Glad to see this work finally out! A joy working with the incredible Nurun Fancy to figure out the interaction between TREM2 and CD33, how TREM2 variants differ and what happens to other cell types in cases with TREM2 variants. Thanks to everyone involved in the study, it was a great team effort!

UK Dementia Research Institute@ukdri.ac.uk · 2w ago

Could a protective gene counteract risk of Alzheimer's in people with a high-risk gene variant? 🧬 Researchers led by Dr @jojacksonhere.bsky.social revealed how TREM2 – a well-known Alzheimer’s risk gene – interacts with CD33, a gene that can reduce disease risk. ukdri.ac.uk/news-and-eve...

#BcnPit let's do this. Looking forward to speaking tomorrow!

Could improving the way we collect & store brain tissue help better preserve it for research? A study by Dr @jojacksonhere.bsky.social & Prof Paul Matthews (UK DRI at Imperial) with researchers at McGill University reveals temperature plays a greater role than previously thought👉 lnkd.in/eG6yqJzD

sure grants and papers are exciting but seeing a new synaptic marker fluorescing down a microscope...priceless

Pleasure to collaborate with Jo Anne Stratton @theneuro.bsky.social funded by @hbhlmcgill.bsky.social and @ukdri.ac.uk. We show that post mortem processing conditions have differential effects on the brain's transcriptome. And temperature may play more of a role in good quality brain tissue.

Department of Brain Sciences@imperialbrains.bsky.social · 3mo ago

🧠 Temperature may matter more than time when it comes to preserving brain tissue after death – new research from @imperialmed.bsky.social could change how #brain banks work. 👉 www.imperial.ac.uk/news/article... @imperialcollegeldn.bsky.social @mcgill.ca @theneuro.bsky.social @ukdri.ac.uk

Super proud PI 🤩 Listen to Tatiana's findings about synaptic proteomic changes in AD progression!

Dementia Researcher@dementiaresearcher.bsky.social · 5mo ago

Poster in a Short 🎥 Tatiana Georgiades from @ukdri.ac.uk at Imperial College London shares her work at #ADPD2026 on synaptic proteome changes in Alzheimer’s. youtu.be/f30Rv_ZXXaU?...

the number of deadlines I have for the first 10 days of January is incredible...grant reviews, grant rebuttals, reference requests, marking...anyone would think that academics don't need a winter break...sigh

A great week at #AAIC25. Thanks to @alzheimerssoc.bsky.social and @alzassociation.bsky.social for the opportunity!

Was fun...and hot 🥵

Alzheimer's Association@alzassociation.bsky.social · last yr.

And they’re off! 🏃🏿‍♀️‍➡️🏃🏽‍♂️‍➡️🏃🏻‍♀️‍➡️ This morning, #AAIC25 attendees are enjoying stunning waterfront views as they make their way down Toronto’s scenic Martin Goodman Trail during our AAIC 5K Run/Walk.

Come and hear about how the synaptic protein, SV2a, is not always found at synapses. To find out where else it is, come and see our group's poster #384 today. #AAIC25

#AAIC25 Come and hear about synaptic proteomic changes over disease progression presented by the amazing Tatiana Georgiades in work funded by @alzheimerssoc.bsky.social

We have a new paper alert🎉 This work compiles all reported protein changes in the cerebrospinal fluid of Alzheimer’s patients across studies using mass spectrometry, Olink, and SomaScan platforms. Check it out here: academic.oup.com/braincomms/a... #Alzheimers

A compilation of reported alterations in the cerebrospinal fluid proteome in Alzheimer's disease

de Geus et al. report that a compilation of CSF proteomics studies in Alzheimer’s disease identified 61 consistently altered proteins across mass spectrome

academic.oup.com

Super proud of my PhD student, Tatiana, for being chosen as an @istaart.bsky.social Ambassador!

ISTAART@istaart.bsky.social · last yr.

Delighted to welcome our new class of ISTAART Ambassadors for 2025! This year's 43 Ambassadors represent 27 countries across the globe. They'll work with us at #AAIC25 Toronto & online & we'll be mentoring them over the next year! Meet them at alz.org/ISTAARTambassadors @alzassociation.bsky.social

really looking forward to speaking in this session!

British Pharmacological Society@britpharmsoc.bsky.social · last yr.

Join us at the @britishneuro.bsky.social Festival of Neuroscience 2025 (#BNA2025) where we'll deliver a joint workshop with @physoc.bsky.social on breakthroughs in treating #neurodegeneration! Register now: meetings.bna.org.uk/bna2025/bna2...

@imperialcollegeldn.bsky.social is looking for a new Head of Brain Sciences. Please repost and/or consider applying!! www.imperial.ac.uk/jobs/search-...

