIGNARD and Thi Nguyen for their incredible work and dedication. 👏👏 www.sciencedirect.com/science/arti...

Insulin regulates lymphatic endothelial integrity via palmitoylation

Lipid metabolism plays a critical role in lymphatic endothelial cell (LEC) development and vessel maintenance. Altered lipid metabolism is associated …

sciencedirect.com

We are studying the biology of wound healing, using the smallest possible acute vascular injury we can imagine—a 5 um micropoint pulsed laser deformation of the endothelial cell plasma membrane. 🧪 #MedSky #EMSky #EMedSky #immunosky

🦕🦕 I’m happy this fun little book is finally out exploring how the physiology of the sauropod dino helped contribute to its dominance on earth for so long. However, I think I’ll stick to my day job 😁 🦕🦕