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Anne-Marie Malfait

@jointsintheworld.bsky.social

for the Chicago Center on Musculoskeletal Pain (C-COMP) please see https://mskpain.center

31 Posts300 Follower154 Folgt
Nature Reviews Rheumatology@natrevrheum.nature.com · last yr.

✨June Issue✨| Targeting osteoarthritis where it hurts: the osteochondral junction This News & Views article discusses targeting neurovascular growth at the osteochondral junction as a therapeutic approach for osteoarthritis. @jointsintheworld.bsky.social bit.ly/4kiDfo3 #Rheumsky #Medsky

Targeting osteoarthritis where it hurts: the osteochondral junction - Nature Reviews Rheumatology

In joints with osteoarthritis, angiogenesis and neuronal growth occur at the osteochondral junction, a process that can contribute to structural joint damage and pain. Targeting this neurovascularizat...

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PAIN@painthejournal.bsky.social · last yr.

O’Brien et al. find that visual exposure to green light reduced joint pain in osteoarthritic rats independent of nociceptor activity. Analgesic endolipids were upregulated, suggesting involvement of the endocannabinoid system. Learn more in #PAIN bit.ly/3S2xpe3

19 May 2025
Anne-Marie Malfait@jointsintheworld.bsky.social · last yr.

Join us for our quarterly C-COMP journal club, featuring this exciting new paper by the team of @kelseyhcollins.bsky.social and @farsh-g.bsky.social Monday May 12th 10 am CST- ask us how to register! www.science.org/doi/full/10....

Adipose-derived leptin and complement factor D mediate osteoarthritis severity and pain

Osteoarthritis and knee joint pain are driven by systemic leptin and complement factor D secreted by adipose tissue.

science.org

Nature Reviews Rheumatology@natrevrheum.nature.com · last yr.

ICYMI: New content online:

Current challenges in understanding the epidemiology of calcium pyrophosphate crystal deposition

Nature Reviews Rheumatology, Published online: 17 April 2025; doi:10.1038/s41584-025-01256-3Calcium pyrophosphate deposition (CPPD) disease is secondary to the pathological accumulation of calcium pyrophosphate (CPP) crystals inside joints and involves acute or chronic inflammatory arthritis. Epidemiological research on CPPD has been slow despite the suspected high prevalence of this condition. Here we highlight key challenges in CPPD imaging, diagnosis and nomenclature that need to be addressed for epidemiological research to progress at a faster pace.

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Ted Price@tedpricethepainguy.bsky.social · last yr.

This is what’s at stake. My lab is full of young brilliant scientists who deserve the chance to make a difference in the world. Shutting them out is the dumbest move we can make. We need to rescue American science from these monsters.

Prasad Jallepalli, MD, PhD@prasad.bsky.social · last yr.

www.nytimes.com/2025/04/03/o... Really important piece to share widely. Too many Americans don’t know how severe a threat this Administration poses to our scientific infrastructure, global leadership, and health security

Boston University Chobanian & Avedisian School of Medicine @bumedicine.bsky.social · last yr.

New study by BU’s Dr. Jean Liew finds people with lower bone mineral density in the subchondral bone of the knee are more likely to experience knee pain, suggesting that the structure of bone plays a key role in osteoarthritis pain: bit.ly/4hbzOx8

Relationship between knee pain and depth-specific measures of proximal tibial subchondral bone density

Altered subchondral bone mineral density (BMD) may be a possible contributor to osteoarthritis (OA) pain. We evaluated the relation of compartment-spe…

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Ted Price@tedpricethepainguy.bsky.social · last yr.

These are shocking graphs. We are being strangled by our own government. It is notable that the consistent message has been that us researchers are somehow doing a disservice to the American people, sitting on this money getting fat from the largesse. In fact, we are focused on discovery and cures.

Dan Diamond@ddiamond.bsky.social · last yr.

See this chart for one stark example: NIH funding has dramatically slowed down. Grant awards are down *$3 billion* so far, compared to same time period last year I asked the White House to explain. “This is not a researcher entitlement program,” said an official, defending their new approach.

ACR Journals@acr-journals.bsky.social · last yr.

Placebo effect influenced by active treatment category and changes over time in knee osteoarthritis trials doi.org/10.1002/acr.... Patient-reported treatment goals in psoriatic arthritis doi.org/10.1002/acr....

Placebo Effect Sizes are Larger in Clinical Trials of Knee Osteoarthritis using Intra‐Articular Injections of Biologic Agents

Objective Patients with knee osteoarthritis (KOA) rely on symptomatic treatments where up to 75% of the pain reduction can be attributed to the placebo effect. This effect may vary based on treatmen.....

doi.org

Margaret A. McNulty@drmamcnulty.bsky.social · last yr.

If anyone in Indiana’s 5th Congressional district has the time, please attend this town hall and ask Rep. Spartz why she supports the NIH cuts to IU… her district is chock full of IU employees who will be negatively affected! I desperately wish I could attend but will be in Portland for a meeting 😫

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Jamie Daw@jamiedaw.bsky.social · last yr.

🚨I converted the list of terminated #NIH grants (as of 3/22) into a google sheet. I added activity codes and award jurisdictions (see tabs for grant count and $ by each). Note this HHS list likely does not include all planned/completed terminations as of this date.🚨 Please use, share and distribute!

List of Terminated NIH Grants as of 3-22-2025 (Source: https://taggs.hhs.gov/Content/Data/HHS_Grants_Terminated.pdf)

docs.google.com

Jamie Daw@jamiedaw.bsky.social · last yr.

The list of terminated NIH grants is growing. Now 14 pages (was 6 pages last week).