Excellent response from Dr. Bertagnolli to the article from Scott Atlas www.linkedin.com/pulse/dont-a...

Don't abolish the NIH. Fix it.

Scott Atlas wants to abolish the National Institutes of Health and let markets take over ("NIH is a government weapon for political power. Abolish it," Washington Post, July 2).

linkedin.com

Excited to share our preprint introducing ASHI: the Atlas of SLiM-mediated Human protein-protein Interactions. By screening 800+ domains against the human intrinsically disordered regions, we map 20,000 SLiM-mediated interactions. Many thanks to everyone involved! www.biorxiv.org/content/10.6...

An Atlas of Short Linear Motif-Mediated Human Protein-Protein Interactions

Short linear motifs (SLiMs) within intrinsically disordered protein regions mediate transient interactions crucial for cell physiology. However, the global interaction landscape of human SLiMs remains...

biorxiv.org

A giant in the early mechanisms and regulation of transcription

Alexis Verger 🧬🧫🧪@alexis-verger.cpesr.fr · 3mo ago

#RIP Pierre Chambon (1931-2026) 1963 PARP 1970 RNA Pol II 1975 Nucleosome 1977 Split genes 1980 Promoter 1983 enhancer 1986 Nuclear receptor

Gratified and humbled to receive the Gold Medal, Society of Breast Imaging, for a life's work/career that is its own reward. Thank you to the many grant-funding agencies, co-investigators, and participants in research. We have more to do! @bcrfcure.bsky.social densebreast-info.org/remarks-from...

Remarks from Dr. Wendie Berg, 2026 SBI Gold Medalist | DenseBreast-info, Inc.

We are so proud of our Chief Scientific Advisor, Dr. Wendie Berg, who was awarded the SBI Gold Medal at this year’s Society of Breast Imaging Annual Meeting — the organization’s highest honor. We are ...

densebreast-info.org

new publication in #Nature Commun evaluating PPI prediction by #AlphaFold & co for yeast and human compared to exp. screening. We show AF predictions at stringent cut-off are high quality. But true novelty is sparse and the experiment outperforms pred. nearly 40-fold. www.nature.com/articles/s41...

This has to be the best advertising link ever.

WELL NOW, would you look at that? A massive, 4-YEAR-LONG study of NEARLY 30 MILLION people in France found that individuals who received a COVID-19 mRNA vaccine had a 74% LOWER risk of death from severe COVID-19 compared to unvaccinated individuals and ZERO increased risk of all-cause mortality.

I hadn't seen this before. This is pretty remarkable. Earth and Moon in one NASA photo. ht @astrokatie.com

Our latest paper is out! We built a large-scale mutational map of amylin to understand how sequence drives #amyloid formation, a process linked to type 2 #diabetes🩸📈📉. It’s a step towards connecting molecular mechanisms with human genetic variation in a systematic way.

IBEC | Institute for Bioengineering of Catalonia@ibecbarcelona.eu · 4mo ago

🔬 Investigadores de l'#IBEC creen un mapa mutacional de l’amilina que mostra com certes mutacions poden accelerar o frenar la formació d’agregats tòxics vinculats a la diabetis tipus 2.  📖 https://ibecbarcelona.eu/an-unprecedented-mutation-map-reveals-how-amylin-mutations-influence-type-2-diabetes/

Validation of aggressive LDL lowering to reduce major adverse cardiovascular events, a randomized trial targeting LDL < 55 mg/dl. In participants with atherosclerotic cardiovascular disease (secondary prevention) [we didn't have the data from a randomized trial before] www.nejm.org/doi/full/10....

NIH restrictions on foreign research partnerships significantly impacted 1 in 4 U.S. scientists www.statnews.com/2026/03/27/n... via @statnews.com #HHS #NIH #science #publichealth

NIH restrictions on foreign research partnerships significantly impacted 1 in 4 U.S. scientists

In a survey of NIH-funded scientists, 25% said their research had been impacted a great deal or a fair amount by a move away from foreign subawards.

statnews.com

OMB has posted the full-year apportionments for NIH. openomb.org/file/11511545 I believe this means that NIH now has the spending authority to fund grants! There may be nuances and I will be tracking these as best I can.

National Library of Medicine and 24 other accounts | 11511545

Apportionment file 11511545 (National Library of Medicine and 24 other accounts) retrieved from OMB public records

openomb.org

Action Item...Action Item...Action Item Time to comment on the Framework for the NIH-Wide Strategic Plan grants.nih.gov/grants/guide... Comments due by May 16, 2026

"I Wrote Research Funding Announcements for NIH for 22 Years. This Year They’ve Published 14. How NIH went from 756 funding announcements to 14 in two years — and what it means for every disease that depends on federal research" elizabethginexi.substack.com/p/i-wrote-re...

