Systemic and cardiac pathology induced by a clinically relevant USP8 activating mutation Read and share the Research Article by Tamara González-Costa and colleagues @jldelapompa-cnic.bsky.social for free: doi.org/10.1242/dmm....

Mouse with USP: Mouse model of Cushing's disease which bears human mutated USP gene recapitulates a range of abnormalities - incl. corneal (depicted) 📷 Tamara González-Costa et al @jldelapompa-cnic.bsky.social CNIC Madrid in @dmmjournal.bsky.social ➡️ bpod.org.uk/archive/2026...

4D Nucleome special issue of Science, featuring our paper "Dose-dependent sensitivity of human three-dimensional chromatin to a heart disease–linked transcription factor", led by Zoe Grant in my lab and Zhuzhen Kuang in Katie Pollard's lab @gladstoneinst.bsky.social www.science.org/toc/science/...

We have to bid @tonyfirulli.bsky.social farewell, as we do in fall to swifts! Likewise, we truly wish to see him after a couple of seasons. He has been an awesome labmate these 7 weeks, incredibly generous with his time, suggestions, and the way he enjoys science. Thank you so much, Tony!

I believe that in order to take some small step forward, the word “bird” should be replaced with “saur” in all common names. Mockingsaur. Secretarysaur. Red-winged blacksaur. HUMMINGSAUR

Good morning, y'all! We had another meeting of the placheart.org project (funded by Leducq Foundation), this time in Bristol!! Wonderfully hosted by Fraser's lab from the @bristoluni.bsky.social , we enjoyed beautiful weather, great science and some birding.

Good morning, y'all! We had another meetingof the placheart.org project (funded by Leducq Foundation), this time in Bristol!! Wonderfully hosted by Fraser's lab from the @bristoluni.bsky.social , we enjoyed beautiful weather, great science and some birding.

cross-posting for the organizers: "Don't miss out on this year's Weinstein Conference on Cardiovascular Development & Regeneration, in New York, May 6-8! weinstein-conference.com Apply for a travel award ($500-1,000) by April 10th by filling out the following form: docs.google.com/forms/d/e/1F...

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Join leading scientists in New York for the 2026 Weinstein Cardiovascular Development & Regeneration Conference — an international meeting showcasing breakthroughs in heart development, congenital heart disease, and cardiac regeneration.

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Our collaboration with the team of JL de la Pompa is finally out! 🥳🥳

De la Pompa Lab@jldelapompa-cnic.bsky.social · 8mo ago

Great, great news! We just published a paper!🥳 Alba Pau Navalón, other members of our lab and @henarcuervo.bsky.social identified endothelial USP8 as a key regulator of angiogenesis across developmental and postnatal context. Even more interesting details in Angiogenesis (doi.org/10.1007/s104...)!

Great, great news! We just published a paper!🥳 Alba Pau Navalón, other members of our lab and @henarcuervo.bsky.social identified endothelial USP8 as a key regulator of angiogenesis across developmental and postnatal context. Even more interesting details in Angiogenesis (doi.org/10.1007/s104...)!

We hope that (almost) everyone has a happy 2026. Right before holidays we held an great lab retreat in Cercedilla, with a beautiful trek in @pnsierraguadarrama.bsky.social, lots of fun, science and, of course, birds! Thanks to @fundlacaixa (not in BSky, sorry) and the CARDIOGENOMICS project!

Well, well! While some of us were struggling with the (scientific) hangover from granada, Carlos Relaño Rupérez was showing (off) his bits and bytes and lines of code in the city with the best tap water in the world, beautiful as well, historic as well: Madrid.

Look how cool, Felix Trogisch and Joerg Heineke highlight our decorin paper academic.oup.com/cardiovascre... in their last editorial in Cardiovascular Research academic.oup.com/cardiovascre.... I love the title 💃🏻💃🏻 Decorin expression is increased by ageing and contributes to inflammation and leakage.

Ageing-associated endothelial decorin induction and the impact of non-glycanated decorin on cardiac inflammation

AbstractAims. Cardiovascular disease is the leading cause of death in the European Union and ageing is one of its major risk factors resulting in the progr

academic.oup.com

Some briefing from the last days in Granada: On thursday, Brenda Flores Garza, Tamara González Costa, and Marcos Siguero Álvarez (thanks, @biologists.bsky.social ) presented their posters. What is more: Alba Pau won the prize for the best poster!! Well done, flamingo!

Hi, there! After some rest from last week's social agenda, we bring you the picture we took with our placheart.org project (funded by Leducq Foundation) colleagues at CNIC. Of course, with Fraser’s, Kahn’s, Karumanchi’s, Hemberger’s, @aranylab.bsky.social and @stainierlab.bsky.social labs.

@navbo.bsky.social 2025 starts this Sunday and the great @leahvanicek.bsky.social will be flying the colours of the @instcardregffm.bsky.social. She will present her work on HFpEF and microvascular cells. Watch out for funky pericyte stuff 💃🏻🤘🏻🫀 @cpi-exstra.bsky.social @dzhk.de @sfb1531.bsky.social

Tamara González Costa also took the central stage, but in the Alhambra (damn, Carlos V). Awesome guided visit to the beautiful andalusi fortress/palace/medina. Lots of flowers, scientists and birds, such as the eurasian blackcap. Now back to the meeting!

Today we are having the second ICDAR day, with a first session including the great Maria Teresa Soto Navarrete and her Actc1 model of HCM. She sang her presentation as beautifully as robins do in october dawns in Madrid.

My first post in Bluesky: Mesodermal lineage tracing (green) in embryonic mouse hearts. Tg(Mef2c-AHF-Cre) and Mesp1-cre lines were used above and below, respectively, to trace mesodermal cells (green) at E9.5 (left) and E14.5 (right) stages. #science #heart #development #artwork #biology

Now it is turn for two of our PhD candidates, Alba Pau Navalón and Violeta Sebastián Serrano, to defend their work during the first poster session. Come around posters 1 and 3, if you happen to be in Granada.

Just arrived to Granada to enjoy ICDAR conference. Anxious to enjoy this beautiful city with this beautiful company and the beatiful science this meeting always brings.

Great first day of the #Leducq Foundation's PlacHeart.org meeting, this time hosted at #CNIC. Pictures coming soon, but since we had long travellers, we'll share some Sandhill cranes to honor their rare trip to Europe.

On Friday we held a dissemination activity as part of the European Researchers' Night. We showed to a curious and participative audience why what we do is important and how we do it (and they could take a souvenir with them!). We will repeat the show in November for the Science Week, so stay tuned!

This Saturday we had our peregrine falcons zooming through Madrid in the Carrera del Corazón organized by @cuidarcorazon.bsky.social to promote cardiovascular health as part of the CNIC team. Carlos, Tamara and José Luis enjoyed the first sunny weekend morning in fall while fulfilling the 10 Km

This week we had @gluxan.bsky.social and @leahvanicek.bsky.social from @instcardregffm.bsky.social . They flew from Frankfurt am Main to Madrid as red kites do around this time each year, and brought great science under their wings! Looking forward to learning about how your projects develop!

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Watch out: Early-bird deadline approaching for ICDAR meeting eventos.ujaen.es/126123/detai... in (the wonderful city of) Granada, Andalucía!

Feto-placental blood vessel development In this Review, Jacinta Kalisch-Smith @jkalism.bsky.social gives an overview of placental vascular development and pathologies in mice and humans and highlights key remaining questions in the field: doi.org/10.1242/dev....

By the way... Last week we sent an emissary (José Luis) to @weinsteinconf.bsky.social at Milwaukee. He took good notes and briefed us about the great talks and posters presented there.