Reminder: new #InflammaZoom free Webinar is today at 2 pm BST with James Murphy @pseudokinase.bsky.social from WEHI and Jonathan Maelfait from VIB Ghent. Register via Abcam link below. See you soon!

JelenaBezbradicaLab@jelenalab.bsky.social · 10mo ago

#InflammaZoom free Webinar is back on Monday October 20th! With James Murphy (WEHI, Melbourne, Australia) @pseudokinase.bsky.social and Jonathan Maelfait (VIB-UGent, Ghent, Belgium) Register now: bit.ly/4iXGqjw

#InflammaZoom free Webinar is back on Monday October 20th! With James Murphy (WEHI, Melbourne, Australia) @pseudokinase.bsky.social and Jonathan Maelfait (VIB-UGent, Ghent, Belgium) Register now: bit.ly/4iXGqjw

Congratulations to newly minted Dr. Esther L. Jones @estherlj.bsky.social on her successful DPhil viva! A great collaborative project between the L. Dustin and Jelena Bezbradica @jelenalab.bsky.social labs. Many thanks to examiners Irina Udalova @udalovalab.bsky.social and Menna Clatworthy.

Excited to share that our paper examining how GM-CSF potentiates cytokine responses in human monocytes during bacterial infection is now online at the @asm.org journal Infection & Immunity! Congrats to @vvazquez.bsky.social, @mikelhaggadone.bsky.social, & co-authors! journals.asm.org/doi/full/10....

GM-CSF engages multiple signaling pathways to enhance pro-inflammatory cytokine responses in human monocytes during Legionella infection | Infection and Immunity

Respiratory infections are a leading cause of morbidity and mortality worldwide, as evidenced by the COVID-19 and tuberculosis pandemics (1, 2). More than 4 million people die annually due to respirat...

journals.asm.org

Dr. Sunny Shin@sunnyshinlab.bsky.social · 2y ago

Happy to share our latest preprint from 1st author & PhD student @vvazquez.bsky.social examining how GM-CSF potentiates cytokine responses in human monocytes during bacterial infection! Congrats to Victor, his undergrad mentees Allyson Lu & Madison Dresler, & postdoc @mikelhaggadone.bsky.social! 🧪

Thrilled to share our @elife.bsky.social paper "Inflammasomes primarily restrict cytosolic Salmonella replication within human macrophages" by 1st author Dr. @marisaegan.bsky.social (@cambupenn.bsky.social alum, now faculty @swarthmorecollege.bsky.social)! elifesciences.org/articles/90107 🧵(1/n)

Elegant work by @jkagan1.bsky.social and team on identifying how innate immune receptor Caspase 11 recognises molecular patterns in LPS and self lipids.

Jonathan Kagan@jkagan1.bsky.social · last yr.

What do Pablo Picasso and Charles Janeway have in common? Both were interested in patterns of life. Janeway was focused on pathogen associated molecular patterns (PAMPs) that are detected by our immune system. But what are these patterns he refers to?

#InterferonFriendOrFoe?! Klein @kahlenberglab.bsky.social &co show Science Immunology that UV drives mitochondrial Z-DNA to induce type I & III IFNs in keratinocytes. IFN-I upregulates ZBP1 that binds Z-DNA activating cGAS-STING to boost IFNs, photosensitivity & inflammation in #Lupus skin!

Epidermal ZBP1 stabilizes mitochondrial Z-DNA to drive UV-induced IFN signaling in autoimmune photosensitivity

ZBP1 and mitochondrial Z-DNA drive autoimmune photosensitivity via cGAS-STING activation.

science.org

The loss of TBK1, or both TBK1 and the related kinase IKKε, results in uncontrolled cell death–driven inflammation. We show that TBK1/IKKε prevent premature cell death by limiting the activity of multiple death pathways in myeloid cells. www.science.org/doi/10.1126/...

TBK1 and IKKε prevent premature cell death by limiting the activity of both RIPK1 and NLRP3 death pathways

TBK1 and IKKe prevent premature cell death by limiting the activity of multiple death pathways in myeloid cells.

science.org

We are excited to announce the 2nd Symposium on the Immunobiology of Pattern Recognition Receptors, Oct 1-2 2025, Lausanne, Switzerland. Registrations open March 1 - Attendance limited to 150 participants. More info: wp.unil.ch/immunobiolog... #ImmunoSky

Two weeks to go until the application deadline for ILESLA. If you or anyone you know would benefit from full funding to carry out a PhD in Life and/or Environmental Science please visit/refer to our website page iles.web.ox.ac.uk/how-apply where you can see open day videos and get full guidance.

How to Apply and Funding

iles.web.ox.ac.uk

Absolutely fantastic work by Vivian Lau and @gerardlab.bsky.social on IFNy-related tumour escape! Must-read for all tumour immunologists! 💯

Gerard Lab@gerardlab.bsky.social · 2y ago

Tumours escape the immune system by mutating to decrease their immunogenicity. In this study, now in @natcomms.bsky.social, we described that immune cells can adapt to IFNg-driven escape, enhancing their fitness and thereby counteracting tumour escape www.nature.com/articles/s41...

Ok, let's start here on @bsky.app by reposting this truly outstanding paper by @lozanzi.bsky.social and colleagues!

Ivan Zanoni@lozanzi.bsky.social · 2y ago

#EveryCellIsAnImmuneCell!💥Thrilled for the final version of our paper @cp-cell.bsky.social! We show that type III #interferons control ZBP1 activation driving gasdermin C cleavage & delaying gut repair by inducing #pyroptosis in intestinal epithelial cells! 1/n www.cell.com/cell/abstrac...