This is great to see! So important to recognise and celebrate the fantastic work going on in this area 👏
Julie Fabre
@juliefabre.bsky.social
Postdoc in Ilana Witten's lab & Schmidt Science Fellow 2025. Former PhD in Kenneth Harris and Matteo Carandini's lab. Follow for updates on bombcell & other Neuropixels software.
We're launching the PNI Open Science Awards at @princetonneuro.bsky.social, a pilot program to recognize the tools, datasets, and protocols that advance open, reproducible neuroscience with @maxime-beau.bsky.social. This work is foundational to modern neuroscience but rarely gets formal credit.
Data-driven model discovery 🔁 Model-driven experiment selection. For mechanistically-interpretable models! From Google DeepMind Neuroscience Lab, let by @noemielteto.bsky.social
Noémi Éltető@noemielteto.bsky.social · 2mo agoFirst paper since joining Google DeepMind! We present 🌍ATLAS (Active Theory Learning for Automated Science), a pipeline that generates interpretable mechanistic models from data and optimizes experiments to test them. Thread below
Losing one side of Superior Colliculus is bad, but losing both sides seems fine. Wait, what? Flora & team discovered why: both sides press for contra actions and against inaction, obeying an incredibly simple additive rule. Out today in bioRxiv: www.biorxiv.org/cgi/content/...
New method for identifying the fine transcriptomic types of thousands of neurons recorded in vivo!
Excited to share a new review by @kocherlab.bsky.social and me: Nature-inspired neuroscience We discuss diverse sensory systems and behaviors across the animal kingdom and argue for their integration into neuroscience. New tools in diverse systems are making this possible ✨ tinyurl.com/y5y9du27
How does blood flow relate to brain activity? We discovered that it reflects two neural populations affected oppositely by arousal. Together, they explain neurovascular coupling in all brain regions and brain states! Out today in Nature: rdcu.be/fdC2A @uclbrainscience.bsky.social
New preprint, on a very different topic: a mathematical theory of evolution for self-designing AI. AI is increasingly designed by AI. What systems might emerge after generations of self-designing AIs competing for computing resources? ↓ arxiv.org/abs/2604.05142
A mathematical theory of evolution for self-designing AIs
As artificial intelligence systems (AIs) become increasingly produced by recursive self-improvement, a form of evolution may emerge, with the traits of AI systems shaped by the success of earlier AIs ...
arxiv.org
Want to explore connectivity & projection patterns yourself, like we do here? We released brain_street_view to let you pick any injection site in the Allen Connectivity Atlas and visualize where it projects in your favorite region of interest: github.com/Julie-Fabre/brain_street_view
Julie Fabre@juliefabre.bsky.social · 4mo agoHow do the basal ganglia turn what you see into what you do? New preprint w/ @kenneth-harris.bsky.social, @flickerfusion.bsky.social & @carandinilab.net: we recorded across striatum, GPe & SNr in a Go/NoGo task. Striatum encodes which stimulus, GPe & SNr encode action. 🧵 biorxiv.org/content/10.6...
How do the basal ganglia turn what you see into what you do? New preprint w/ @kenneth-harris.bsky.social, @flickerfusion.bsky.social & @carandinilab.net: we recorded across striatum, GPe & SNr in a Go/NoGo task. Striatum encodes which stimulus, GPe & SNr encode action. 🧵 biorxiv.org/content/10.6...
Sequences are everywhere! In every brain region. And are written in stone. Invariant Activity Sequences Across the Mouse Brain. Out today, by Célian Bimbard, with @kenneth-harris.bsky.social. Based on data by Célian and by @intlbrainlab.bsky.social. www.biorxiv.org/content/10.6...
Thanks, Adrian! I’m excited to be starting a lab at the University of Utah (theluolab.org)! We’re recruiting at all levels. If you’re excited about neural computation, large-scale multi-region recordings, and machine learning, let’s talk! And yes, the mountains are as incredible as they say!
Luo Lab
theluolab.org
All talks of the 2025 UCL #Neuropixels course are now available: www.youtube.com/playlist?lis... For more information on the course see the website: www.ucl.ac.uk/neuropixels/... And for those at #SfN, come say hi at the #Neuropixels booth (Number 3731) or at my Poster 👋. Happy Neuropixeling!
2025 UCL Neuropixels Course - YouTube
Lectures at the 2025 UCL Neuropixels course (https://www.ucl.ac.uk/neuropixels/training/2025-neuropixels-course)
youtube.com
Our lab is looking for a postdoc! We have interesting projects and cutting-edge techniques such as Neuropixels Opto, Light Beads Microscopy and more. We would be delighted to receive your application. Deadline is 25 November 2025. More info here: www.ucl.ac.uk/cortexlab/po...
Happy to share our primer on Basal Ganglia - Brainstem interactions! From how the basal ganglia communicate with Brainstem motor circuits to how these activity patterns might come about! With Silvia Arber, now out in Current Biology www.cell.com/current-biol...
Basal ganglia–brainstem interactions
Our body executes many different movements with precision. Falasconi and Arber describe how basal ganglia interact with brainstem circuits controlling body movements and propose a movement-specific li...
cell.com
Neuropixels Ultra! By @steinmetzneuro.bsky.social, who led a big collaboration www.sciencedirect.com/science/arti...