Description

Please note that job descriptions are not exhaustive, and you may be asked to take on additional duties that align with the key responsibilities ment...

imperial.ac.uk

Congratulations to my first Imperial PhD student Eleonore Schneegans! It's been a pleasure supervising you with Nurun Fancy and Paul Matthews. And thanks to the amazing examiners @sj-marzi.bsky.social and @ppetra.bsky.social. Pretty much an all woman dream team 😍

Dr Nurun Fancy at Imperial College London @imperialcollegeldn.bsky.social is seeking a PhD Student to explore the role of LRRK2 in cellular senescence in Parkinson's Disease. Closing date: 15th March #PhDPosition www.dementiaresearcher.nihr.ac.uk/job/phd-role...

PhD: Role of LRRK2 in cellular senescence in Parkinson’s Disease

Dr Nurun Fancy at Imperial College London is seeking a PhD Student to explore the role of LRRK2 in cellular senescence in Parkinson's Disease

dementiaresearcher.nihr.ac.uk

I don’t think many of my American scientist friends will leave the US despite the recent political changes affecting the NIH. But if they were interested, they should apply to become centre director here in Cardiff! www.ukdri.ac.uk/vacancies/ce...

Big week for the Jackson synaptics lab last week... 1st Imperial PhD thesis submitted, presented new data at Japan-UK neuroscience meeting and we have a new preprint out...a 🧵1/6

bioRxiv Neuroscience@biorxiv-neursci.bsky.social · 2y ago

A synaptic-astrocytic proteomic signature associated with synaptopathy in Alzheimer's Disease https://www.biorxiv.org/content/10.1101/2025.01.23.634408v1

Pleased to play a small part in this study. Congrats to everyone involved!

Alexander Haglund@haglunda.bsky.social · 2y ago

Very excited to share our latest publication in @NatureGenet! Our manuscript shows how Mendelian Randomization (MR) isolates putatively causal links between cell-type specific gene expression & brain phenotypes. www.nature.com/articles/s41... Tweetorial below 👇

Why do 95% of new drugs fail? Often, it's the wrong drug target. Researchers from @imperialbrains.bsky.social mapped how genes worked in 2.3M+ brain cells. The result? Dozens of promising new drug targets for brain conditions like #Alzheimers and #Parkinsons. www.imperial.ac.uk/news/259876/...

A great thread 🤩

Eddy Albarran@albarran.bsky.social · 2y ago

Here are *some* of my favorite studies on dendrites and spines from 2024 👀 - feeling very excited and inspired about the field! 🔥 Happy new year y'all!

Meet our amazing leader👩‍🔬 She will be sharing her journey of starting a new lab and much more. Stay tuned to know more about her experience! #Dementia

Dementia Researcher@dementiaresearcher.bsky.social · 2y ago

👩‍🔬 Meet Dr Becky Carlyle, from @ox.ac.uk our newest Dementia Researcher blogger. Her debut post "Opening Notes" sets the stage for a series on building research labs. Stay tuned! #ScienceBlogging #ResearchTips www.dementiaresearcher.nihr.ac.uk/blog-opening...

One official year in (after many official years) of the Jackson lab and celebrated with a 'sip n paint' neon masterclass. Looking forward to the year ahead and pleased to have the best team on board. Watch this space for our work coming out in the synaptic multi-'omics space in 2025

'women leave academia overall at higher rates than men at every career age, in large part because of strongly gendered attrition... ...women leave or consider leaving because of workplace climate more often than work-life balance' New study: www.science.org/doi/10.1126/... #womenInStem #PalAss24

Gender and retention patterns among U.S. faculty

Women faculty are more likely to leave their jobs than men, most often due to workplace climate, rather than work-life balance.

science.org

Nature Reviews Neuroscience Understanding the molecular diversity of synapses ＃Neuroscience www.nature.com/articles/s41...

Understanding the molecular diversity of synapses - Nature Reviews Neuroscience

The set of proteins present at synapses determines their heterogeneous functions and properties. In this Review, van Oostrum and Schuman describe the molecular mechanisms that contribute to the d...

nature.com

How to thank your lab mates: eight ways to show gratitude at the end of year - from Nature, feat. insights and pics from @prof-tregoning.bsky.social's lab! www.nature.com/articles/d41...

How to thank your lab mates: eight ways to show gratitude at the end of year

Alongside secret Santas and seasonal parties, many laboratories develop traditions to show appreciation to colleagues — from sweets and mulled wine to quizzes and ice-skating trips.

nature.com

One week left to apply for this job!! I'm looking for a research tech to come and work on Alzheimers and ApoE! If you love cell culture, astrocytes, APOE or just fun science with fun people then come do science with us in beautiful Dundee! tinyurl.com/a33kjn49 Seriously the sunsets are on point!

I've created a synapse starter pack, let me know if you want to be added go.bsky.app/GD1JwCq #neuroskyence

Hello World! New here, and a little bit scared of having to rebuild the Twitter network, but here we go: I'm a group leader at UK DRI and @kingsioppn.bsky.social. My lab works on #epigenetics in neurodegenerative diseases, to understand non-coding genetic and environmental risk factors 🧬🧠