Terrific work from @jelenalab.bsky.social and Fabian Fischer on controlling cell death. Fantastic to see this out!

JelenaBezbradicaLab@jelenalab.bsky.social · last yr.

The loss of TBK1, or both TBK1 and the related kinase IKKε, results in uncontrolled cell death–driven inflammation. We show that TBK1/IKKε prevent premature cell death by limiting the activity of multiple death pathways in myeloid cells. www.science.org/doi/10.1126/...

I love me some Bernie Sanders

Super proud of my friend Sabrin @sabtahri.bsky.social, whose final (and terrific) PhD work came out today in #Blood (in collab with group of Niels vd Donk) It demonstrates an association between BM CD16+ NK cells and response to dara! #hemesky #hematology #myeloma doi.org/10.1182/bloo...

Reese Witherspoon became a billionaire and people are cheering and congratulating her on being a hugely talented business woman. I feel people do not realise that money is a limited thing. Billionaires (skilled or not, it doesn’t matter) are hoarding the resource.

What I find so brilliant about the haematopoiesis is that it takes place in a piece of tissue (bone) that already fulfils another role (holding up the meat sack). Human design being space-efficient, ain’t it something

When I said 2025 was gonna be my year 😭 Can I restart? I wasn’t ready

Just learned that US school libraries have banned Anne Frank’s diary, for the reason being she briefly discusses crushing on a girl. Anne Frank’s diary! Banned!

Hematologists! I need help! What is the unmarked population? Lin-cKit+Sca1-CD16/32+CD34- in mouse bone marrow! #hematology #hemesky

Getting a bit tired of the inflation of importance of the physician-scientist. And I say that as someone who went to med school once upon a time. Acting like they’re the most important being in research sells basic biologists, far stronger in bench lab skills, way short.

Landed my 2nd ever grant, hurray! 🥳

Eurostar really getting on my last nerve and it’s only Jan 5th

Absolutely fantastic work by Vivian Lau and @gerardlab.bsky.social on IFNy-related tumour escape! Must-read for all tumour immunologists! 💯

Gerard Lab@gerardlab.bsky.social · 2y ago

Tumours escape the immune system by mutating to decrease their immunogenicity. In this study, now in @natcomms.bsky.social, we described that immune cells can adapt to IFNg-driven escape, enhancing their fitness and thereby counteracting tumour escape www.nature.com/articles/s41...

#EveryCellIsAnImmuneCell!💥Thrilled for the final version of our paper @cp-cell.bsky.social! We show that type III #interferons control ZBP1 activation driving gasdermin C cleavage & delaying gut repair by inducing #pyroptosis in intestinal epithelial cells! 1/n www.cell.com/cell/abstrac...

Type III interferons induce pyroptosis in gut epithelial cells and impair mucosal repair

Intestinal damage following colitis or irradiation induces type III interferons (IFNs), which delay the healing of the intestinal epithelium. IFN-λ directs the sensing of Z-form nucleic acids generated during gut injury and repair, triggering cell death and altering healthy epithelial regeneration.

cell.com

For anyone who may need these over Xmas…just in case

Although still in 'First Edition' style, I am happy to finally share our latest article on DNMT3A double mutant AML. Hope to be able to share the way-easier-to-read print version of the paper soon! (1/2) #hemesky ashpublications.org/bloodadvance...

Double mutant DNMT3A AML: a unique subtype experiencing increased DNA damage and poor prognosis

Key Points. 1. Wildtype DNMT3A enhances TDG-mediated repair, whereas mutant DNMT3A impairs this process.2. Double mutant DNMT3A AML exhibits increased DNA

ashpublications.org

Now in press, excellent paper by @zkellermayer.bsky.social where he shows that in the myeloma 5TGM1 model activation of NK cells, ILC1 and CD8+ T cells is lost upon disease progression! 👀 Awesome work, happy to have contributed #mmsm onlinelibrary.wiley.com/doi/full/10....

Interferon gamma‐mediated prevention of tumor progression in a mouse model of multiple myeloma

Malignant plasma cells in multiple myeloma patients reside in the bone marrow and continuously interact with local immune cells. Progression and therapy response are influenced by this immune environ...

onlinelibrary.wiley.com

Things to love about living in Oxford:

What if all PhDs just stopped defending and started attacking?

Officially dr. de Jong 🥂 Last Friday I finally defended my thesis and obtained my PhD degree cum laude. A big thank you to my supervisor Tom Cupedo, my paranymphs Cathelijne Fokkema, Sabrin Tahri and Natalie Papazian, and the opposition committee 🙌🏻

Share and help fill this one up! Suggestions via comments or DM! #stroma #fibroblast #MSC go.bsky.app/KPJMU4

Still trying to build a stromal biology starter pack! #stroma #fibroblast Let me know if you or other stromal biologists have joined bsky so I can add you!

Madelon de Jong@mdejong.bsky.social · 2y ago

I’ve made a starter back for #stromalcell #fibroblast enthusiasts! 🧫 It’s still very small as it seems many of our community haven’t made the move here yet and/or I can’t find them! Please reach out if you want to be added 🙌🏻 go.bsky.app/KPJMU4

go.bsky.app/221DCXf

#LocationLocationLocation & #EveryCellIsAnImmuneCell!! Check out the final version just out today of our Trends in Immunology review on the regionalization of the immune response along the respiratory tract!! dlvr.it/TG3Qzc

Regional specialization within the mammalian respiratory immune system

The respiratory tract is exposed to infection from inhaled pathogens, including viruses, bacteria, and fungi. So far, a comprehensive assessment that integrates common and distinct aspects of the immu...

dlvr.it

I got glasses for astigmatism and I think my prescription is slightly off as I can now see my cat’s retina reflections from certain angles 🙃 Makes me feel very eye-doctory though! #eyeSky

Maybe my parents would finally understand what I do

Bérénice A. Benayoun, PhD@bbparis1984.bsky.social · 2y ago

Hear me out - a show about a science department following PIs, postdocs and grad students👩‍🎓👨‍🎓. I think it would be at least as entertaining as all these medical shows (i know there would be a lot of comedy material 😅). (TBBT does not count; the Chair was awesome but sci academia has more shenanigans!)

I've also made a feed with that collects posts from everyone in this starter pack bsky.app/profile/dpas... . I'm thinking it'd be most useful if there perhaps is also a keyword attached (which shouldn't be too long because char limit) #juniorlifescience perhaps?

Dorien Pastoors@dpastoors.bsky.social · 2y ago

I am really enjoying the surge of people to bluesky but still kind of missing the VERY early career group of people! (Aging in academia is a funny thing) - I went ahead and made this starter pack go.bsky.app/Jq8YaQM - if you would like to be removed/added please let me know

Wonderful to see the #immunology community growing here. The first starter pack is full (they cap at 150), so I created a second one. Let me know if you'd like to be added go.bsky.app/PY5tCas go.bsky.app/FmERUoD

My PhD on bone marrow inflammation in #myeloma has finally come to an end! Thesis written and distributed and I will be defending a week from now! Very ready to go ahead full throttle on a new chapter in my career

Are all Dutch people a bit iffy about using ‘skeet’ to indicate posting on here or am I the only toddler around? 🙊🇳🇱

For those with an 'invalid handle' handle