Extension of the deadline for latecomers. Register to the Secretion Days in Marseille !

Julien GIRAUD@juliengiraud.bsky.social · 2mo ago

👉Reminder : FIVE DAYS LEFT👈 📅 Secretion Days 2026 will take place on October 8-9 in Marseille 🌊 🎤Invited speaker : Wilbert Bitter; @wilbertbitter.bsky.social 🆓 Free, spot are limited ! 📥 Registration is open until June 15 via the following link: docs.google.com/forms/d/e/1F...

Happy to share this one as a post-doc fellow, attempting to describe the T6SS biology in Stenotrophomonas and the role of its effectors. Work under the supervision of the great Alain Sarniguet at @emersys-irhs.bsky.social @irhs-angers.bsky.social

👉Reminder : FIVE DAYS LEFT👈 📅 Secretion Days 2026 will take place on October 8-9 in Marseille 🌊 🎤Invited speaker : Wilbert Bitter; @wilbertbitter.bsky.social 🆓 Free, spot are limited ! 📥 Registration is open until June 15 via the following link: docs.google.com/forms/d/e/1F...

Journées Sécrétion 2026

Contact: secretion@imm.cnrs.fr

docs.google.com

Happy to share the last publication of @bobytaillefer.bsky.social, showing that #T6SS heterogeneity is an attenuation strategy to optimizes the trade-off between competitive killing and survival.

PLOS Biology@plosbiology.org · 2mo ago

The T6SS is a widespread nanoweapon deployed by #bacteria, but why is it deployed heterogeneously? @cascaleslab.bsky.social &co show that #Ecoli adopt distinct #T6SS attacker "ON" & defender "OFF" roles to optimize survival, a key strategy in microbial warfare @plosbiology.org 🧪 plos.io/3S5dL45

Happy to share the last work of Jonas Desjardins, identifying and characterizing a novel Rhs NAD(P) glycohydrolase delivered by the #T6SS of the major cosmetic contaminant, Pluralibacter gergoviae. www.jbc.org/article/S002...

The T6SS is a widespread nanoweapon deployed by #bacteria, but why is it deployed heterogeneously? @cascaleslab.bsky.social &co show that #Ecoli adopt distinct #T6SS attacker "ON" & defender "OFF" roles to optimize survival, a key strategy in microbial warfare @plosbiology.org 🧪 plos.io/3S5dL45

Very happy to see the second story from my PhD out in @currentbiology.bsky.social An exciting project where we explored the roles of secretion systems and gliding motility in predatory behavior in F. johnsoniae. www.cell.com/current-biol...

Type VI and type IX secretion systems and gliding motility contribute to facultative predation by Flavobacterium johnsoniae

Paillat et al. show that Flavobacterium johnsoniae combines type VI and type IX secretion systems with gliding motility to efficiently kill diverse bacterial competitors. They demonstrate that nutrien...

cell.com

The Journées Sécrétion are back! 8th and 9th October in Marseille Keynote lecture by: @wilbertbitter.bsky.social Registration is open until June 15: docs.google.com/forms/d/e/1F... Organized by Romé Voulhoux @cascaleslab.bsky.social, @thicoz.bsky.social, Julien Giraud, Yaelle Aouizerate

Highly recommended “Secretion Days”, to be held in Marseille, France, on October 8 and 9, 2026. This year's keynote speaker is Wilbert Bitter: orcid.org/0000-0001-83...

Happy to share the last work of @jmartinkus.bsky.social, led by @dukasju.bsky.social Immunity arrays associated with Rhs and CDI toxins and linked to a novel genetic element (XPC cassette) confer protection against competitors. @currentbiology.bsky.social Kudos !! www.cell.com/current-biol...

Poly-immunity arrays associated with Rhs toxins confer wide protection against competitors

Martinkus et al. show that Photorhabdus and Xenorhabdus species encode arrays of immunity genes whose protein products neutralize toxins secreted by competitors. These arrays, often linked to Xer pass...

cell.com

Fantastic work from the fantastic @maellepllt.bsky.social 😍

Cascales Lab@cascaleslab.bsky.social · 9mo ago

Happy to share the last paper form the lab: Specialized shuttle proteins recognize T9SS signals and target effectors to their final destinations. Great work by @maellepllt.bsky.social, led by @thicoz.bsky.social in collaboration with @audebertstephane.bsky.social www.nature.com/articles/s42...

