Pyrazinamide kills Mycobacterium tuberculosis via pH-driven weak-acid permeation and cytosolic acidification https://www.biorxiv.org/content/10.1101/2025.09.26.678883v1
J.-F. Cavalier
@jefcavalier.bsky.social
Research Director in Medicinal Biochemistry (mycobacteria, Mtb, M.abscessus, antibacterials, lipolytic enzyme inhibitors, medicinal chemistry, chemobiology) at LISM UMR7255 CNRS, Marseille https://tuberculosis-lbp.wixsite.com/tuberculosis-lbpteam/lbp-team
Great collaborative work driven by @pierresantucci.bsky.social which provides clear evidence on the mode of action of a well-known first-line anti-TB drug.
bioRxiv Microbiology@biorxiv-microbiol.bsky.social · 11mo agoPyrazinamide kills Mycobacterium tuberculosis via pH-driven weak-acid permeation and cytosolic acidification https://www.biorxiv.org/content/10.1101/2025.09.26.678883v1
Now out in Trends In Microbiology! Iron-sulfur proteins in mycobacteria: Master regulators of physiology and pathogenesis. Kudos to Valentin Berdal and Wassim Daher. Fantastic exchanges and discussions with leaders in the field: Béatrice Py, Sandrine Ollagnier de Choudens lnkd.in/dKGd2P8S
🚨 New review from our group! PhD student Amine Pochet dives into the use of cyclodextrins beyond drug delivery — as active agents against infectious diseases. @ciilofficiel.bsky.social @pasteurlille.bsky.social @inserm.fr @univlille.bsky.social www.sciencedirect.com/science/arti...
Beta-cyclodextrins in infectious disease therapy: A review of their function beyond simple drug carriers
Cyclodextrins (CDs) are cyclic oligosaccharides derived from starch through enzymatic conversion. Over the past decades, CDs and their derivatives (dC…
sciencedirect.com
🎉🎉🎉 Big congrats to Kien Lam UNG, recipient of the 2025 #ATIP-Avenir award! From decoding antibiotic resistance in M. abscessus to revealing plant hormone transporters in Nature, he is now launching a bold project on how sugar tweaks shape host–pathogen battles. Sweet science! 👏👏👏 shorturl.at/TJiHg
Kien Lam UNG is a recipient of the 2025 ATIP-Avenir program - IPBS-Toulouse
Kien Lam UNG obtained his PhD from the University of Montpellier, where he worked on[…]
shorturl.at
Today is a great day! Our article accepted on March 19, 2025 is published in Wiley mLife journal. Great collaborative work with JM Bolla's lab, @map-proteomique.bsky.social @canaanlab.bsky.social Céline Crauste from @ibmm-balard.bsky.social, and more... 👉 onlinelibrary.wiley.com/doi/10.1002/...
The polyamino‐isoprenyl enhancer NV716 enables the antibacterial activity of two families of multi‐target inhibitors against the ESKAPEE bacterium Enterobacter cloacae
Gram-negative bacteria are particularly prone to developing antimicrobial resistance (AMR), as evidenced by the WHO's ESKAPEE list of high-priority pathogens. One strategy that has increased is the u...
onlinelibrary.wiley.com
It is my real pleasure to share our ASAP article published in ACS Infect Dis. Another great collaboration with @pierresantucci.bsky.social @canaanlab.bsky.social @lkremer1.bsky.social @ibmm-balard.bsky.social @map-proteomique.bsky.social and more... Enjoy 😊 pubs.acs.org/doi/10.1021/...
Mapping of Mycobacterial Enzymes Involved in Triacylglycerol Accumulation as Intrabacterial Lipid Inclusions Using Activity-Based Multitarget Inhibitor Probes
Lipids play a critical role in the physiology, life cycle, and pathogenicity of mycobacteria. They largely participate in host–pathogen interactions and fulfill important functions ranging from cell w...
pubs.acs.org
⚠️ Breaking News ⚠️ Another great collaborative work with Victoria Magrioti, @canaanlab.bsky.social @map-proteomique.bsky.social now just published in @rscmedchem.rsc.org pubs.rsc.org/en/content/a...
Synthesis and Anti-mycobacterial Activity of Novel Medium-chain β-Lactone Derivatives: A Multi-Target Strategy to combat Mycobacterium abscessus
The constant emergence of drug-resistant mycobacteria, together with the lack of new antibiotics entering the market, has become a global public health problem that threatens the effective treatment o...
pubs.rsc.org
Happy to share our new article in Current Research in Microbial Sciences @canaanlab.bsky.social Nice work with Priscille Brodin, Aurelie Tasiemski, Celine Boidin-Wichlacz @pasteurlille.bsky.social, and more, on the use of antimicrobial peptides against Mtb. www.sciencedirect.com/science/arti...
Potency of all-D amino acid antimicrobial peptides derived from the bovine rumen microbiome on tuberculous and non-tuberculous mycobacteria
Despite the availability of antibiotics, tuberculosis (TB), caused by Mycobacterium tuberculosis, was once again declared the world's leading cause of…
sciencedirect.com
If you are interested in lipids in bacteria, check out this awesome new review written by my talented student Alyssa Carter, super postdoc Emily Woods and me. #chembio www.sciencedirect.com/science/arti...