Ultra-high-density Neuropixels probes improve detection and identification in neuronal recordings
To understand the neural basis of behavior, it is essential to sensitively and accurately measure neural activity at single-neuron and single-spike re…
sciencedirect.com
How does the brain decide? 🧠 Our new @nature.com paper shows that neural activity switches from an 'evidence gathering' to a 'commitment' state at a precise moment we call nTc. After nTc, new evidence is ignored, revealing a neural marker for the instant when the mind is made up. rdcu.be/eGUrv
Transitions in dynamical regime and neural mode during perceptual decisions - Nature
Simultaneous recordings were made of hundreds of neurons in the rat frontal cortex and striatum, showing that decision commitment involves a rapid, coordinated transition in dynamical regime and neura...
nature.com
PSA: don't buy duragel from Cambridge Neurotech, it's a scam! 🚨 They charge $200 (incl. shipping) for a 16 ml spout. But duragel is just DOWSIL 3-4680 (see paper below) of which you can buy a large container of 210 ml for only $110. That's 24 times cheaper! 💸 www.sciencedirect.com/science/arti...
Artificial dural sealant that allows multiple penetrations of implantable brain probes
This study reports extensive characterization of the silicone gel (3-4680, Dow Corning, Midland, MI), for potential use as an artificial dural sealant…
sciencedirect.com
We're looking for a research assistant to work in our neuroscience lab at @princetonneuro.bsky.social @hhmi.org where we study learning and decision-making circuitry. Apply here: research-princeton.icims.com/jobs/21001/r... Pls share w/ anyone who might be interested!
New by Agnès Landemard (@agnesland.bsky.social) & co Brainwide blood volume reflects opposing neural populations Brainwide fluctuations in blood volume arise from two populations with opposite relation to brain state and distinct relationships to blood supply www.biorxiv.org/content/10.1...
The firing of neural populations is high-dim even if their subthreshold activity is low-dim! This work by @bio-emergent.bsky.social and @haydari.bsky.social shows how, with a solvable model, a data analysis technique, and data from mouse visual cortex: www.biorxiv.org/content/10.1...
High-dimensional neuronal activity from low-dimensional latent dynamics: a solvable model
Computation in recurrent networks of neurons has been hypothesized to occur at the level of low-dimensional latent dynamics, both in artificial systems and in the brain. This hypothesis seems at odds ...
biorxiv.org
🚀 We are excited to share that bombcell is now available in Python! 🐍 Automatically sort your units into good/MUA/noise/non-somatic using quality metrics and interpretable & adjustable classification thresholds. pip install and play around with our toy dataset: 🔗 github.com/Julie-Fabre/...
GitHub - Julie-Fabre/bombcell: Automated quality control, curation and neuron classification of spike-sorted electrophysiology data
Automated quality control, curation and neuron classification of spike-sorted electrophysiology data - Julie-Fabre/bombcell
github.com
Our work, out at Cell, shows that the brain’s dopamine signals teach each individual a unique learning trajectory. Collaborative experiment-theory effort, led by Sam Liebana in the lab. The first experiment my lab started just shy of 6y ago & v excited to see it out: www.cell.com/cell/fulltex...
Forelimb movement control at the basal ganglia - brainstem interface! Happy to finally share this work from me and @harsh-kanodia.bsky.social with Silvia Arber! @biozentrum.unibas.ch @fmiscience.bsky.social www.nature.com/articles/s41...
Dynamic basal ganglia output signals license and suppress forelimb movements - Nature
Basal ganglia output neurons fire dynamically in bidirectional and movement-specific patterns to license forelimb movements.
nature.com
🔊New resource: Bombcell, automated quality control for extracellular electrophysiology 💡This is an #opensource, user-friendly toolbox that streamlines quality control for spike sorting outputs. 👩🔬Develop by Julie M. J. Fabre 🔗Link: open-neuroscience.com/en/post/bomb... #OpenScience #Neuroscience
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Many of us use 2p scopes to image 3D volumes of brain. But then we analyze the data plane by plane, resulting in duplicated neurons, missed neurons, and low s/n. Let's go 3D! Suite3D: Volumetric cell detection for two-photon microscopy by @haydari.bsky.social & team. www.biorxiv.org/content/10.1...
🎓 Qu’est-ce que le programme Médecine-Sciences ? Après dix ans d'existence, quel bilan ? Son directeur, Alain Bessis, professeur attaché à l'ENS-PSL et directeur de recherche au CNRS revient sur la décennie écoulée et les enjeux pédagogiques du programme. À lire ici 👉 bit.ly/3Gm0RsA
Our paper describing UnitMatch software "tracking neurons across days with high-density probes", appeared in this month's issue of #NatureMethods. Missed it? Read it here: www.nature.com/articles/s41...
How do we associate the flavors we experience during a meal 🍽️😋 with postingestive effects like food poisoning 🤢🤮 that arise much later? Our answer in @nature.com this week: Illness signals from the gut reactivate and strengthen flavor representations in the amygdala. 📄: nature.com/articles/s41...
A neural mechanism for learning from delayed postingestive feedback - Nature
Illness signals from the gut reactivate and strengthen flavour representations in the amygdala to support learning from delayed postingestive feedback.
nature.com