The Gur lab has published a new article in JACS Au, a journal of the American Chemical Society, that sheds light on how a promising class of cancer-fighting molecules works at the atomic level. Read more about the research on protein phosphate 2A, an "off-switch" for cancer: tinyurl.com/JACSPP2A

All projects The fiscal year 2026 appears to be flattening out a bit in the past week. 2/9

We are deeply saddened to share the news of the passing of David Botstein, a towering figure in modern #genetics and a foundational force behind SGD. www.yeastgenome.org/blog/in-memo... #yeast #modelOrganism

New paper alert: Paralog interference contributes to the preservation of genetic redundancy www.cell.com/current-biol...

Paralog interference contributes to the preservation of genetic redundancy

Duplicated self-interacting proteins can interact and interfere with each other’s function. Cisneros, Mattenberger, et al. show that selection against interfering loss-of-function alleles extends the ...

cell.com

Final version @nature.com of our paper describing unconventional multicellular development in a choanoflagellate inhabiting an extreme environment. A ton of new data since the first @biorxivpreprint.bsky.social preprint (which we've kept updating). A brief 🧵 (carried over from the old place)

Nature Portfolio@natureportfolio.nature.com · 5mo ago

A study in Nature shows that the single-celled form of a tiny, aquatic organism can turn into a multicellular version by three different routes. The discovery adds insight to the possible origins of multicellular life, suggesting a previously unrecognized degree of flexibility. 🧪

Seattle locals: thesis defense Tuesday at 11:30 in Foege! Mapping the functional landscape of the pharmacogene CYP2D6 in Saccharomyces cerevisiae by Gabby Ferra, joint student between my lab and @kelleyharris.bsky.social

In #GENETICS, a new model developed by @christianlandry.bsky.social and colleagues examines how molecular dominance determines total protein activity and contributes to phenotypic dominance. buff.ly/CfaTDp7

More on NSF funding data A deeper dive into the numbers of awards by Directorate. 1/9

a picture of a person in the water with the words call of the deep below it

ALT: a picture of a person in the water with the words call of the deep below it

media.tenor.com

Check out our new work now published in G3! We use proteomics and phosphoproteomics to study how cells cope with tRNA variants that mis-insert amino acids.

Genetics Society of America@genetics-gsa.bsky.social · 6mo ago

Using proteomics approaches, @matthewberg22.bsky.social et al. show how mistranslating tRNAs in #yeast alter the abundance and phosphorylation of proteins involved in proteostasis, cell cycle, and translation. Learn more in #G3journal: buff.ly/7KW7m0K

We’re happy to share our 2025 Annual Report! A year of "momentum and connections"! ➡️ zenodo.org/records/1833... #AnnualReport #GlobalAlliance #FunctionalGenomics #VariantEffect #Community

We’re excited to share our latest preprint on the mechanism of excised linear intron stabilization in yeast! This work was led by PhD student @glennli.bsky.social and was a wonderful collaboration with @maxewilkinson.bsky.social. Link: www.biorxiv.org/content/10.6... (1/4)

Thanks for everything, Dr. Foege. May we all work to be more diligent stewards of the legacy you left us: to work every day to care for all of our neighbors, present and future, a bit better than we did yesterday.

Kathleen Bachynski@bachynski.bsky.social · 6mo ago

A public health giant has passed. “Among public health professionals, Dr. Foege was almost without peer… In 2012, President Barack Obama awarded him the Presidential Medal of Freedom, the nation’s highest honor given to a civilian.”

Pitt researchers are raising the bar for microprotein discovery. By reassessing detection methods, Aaron Wacholder and Anne-Ruxandra Carvunis reveal why standardized protocols are essential for uncovering these elusive proteins' roles in health and disease. tinyurl.com/NatureWachol...

Community benchmarking and evaluation of human unannotated microprotein detection by mass spectrometry based proteomics - PubMed

Thousands of short open reading frames (sORFs) are translated outside of annotated coding sequences. Recent studies have pioneered searching for sORF-encoded microproteins in mass spectrometry (MS)-based proteomics and peptidomics datasets. Here, we assessed literature-reported MS-based identificati …

tinyurl.com

Gratitutde to all NIH study section participants who are participating in rescheduled meetings now and in January. Thank you for your service and thanks also to the hard working NIH staff who are making these happen. 🥰🧪

Here are the curves for the number of non-competitive renewal (Type 5) awards. The curve for fiscal 2026 lags behind earlier years. This lag is likely due to the extended government shutdown. 2/6

We are thrilled to share our latest work uncovering the mechanistic basis of target-directed microRNA degradation (TDMD). This work was driven by @jakobfarnung.bsky.social and @elenaslo.bsky.social in a fantastic collaboration with Brenda Schulman's lab. tinyurl.com/E3TDMD (1/5)