Chemical strategies for targeting lipid pathways in bacterial pathogens
Microbial pathogens continue to plague human health and develop resistance to our current frontline treatments. Over the last few decades, there has b…
sciencedirect.com
"This looks bad"’ A Harvard infectious disease researcher is targeted in President Trump’s review
With Trump review, a Harvard infectious disease researcher stands to lose it all
"This looks bad"’ A Harvard infectious disease researcher is targeted in President Trump’s review
buff.ly
New paper from the Beatty Lab! 👇 Proteomic characterization of Mycobacterium tuberculosis subjected to carbon starvation | mSystems journals.asm.org/doi/10.1128/...
Proteomic characterization of Mycobacterium tuberculosis subjected to carbon starvation | mSystems
Tuberculosis is a devastating human disease that kills over 1.2 million people a year. This disease is caused by the bacterial pathogen Mycobacterium tuberculosis (Mtb). Mtb excels at surviving in the...
journals.asm.org
Congratulations to group leader @maxgg.bsky.social, who received a £3.4m @wellcometrust.bsky.social Discovery Award to study the effectiveness of antibiotics against tuberculosis. www.crick.ac.uk/news/2025-04...
£3.4m awarded to study effectiveness of antibiotics against TB
Crick Group Leader Max Gutierrez has received a £3.4 million Wellcome Discovery Award to investigate how differences in immune cells impact the effectiveness of antibiotics against tuberculosis.
crick.ac.uk
Thrilled to share the last work from the lab! Generating a mycobacterial strain lacking all T7SS and studying the contribution of ESX-3 and ESX-4 in M. abscessus pathogenesis. Great collab with E Tocheva and JL Herrmann. rdcu.be/d8uHH
Big Change in TB treatment recommendations. 6 months of RIPE (also called RHEZ) was once the only treatment in town for susceptible TB. Now there's an all oral FOUR months of: Rifapentine INH PZA Moxifloxacin t.co/8EHiWEhEk8
🔊 JOB ALERT! L'IPBS Toulouse recrute un personnel technique pour rejoindre l'équipe émergente "Biochimie et Biologie Structurale des Protéines Membranaires" dirigée par le Dr Kien Lam UNG @unglam.bsky.social à partir de février 2025. Voir l'offre et candidater : emploi.cnrs.fr/Offres/CDD/U...
Portail Emploi CNRS - Offre d'emploi - H/F - Technicien ou technicienne en biologie moléculaire et biochimie
emploi.cnrs.fr
After a BioRxiv preprint, here is the final published version of our article dealing with the ph-driven mode of action of salicylic acid derivatives @pierresantucci.bsky.social @canaanlab.bsky.social and more febs.onlinelibrary.wiley.com/doi/10.1002/...
FEBS Press
Salicylic acid (SA), its two iodinated analogues 5ISA and 3,5diISA, as well as the anti-inflammatory drug aspirin (ASP), are anti-TB drugs that disrupt the intrabacterial pH homeostasis of Mycobacter...
febs.onlinelibrary.wiley.com
Our last article dealing with Cyclipostin & Cyclophostins compounds to counteract macrolide-induced resistance in Mabscessus is out! Great collaborative work @lkremer1.bsky.social @canaanlab.bsky.social @pierresantucci.bsky.social @camoinluc.bsky.social jbiomedsci.biomedcentral.com/articles/10....
Cyclophostin and Cyclipostins analogues counteract macrolide-induced resistance mediated by erm(41) in Mycobacterium abscessus - Journal of Biomedical Science
Background Mycobacterium abscessus is an emerging pathogen causing severe pulmonary infections, particularly in individuals with underlying conditions, such as cystic fibrosis or chronic obstructive p...
jbiomedsci.biomedcentral.com
🚀💥🔥Happy to Share that Our Latest Story is Now Published in FEBS Letters! 💙💎💡 Have a look & find out about the new subset of Mycobacterial CRISPRi vectors we optimised for our community! 🦠🔦🔬💊 @cnrs.bsky.social @addgene.bsky.social 👇👇👇 febs.onlinelibrary.wiley.com/doi/full/10....
FEBS Press
Genetic engineering and quantitative fluorescence imaging are key approaches in modern biology research. In this research letter, we report the development and the validation of a new subset of Esche...
febs.onlinelibrary.wiley.com
A new preprint from Matthew Bogyo. They developed and screened cyclic peptide libraries using mRNA display with a genetically encoded oxadiazolone (Ox) electrophile that was previously shown to potently and covalently inhibit multiple Fph enzymes in S. aureus. www.biorxiv.org/content/10.1...
An mRNA Display Approach for Covalent Targeting of a Staphylococcus aureus Virulence Factor
Staphylococcus aureus ( S. aureus ) is an opportunistic human pathogen that causes over one million deaths around the world each year. We recently identified a family of serine hydrolases termed fluor...
biorxiv.org
I made a Starter Pack for the Myco & TB community. Hope to find more good friends here on Bluesky to keep in touch about mycobacterial infections. Please join and repost! go.bsky.app/3nwpcVV