Preclinical evaluation of nitrated α-synuclein-specific CAR-Treg therapy in Parkinson’s disease @cp-cellrepmed.bsky.social www.cell.com/cell-reports...
Kevin Salim
@kevinsalim.bsky.social
Graduate Student | Levings Lab | BC Children’s Hospital Research Institute | Regulatory T Cells | He/him 🏳️🌈
Thanks @labwaggoner.bsky.social! All datasets publicly available on GEO. While we focus on #ILC2, #ILC3s and #NKcells, we capture all immune cells in human spleen. So hoping the datasets can be a good resources for the community!
Congrats, @sarahcolpitts.bsky.social & @sarahcrome.bsky.social! Spatial and functional specialization of human splenic innate lymphoid cells (#ILC #NK) www.nature.com/articles/s41...
Review @moltherapy.bsky.social @mklevings.bsky.social Engineering human T cells with antigen receptors for immune regulation in autoimmune disease and transplantation www.cell.com/molecular-th...
Engineering human T cells with antigen receptors for immune regulation in autoimmune disease and transplantation
Engineered T cell therapies have transformed cancer treatment and similar principles are being applied in autoimmunity and transplantation. In this review Levings and colleagues discuss strategies to ...
cell.com
Reproducible detection of antigen-specific T cells and Tregs via standardized and automated activation-induced marker assay workflows
Reproducible detection of antigen-specific T cells and Tregs via standardized and automated activation-induced marker assay workflows
Halvorson et al. characterize the variability associated with AIM assays and present strategies to minimize technical variability. Box-Cox-based correction for background signals, optimized AIM protocols for CD4+ and CD8+ T cells and Tregs, and automated gating software reduce unwanted variability and enhance signal detection, streamlining AIM assays for clinical adoption.
dlvr.it
Treatment with an IL-2–TGFβ ‘surrogate’ co-agonist quelled immune activation in mouse models of allergen-induced allergic inflammation and self-antigen-driven autoimmune neuroinflammation @stanforduniversity.bsky.social @nature.com www.nature.com/articles/s41...
Luo Ting Huang, Yaser Tahamtani, @nictitate.bsky.social & co explored the possibility of magnetic selection of insulin-expressing stem cell‑derived β‑cells using a CRISPR/Cas9 technology and transmembrane glycoprotein CD19 as a marker. @bcchresearch.bsky.social Read: doi.org/10.1242/dmm....
This is an OUTSTANDING LIFE-CHANGING outcome, based on research and healthcare by @turveylab.bsky.social and colleagues @bcchresearch.bsky.social Hooray for the family! Hooray for Stuart T & the other clinicians and scientists! ❤️🎉❤️🎉❤️🎉❤️
Ian Weissman, DO@drianweissman.bsky.social · 6mo agoMan cured of rare disease in world-first for a new gene-editing technology. www.ctvnews.ca/vancouver/ar...
Researchers in B.C. have unlocked a way to grow vital immune cells from stem cells. This breakthrough could lead to mass produced cancer therapies that are faster and cheaper than current custom treatments.
Review @natbiotech.nature.com Clinical progress of engineered cellular immunotherapies for autoimmunity www.nature.com/articles/s41...
Review @annualreviews.bsky.social Tissue Regulatory T Cells www.annualreviews.org/content/jour... @labliston.bsky.social
Very happy to share the final chapter of my postdoc work with Boris Reizis @NYU @uchicagocoi.bsky.social published today in @science.org! We identify and define the role of transcription factor ETV3 in the tolerogenic function of dendritic cells (DCs). 1/ www.science.org/doi/10.1126/...
Transcription factor Etv3 controls the tolerogenic function of dendritic cells
Dendritic cells (DCs) facilitate the maintenance of immunological tolerance in the steady state. We report that transcription factor Etv3 is preferentially expressed in mature DCs, including tissue-de...
science.org
Overjoyed to share our new work exploring the antigen specificity of CSF-expanded CD8+ T cells in #multiplesclerosis #EBV in @natimmunol.nature.com #immunology 🧪🧵1/ www.nature.com/articles/s41...
Antigen specificity of clonally enriched CD8+ T cells in multiple sclerosis - Nature Immunology
Sabatino and colleagues examine expanded CD8+ T cell clonotypes from a small cohort of multiple sclerosis patients. They identified several cognate peptide epitopes that derive from Epstein–Barr virus...
nature.com
Please share and distribute ILC6 6th International Conference on Innate Lymphoid Cells in Vancouver, BC Canada Abstract submission and registration are open: ilc6vancouver.com #immunosky #ILC6vancouver #ILC6 Lots of presenter spots available!!! Get those hot abstracts out.
The new Crome Lab at BC Cancer is up and running — and we’re hiring! We’re recruiting a PDF for a newly funded project on ILCs & NK cells in Type 1 Diabetes, using spatial genomics and single-cell approaches. 🔗 jobs.phsa.ca/job/postdoct... #Immunology #SingleCell #SpatialGenomics #Type1Diabetes
Postdoctoral Fellow - Innate Lymphoid Cells and Spatial Genomics in Type 1 Diabetes, Crome Lab, Terry Fox Laboratory - BC Cancer Vancouver | Working at Provincial Health Services Authority | Careers a...
