Jeff Lipshultz
@jeflip.bsky.social
Assistant Professor of Chemistry, PI of @LipshultzSBU.bsky.social, @stonybrooku.bsky.social lipshultz.group
🚨Paper ALERT🚨 Happy to share our News and Views 📰“Hydrogen atom transfer with neutral acridines” from our Postdoc Timothy D. ! Check it out here: www.nature.com/articles/s41...
Hydrogen atom transfer with neutral acridines
Nature Catalysis - Simple organic molecules that can directly activate carbon–hydrogen bonds when photoexcited are effectively limited to carbonyls. Now, neutral acridines,...
nature.com
The reaction creates molecular complexity quickly and constructs scaffolds not previously imagined from alkyl halides: #chemsky 🧪
Chemists get twice the reactivity from a single substitution handle
New reaction forms disubstituted products, thanks to a styrene radical cation intermediate
cen.acs.org
started doing this with my group in 2023. a bit smaller.... now we have so many friends! weather was MUCH better this year....
Lipshultz Group@lipshultzsbu.bsky.social · 4w agoa successful beach day (most) of the organic chemistry groups along with a PhDs vs Candidates volleyball match! (a few injuries, no deaths) @GustafsonLab @jillalty.bsky.social @barneygrubbs.bsky.social @qjbruch.bsky.social Prof. Katherine Aubrecht and Prof. Matthew Parkers Group
a successful beach day (most) of the organic chemistry groups along with a PhDs vs Candidates volleyball match! (a few injuries, no deaths) @GustafsonLab @jillalty.bsky.social @barneygrubbs.bsky.social @qjbruch.bsky.social Prof. Katherine Aubrecht and Prof. Matthew Parkers Group
Out First Release in @science.org for chemsky today, the Hirschi and Musacchio groups collaborate on a radical 2-for-1 substitution of alkyl halides www.science.org/doi/10.1126/...
Vicinal disubstitution of alkyl C–X synthons via alkene radical cation generation
In organic chemistry, functionalization of two adjacent carbons often starts from alkenes or already disubstituted precursors. Herein, we report an exergonic activation mode that directly generates al...
science.org
Exclusive: The National Science Foundation is trimming this year’s budgets for hundreds of its traditional basic science programs by roughly 20% to 30%, even though its overall budget is down just 3%. https://scim.ag/4xY2KCm
Exclusive: NSF slashes research programs to support new tech initiative, insiders say
Unexpected shift in funds has meant sharp drop in grants this fiscal year
science.org
📣 Calling all chemists/catalysis peeps! 📖 Ever considered working in scientific publishing as an editor? ✅ If yes, @natcatal.nature.com is hiring! 📍Shanghai, Beijing, Milan or Pune 📅 Deadline: July 12 🙏 Reposts appreciated 🧪 #Chemsky springernature.wd3.myworkdayjobs.com/SpringerNatu...
Associate or Senior Editor, Nature Catalysis
Title: Associate or Senior Editor, Nature Catalysis Locations: Shanghai, Beijing, Milan and Pune – hybrid working model Application Deadline: July 12, 2026 (Candidates will be considered as they apply...
springernature.wd3.myworkdayjobs.com
I wrote a quick post on my much neglected Substack about how attending seminars is hard when also having to manage school pickups. open.substack.com/pub/nealmank...
Departmental seminars could be more family friendly
Today I want to reflect on departmental seminars, which are getting harder for me to attend for work/life balance reasons I’ll explain below.
open.substack.com
Congrats to Ashley, leaving for the summer, starting the Boehringer Ingelheim 2026 Student Internship Program in Ridgefield, CT
Excited to share our new ChemRxiv preprint: “Leveraging Conformational Control of Neratinib’s C–N Axes to Enhance HER4 Selectivity in Ovarian Cancer” Read here: doi.org/10.26434/che...
Leveraging Conformational Control of Neratinib’s C–N Axes to Enhance HER4 selectivity in Ovarian Cancer | ChemRxiv
Diarylamines are among the most privileged scaffolds in drug discovery, with a myriad of examples in the clinic including the multi-kinase inhibitor neratinib which possesses indications towards HER2 overexpressed breast cancers. Diarylamines possess a ...
doi.org
Really grateful for the support from the community about LIPCS as we expand beyond the SBU-BNL Photochem Supergroup, and excited for the future, with support from my NSF CAREER award!
Lipshultz Group@lipshultzsbu.bsky.social · 3mo agoA successful wrap to the first annual Long Island Photochemistry Symposium! A great deal of posters, speakers, and a wonderful keynote lecture from Stony Brook’s Ben Levine!
Truly honored to have been awarded an NSF CAREER for our Ti photocatalysis research, as well as development/expansion of our efforts in photochemistry education and community-building. Grateful for the support for basic science research on sustainable catalysis!
Lipshultz Group@lipshultzsbu.bsky.social · 3mo agoThrilled to share great news! The group has received an NSF CAREER award! This grant will support our efforts in the development of rationally-designed photoactive Ti catalysts, as we seek to develop new synthetic transformations operating in catalyst-controlled paradigms!
MAJOR UPDATE: I found the best free restaurant bread in the United States www.theatlantic.com/magazine/202...
