Josh Currie

@joshcurrie.bsky.social

Studying principles of tissue regeneration in the axolotl and looking toward regenerative therapies. Asst. Professor at Wake Forest University. Views my own. He/him. https://www.currie-regenerationlab.com/

Flatworms have incredible regenerative capacity due to having many stem cells throughout the body. @zayaslab.bsky.social shows the role of soxB1-2, which promotes DNA unpacking, and Ephrin signalling in mechanosensory neuron differentiation. #2026SDB Papers: elifesciences.org/reviewed-pre... and ⤵️

SoxB1-mediated chromatin remodeling promotes sensory neuron differentiation in planarians

Abstract. Understanding how adult stem cells generate neurons is critical for advancing regenerative medicine. However, few in vivo models enable studying

academic.oup.com

In the last 48 hours of grant prep and I can ALMOST see the light at the end of the tunnel 🥴 But having a breakthrough in your experimental design while writing is always the thing that makes it just a little less terrible 😄

🐙 Octopuses appear to have evolved a ribosomal innovation that increases protein translation fidelity. *suggests that evolution can tune core components of the proteostasis machinery, extending adaptation beyond gene regulation www.biorxiv.org/content/10.6...

Evolution of a core ribosomal innovation in octopus

Much of biology focuses on how genetic changes mediate new functions, but less attention is given to adaptations in other steps of the central dogma. Octopuses exhibit complex nervous systems and soph...

biorxiv.org

‘Odyssey’ comes from the name Odysseus. The first known use of ‘odyssey’ as a generic term for “journey” was in Robert Louis Stevenson’s “Kidnapped” in 1886.

We had a great time yesterday talking to 3rd-7th graders at the Kaleideum's summer STEM camp. We talked about the weird, wild, and wonderful axolotl with a guest appearance from their adopted axolotl "Pinky"

Summer research students showing lab samples to STEM summer campers

I really love being a scientist and doing benchwork. To me, it's an artisan craft - working with your hands, techniques honed with years of practice and intuition, training apprentices, creating new and interesting things. I hope that that type of science will endure

“The opposition is overwhelmingly grassroots rather than orchestrated. Form letters make up only about 16 percent of all comments (roughly 8,400 comments across 210 distinct campaigns), and only about one in eight opposing comments came from a form-letter campaign...

Tech Policy Press@techpolicypress.bsky.social · 3w ago

Using an open-source pipeline to read every comment on OMB's proposed grants rule that could have significant impact on science and technology research funding, Christopher Steven Marcum and Abigail Haddad find the verdict "clear and lopsided": ~94% oppose it.