Ross D. Jones, PhD
@jonesr18.bsky.social
HRBC Postdoctoral Fellow at UBC, Zandstra Lab; mammalian #synbio for production and programming of immune cell therapies https://scholar.google.com/citations?hl=en&user=hz1c6tsAAAAJ
🕙 9 days until the early-bird deadline for #Biocontrol26 Thrilled to highlight one of our speakers: Dr @noaholsman.bsky.social Noah brings together control, dynamical systems, and synbio to understand how feedback shapes robustness in biomolecular circuits. biocontrolseminars.org/biocontrol26
This Tuesday, June 30th at 8am PT / 11am ET / 5pm CET, join us for our online Biological Control Systems Seminar: Laurie Josselin from Liège University will present: "What we observe, what we control: microbial cell population dynamics in continuous bioreactors" More info: biocontrolseminars.org
Our next @bioctrl.bsky.social Seminar is Tuesday (May 26th) at 8am PT / 11am ET / 5pm CET! Kshitij Rai from UW and Ronan O'Connell from Baylor University will present Join us online: mit.zoom.us/j/9432532792...
The abstract submission deadline for Biocontrol26 is coming up Friday May 15th! @bioctrl.bsky.social 🦠🎮 If you are interested in giving a talk or presenting a poster in September at Oxford, you can submit an abstract and see more information on our website: biocontrolseminars.org/biocontrol26
Excited to have contributed to this comprehensive work led by Chris Johnstone in Katie Galloway's lab at @mit.edu! @sbmeubc.bsky.social @ubcmedicine.bsky.social @ubcpress.bsky.social @mitpress.bsky.social www.science.org/doi/10.1126/...
Gene syntax defines supercoiling-mediated transcriptional feedback
Gene syntax—the order and arrangement of genes and their regulatory elements—shapes the dynamic coordination of both natural and synthetic gene circuits. Transcription at one locus perturbs the transc...
science.org
Post 3/3 Direct application using STRAIGHT-IN Dual is also out at @science.org We show how gene syntax shapes gene expression through DNA supercoiling, revealing a new layer of regulation. We built homozygous hiPSC lines with identical payloads at CLYBL & AAVS1 Link: www.science.org/doi/10.1126/...
Join us online tomorrow Tuesday March 31 at 11am ET (5pm CET). Jake McGrath from UT Austin will present "Using control theory to study biology: a case study on muscle function and evolution" More information at biocontrolseminars.org
Like many labs, we have a Slack #papers channel for sharing and discussing cool work. For a while we talked about auto-linking to Zotero so we can collect all the papers into a shared repository. With help from @anthropic.com's Claude, I set this up in less than a day github.com/jonesr18/sla...
github.com
For the first time, we will host a Biocontrol Workshop in-person, September 14th-15th at Oxford! Abstract submission for talks and posters, and registration, are open. The abstract deadline is 15 May 2026, and the early-bird registration deadline is 15 June 2026.
Biocontrol Seminars@bioctrl.bsky.social · 5mo ago📣 Delighted to announce Biological Control Systems 2026, held in-person in Oxford (14-15 Sept) 📣 This event brings together a broad community across synbio, control, and AI/ML. We welcome contributions from theory to experiments. Abstracts + registration open: biocontrolseminars.org/biocontrol26
For the first time, researchers at UBC have demonstrated how to reliably produce #TCells from stem cells in a lab setting. See the work from Dr. @jonesr18.bsky.social, @kevinsalim.bsky.social, and the Zandstra & Levings labs: https://bit.ly/4qJcXhi Abstract: https://bit.ly/45QKIFo
Canadian breakthrough in stem cell engineering paves way for next-generation living drugs www.med.ubc.ca/news/stem-ce... @jonesr18.bsky.social @ubcmedicine.bsky.social More news → CanadaHealthwatch.ca 🍁
Finally out - fully-defined, feeder-free production of CD4+ helper T cells from induced pluripotent stem cells (iPSCs)! Turns out you need to turn Notch down.... a notch 🥁 And you need to fine-tune stimulation of the T cell receptor ⚖️ www.cell.com/cell-stem-ce...
Tunable differentiation of human CD4+ and CD8+ T cells from pluripotent stem cells
Jones et al. demonstrate that Notch signaling suppresses CD4+ (helper) T cell induction from PSCs and that manipulating TCR and Notch signaling enables control over CD4+ vs. CD8+ (cytotoxic) T cell pr...
cell.com
Check out our new paper entitled "Boolean Logic-based Controlled Release of Bioactive Proteins with Diversified Inputs", live in @angewandtechemie.bsky.social ! Growth factors, enzymes, nanobodies, and cytokines can now be "logically" delivered! 📜: onlinelibrary.wiley.com/doi/10.1002/...