I Found It: The Best Free Restaurant Bread in America
Thirteen thousand miles. Infinite contenders. One beautiful loaf.
theatlantic.com
Caity Weaver@caity.bsky.social · 10mo agoIMPORTANT QUESTION: What is the best free restaurant bread in the United States? (ANY restaurant is eligible, but the bread must be free provided free to *every* table.)
In @science.org for chemsky this week, @tehshik.bsky.social teams up with @chemguyeli.bsky.social to showcase the versatile advantages of pairing a pybox ligand with a carbazole chromophore in one molecular catalyst www.science.org/doi/10.1126/...
Modular enantioselective photocatalysts from privileged pybox scaffolds
Modern organic synthesis relies upon the availability of chiral catalysts to control the stereochemistry of bond-forming reactions. Several families of chiral catalysts have become recognized as “privileged” structures because of their notable generality ...
science.org
a man in a leather jacket and tie is saying cool cool cool cool cool cool cool
ALT: a man in a leather jacket and tie is saying cool cool cool cool cool cool cool
media.tenor.com
Aaron Clauset@aaronclauset.bsky.social · 4mo agotl;dr: NIH is running at about 60% of pre-Trump levels and NSF is running at about 20% of pre-Trump levels of funding-outlays (some directorates far below even that). Utterly catastrophic. An unforced disaster for U.S. society, and the world
$2.45 billion NIH grant cuts and ~2300 terminated active research grants were DOGE'd in early 2025 Who were most affected? www.pnas.org/doi/full/10.... Early career and women researchers
The data is in: the NIH goalposts have shifted. What were once almost certain fundable scores have become coin flips and what used to be likely grants have become aspirational, leading to fewer awards. Another manifestation of how HHS policies have led to fewer awards and less science.
Our department is looking for a PRODiG+ fellow – the appointment is two years, followed by conversion to a tenure-track assistant professor at the conclusion of the fellowship. A unique opportunity! apply.interfolio.com/178732
Apply - Interfolio {{$ctrl.$state.data.pageTitle}} - Apply - Interfolio
apply.interfolio.com
Wow, great initiative!! Grant churn will only increase, so having funds to keep competitive projects running in the meantime is huge. record.umich.edu/articles/u-m...
U-M announces new research funding program for federally reviewed proposals | The University Record
record.umich.edu
Maybe I am just missing it... does the new Chemrxiv website have RSS feeds? The organic specific RSS feed we've used is dead...
What I love about that six word Hemingway story, "For sale: baby shoes, never worn" is that in those few words we instantly grasp the sadness of what it is trying to tell us: the baby was so freakishly massive when it was born that it could never wear the shoes its parents had bought for it.
Really excited to shared this work! Congrats especially to Zilu and Yetong, who worked through the two divergent mechanistic paradigms to explore this system thoroughly. And a very fruitful collaboration with Dr. Arshad Mehmood in the Levine Group!
Lipshultz Group@lipshultzsbu.bsky.social · 6mo ago🎉 Thrilled to share our latest work on Ti-LMCT photocatalysis, out now in @jacs.acspublications.org. We show how Ti-catalysts bearing electronically-differentiated ligands can be leveraged for divergent reaction pathways from the LMCT excited state. Read it here: pubs.acs.org/doi/10.1021/....
🎉 Thrilled to share our latest work on Ti-LMCT photocatalysis, out now in @jacs.acspublications.org. We show how Ti-catalysts bearing electronically-differentiated ligands can be leveraged for divergent reaction pathways from the LMCT excited state. Read it here: pubs.acs.org/doi/10.1021/....
Leveraging Divergent Ligand-to-Metal Charge-Transfer Excited State Pathways for Catalyst Control over Alkoxyl Radical Reactivity
Ligand-to-metal charge-transfer (LMCT) excitation has emerged in recent years as a powerful modality in organic synthesis, namely for the generation of heteroatom-centered radicals through formal metal–ligand bond homolysis from the LMCT excited state. However, the exploitation of alternative LMCT excited state processes has been extremely limited. Here, we describe a general strategy for tuning the reaction course from LMCT excited states of titanium alkoxides. This reactivity paradigm has been exploited for tandem β-scission/Giese addition reactions of both scission-amenable and scission-recalcitrant alcohols under divergent reaction pathways of metal–ligand bond homolysis and excited state β-scission through judicious choice of electronically tuned Ti catalysts. Through intramolecular competition studies, catalyst-controlled scission is shown to facilitate a rate enhancement of up to 103-fold over the intrinsic scission of free alkoxyl radicals, highlighting the impact of accessing the excited state scission paradigm. Computations support the relevance of a scission-promoting LMCT excited state with stereoelectronically aligned alkoxyl radical cation character to enable direct, selective β-scission.
pubs.acs.org
Five classes I took in college. The Atomic Bomb in History and Culture Madness and Medicine The Vikings and the Nordic Heroic Tradition Justice Introduction to Scientific Computing
Chemjobber@chemjobber.bsky.social · 6mo agoTell me five classes you took in college. Molecular Biology of HIV History of the Civil War Organic Chemistry (2.5X, lol) Science Writing Physical Chemistry (woof)
I wrote this song on Saturday, recorded it yesterday and released it to you today in response to the state terror being visited on the city of Minneapolis. It’s dedicated to the people of Minneapolis, our innocent immigrant neighbors and in memory of Alex Pretti and Renee Good. Stay free
Bruce Springsteen - Streets Of Minneapolis (Official Audio)
YouTube video by Bruce Springsteen
youtu.be