Postdoctoral Fellow - Innate Lymphoid Cells and Spatial Genomics in Type 1 Diabetes, Crome Lab, Terry Fox Laboratory BC Cancer Vancouver, BC We are recruiting a highly motivated Postdoctoral Fellow to...
jobs.phsa.ca
New publication @diabetologiajnl.bsky.social led by a fantastic former fellow on our team @hdenroche.bsky.social. Islet amyloid, long viewed as pathogenic for beta cells, surprisingly disrupts antigen presentation and delays autoimmune diabetes in NOD mice.
Diabetologia@diabetologiajnl.bsky.social · 8mo agoWhile islet amyloid harms β cells in T2D, research reveals amyloid protects against β cell autoimmunity and diabetes in NOD mice by disrupting MHCII antigen presentation in islet macrophages link.springer.com/article/10.1... 🔓
Check out our protocol for streamlined isolation and immunophenotyping of leukocytes from various mouse tissues! Excited to implement these in our in vivo mouse models to better understand the immune system and harness it for safe and effective immunotherapies. @um-radyfhs.bsky.social
STAR Protocols@cp-starprotocols.bsky.social · 8mo agoProtocol for multi-organ isolation of murine leukocytes for flow cytometry #protocol #starprotocols #cellpress
For the first time, researchers at UBC have demonstrated how to reliably produce #TCells from stem cells in a lab setting. See the work from Dr. @jonesr18.bsky.social, @kevinsalim.bsky.social, and the Zandstra & Levings labs: https://bit.ly/4qJcXhi Abstract: https://bit.ly/45QKIFo
Excited to share this work done in collaboration between @mklevings.bsky.social lab and @jonesr18.bsky.social from Peter Zandstra’s lab, on making human CD4 T cells from pluripotent stem cells!
Ross D. Jones, PhD@jonesr18.bsky.social · 8mo agoFinally out - fully-defined, feeder-free production of CD4+ helper T cells from induced pluripotent stem cells (iPSCs)! Turns out you need to turn Notch down.... a notch 🥁 And you need to fine-tune stimulation of the T cell receptor ⚖️ www.cell.com/cell-stem-ce...
Finally out - fully-defined, feeder-free production of CD4+ helper T cells from induced pluripotent stem cells (iPSCs)! Turns out you need to turn Notch down.... a notch 🥁 And you need to fine-tune stimulation of the T cell receptor ⚖️ www.cell.com/cell-stem-ce...
Tunable differentiation of human CD4+ and CD8+ T cells from pluripotent stem cells
Jones et al. demonstrate that Notch signaling suppresses CD4+ (helper) T cell induction from PSCs and that manipulating TCR and Notch signaling enables control over CD4+ vs. CD8+ (cytotoxic) T cell pr...
cell.com
Big breakthrough for living drugs. UBC researchers have discovered how to grow “helper” immune cells from stem cells—paving the way for more effective and accessible off-the-shelf immune therapies. Learn more: news.ubc.ca/2026/01/stem...
🚨 Introducing: The next FOCIS Journal Club 🎓 CAR Treg cells mediate linked suppression and infectious tolerance in islet transplantation in mice 🗓️ Wed, Jan 28, 2026 🕚 10 AM–11 AM CT 🎤 Christine Wardell, PhD Student & Megan Levings, PhD 🔗: zurl.co/gsIJC
🚀 Our new Publication in Nature Biomedical Engineering!🎉 📄 Title: Generation of T cells with reduced off-target cross-reactivities by engineering co-signalling receptors 🔗 Read the full paper here: www.nature.com/articles/s41...
Generation of T cells with reduced off-target cross-reactivities by engineering co-signalling receptors - Nature Biomedical Engineering
This study shows that T cell cross-reactivity is influenced by the co-signalling molecules CD5, CD8 and CD4, and that cytotoxic T cells with a CD8→CD4 co-receptor switch show reduced cross-reactivity ...
nature.com
While islet amyloid harms β cells in T2D, research reveals amyloid protects against β cell autoimmunity and diabetes in NOD mice by disrupting MHCII antigen presentation in islet macrophages link.springer.com/article/10.1... 🔓
Islet amyloid disrupts MHC class II antigen presentation and delays autoimmune diabetes in NOD mice - Diabetologia
Aims/hypothesis Islet amyloid contributes to beta cell failure in type 2 diabetes through several mechanisms, one being the potent induction of local islet inflammation through activating inflammatory...
link.springer.com
@biorxivpreprint.bsky.social Clinical development of gene edited tacrolimus-resistant Treg (FKBP12KO-Treg) to enable simultaneous immunosuppression and support of immune regulation www.biorxiv.org/content/10.6...
Clinical development of gene edited tacrolimus-resistant Treg (FKBP12KO-Treg) to enable simultaneous immunosuppression and support of immune regulation https://www.biorxiv.org/content/10.64898/2025.12.10.693159v1
Erythropoietin receptor on cDC1s dictates immune tolerance @nature.com @stanforduniversity.bsky.social www.nature.com/articles/s41...
Type 1 diabetes is associated with impaired T cell effector differentiation and regulatory T cell dysfunction, both of which may contribute to immune imbalance and loss of self-tolerance @natcomms.nature.com @adaptiveimmunity.bsky.social @czechacademy.bsky.social www.nature.com/articles/s41...
Engineered β cells with a mutant CD155 help evade immune attack, offering a promising therapeutic approach for type 1 diabetes @bruskolab.bsky.social www.science.org/doi/10.1126/...
Human stem cell-derived β cells expressing an optimized CD155 reduce cytotoxic immune cell function for application in type 1 diabetes
Engineered β cells with a mutant CD155 help evade immune attack, offering a promising therapeutic approach for type 1 diabetes.
science.org