📢 The full programme for the 2nd Workshop on Biological Control Systems (WBCS 2025) is out! 🗓️ 19 Nov 2025 | Online across time zones 🔗 Programme & info: biocontrolseminars.org/workshop-2025
Join us online tomorrow, Tuesday Oct 27 at 11am ET / 4pm CET. Tuan Pham from the University of Amsterdam will present his work on "Adaptation under Dynamic Genotype-Phenotype Map as Out-of-Equilibrium Learning". More information at biocontrolseminars.org
💻 Join us online, tomorrow Tuesday 30th September at 11am ET / 5pm CET for Eugenio Cinquemani's talk "Single-cell data reveal heterogeneity of investment in ribosomes across a bacterial population". As always more information on our website: biocontrolseminars.org
Now with a new host @michaelajonesphd.bsky.social! Looking forward to the next phase of EBRC events!
Arren J. Liu@arrenliu.bsky.social · 11mo agoThe next @ebrc.org panel hosted by the Student and Postdoc Association is Sept 25! Re-post/share! 🧬 Are you a grad student thinking about pursuing a postdoc? 📺 Attend our panel to learn more about postdoc life and how to make the most of it! 🔗 Register here: forms.gle/FQLTRcP8wR2h...
Now with a new host @michaelajonesphd.bsky.social! Looking forward to the next phase of EBRC events!
Arren J. Liu@arrenliu.bsky.social · 11mo agoThe next @ebrc.org panel hosted by the Student and Postdoc Association is Sept 25! Re-post/share! 🧬 Are you a grad student thinking about pursuing a postdoc? 📺 Attend our panel to learn more about postdoc life and how to make the most of it! 🔗 Register here: forms.gle/FQLTRcP8wR2h...
Had a fun chat with @jennbrophy.bsky.social! Listen in to hear about the solarpunk future of plant bioengineering ☀️🌿
📢Join us for our online seminar tomorrow Tuesday Aug 26 at 11am ET (5pm CET) Frank Britto Bisso from Carnegie Mellon University will present "Programming genetic circuits that operate as neural networks" As always more information on our website biocontrolseminars.org
Join us tomorrow Jul 29 at 11am ET for our monthly online seminar on biological control. Daniel Eaton from Harvard Medical School will present "Essentialome-Wide Multigenerational Imaging Reveals Mechanistic Origins of Cell Growth Laws" More info: biocontrolseminars.org
In 1965, Margaret Dayhoff published the Atlas of Protein Sequence and Structure, which collated the 65 proteins whose amino acid sequences were then known. Inspired by that Atlas, today we are releasing the Dayhoff Atlas of protein sequence data and protein language models.
📢 The second edition of our Workshop on Biological Control Systems is happening online on 19 Nov 2025, with sessions across Asia, Europe, and the Americas. 📢 Talks & posters abstract submissions: Aug 1 & Aug 15 Keynotes and more info on our website: www.biocontrolseminars.org/workshop-2025
Biocontrol Seminars - Workshop 2025
The Second Edition of our Workshop on Biological Control Systems will be held on November 19, 2025
biocontrolseminars.org
Join us online today Tue 27 May, as Maren Phillips from the University of Bonn presents "Hybrid neural and mechanistic ODEs for systems biology" at 5:00 pm CEST / 11 am EDT / 8 am PDT! As always more information at biocontrolseminars.org
New on our Slack radar: Manoj & Vecchio, Resource competition shapes CRISPR-mediated gene activation bioRxiv (26 Apr 2025)
I'd like to share a little bit of happy lab news in these chaotic times: a new preprint, driven by the brilliant Qinhao Cao! www.biorxiv.org/content/10.1... We address a big challenge in synbio: If you give me a protein "X", how can I give you a version of X whose activity is controlled by a kinase?
Fundamental Trade-Offs in the Robustness of Biological Systems with Feedback Regulation pubs.acs.org/doi/10.1021/...
Fundamental Trade-Offs in the Robustness of Biological Systems with Feedback Regulation
Natural biological systems use feedback regulation to effectively respond and adapt to their changing environment. Even though in engineered systems we understand how accurate feedback can be dependin...
pubs.acs.org