What if even the core of bacterial nanomachines wasn’t static? We found that the T3SS core protein SctD in Yersinia dynamically exchanges subunits — and this flexibility is essential for proper assembly & function. 🔗 www.nature.com/articles/s41... @kit.edu @t3sss.bsky.social

Thinking only of Rosalind Franklin today, and what was stolen from her (and so many other female scientists alongside her).

Rosalind Franklin and the damage of gender harassment

Spurred by a recent report on sexual harassment in academia, our columnist revisits a historical case and reflects on what has changed—and what hasn’t

science.org

Open position to work on Type IX secretion (#T9SS) in our lab, in collaboration withe the group of Eric Reynolds at the Dental School of the University of Melbourne. Please spread the word, and forward to anyone potentially interested ! Apply here: emploi.cnrs.fr/Offres/Docto...

Amazing science at the 2nd edition of the Secretion Days in Marseille 🌞 ! Huge thanks to all participants and to @archaellum.bsky.social for an outstanding opening talk. Looking forward to the next edition!

Extremely happy to share the fruit of a beautiful collaborative research study. France 🇫🇷, Russia 🇷🇺 and USA 🇺🇸 teaming up to tackle a long-standing question in the TB field! 🧫🦠💊🥼🩺 Our latest Preprint on Pyrazinamide Mode of Action against M.tuberculosis is online! 👇👇👇 doi.org/10.1101/2025...

Pyrazinamide kills Mycobacterium tuberculosis via pH-driven weak-acid permeation and cytosolic acidification

Pyrazinamide (PZA) is a cornerstone drug in tuberculosis (TB) treatment with a strong bactericidal activity in vivo on both actively and non-replicating bacterial subpopulations. Yet the precise mode ...

doi.org

Happy to share our work on a T6SS effector with ADP ribose cyclase activity, published in JBC @asbmbjournals.bsky.social Great work of Julius Martinkus @jmartinkus.bsky.social and (always) great collaboration with @dukasju.bsky.social and @laurentterradot.bsky.social www.jbc.org/article/S002...

Widespread deployment of the human CD38 ADP-ribosyl cyclase fold in antibacterial and anti-eukaryotic polymorphic toxins

Bacterial polymorphic toxins are modular weapons that mediate inter-microbial competition and host interactions by delivering diverse cytotoxic domains through specialized secretion systems. Here, we ...

jbc.org

Grateful to my PIs, team, collaborators, and colleagues for their support. Excited to share our paper from my PhD journey!

Cascales Lab@cascaleslab.bsky.social · 10mo ago

Happy to share our work on a T6SS effector with ADP ribose cyclase activity, published in JBC @asbmbjournals.bsky.social Great work of Julius Martinkus @jmartinkus.bsky.social and (always) great collaboration with @dukasju.bsky.social and @laurentterradot.bsky.social www.jbc.org/article/S002...

Open position !! Either at the Engineer or post-doctoral level, to work on filamentous phages. Collaboration between Laetitia Houot's group and Thierry Doan @thicoz.bsky.social. To apply at the E level: emploi.cnrs.fr/Offres/CDD/U... To apply at the post-doc level: emploi.cnrs.fr/Offres/CDD/U...

We recently described how T3SS effectors reach the injectisome with a shuttle system. But what about their chaperones? With live microscopy, proximity labeling and functional assays, @keithpint.bsky.social showed the Yersinia chaperone SycH already hands over its cargo in the cytosol. bit.ly/47hq6rM

🚨🔥 Happy to share our latest Preprint! 🔥🚨 We describe some very simple experimental approaches employed in our group to assess CRISPRi effectiveness in Mycobacteria 🧬 🦠 🧫 Project co-led by Vanessa, Wafaa, Janïs & Eliana - Our Fantastic 4 Female Scientists💫🙌🧨 www.biorxiv.org/cgi/content/...

Mycobacterial cell division arrest and smooth-to-rough envelope transition using CRISPRi-mediated genetic repression systems

The genetic basis underlying non-tuberculous mycobacteria (NTM) pathogenesis remains poorly understood. This gap in knowledge has been partially filled over the years through the generation of novel a...

biorxiv.org

bioRxiv Microbiology@biorxiv-microbiol.bsky.social · last yr.

Mycobacterial cell division arrest and smooth-to-rough envelope transition using CRISPRi-mediated genetic repression systems https://www.biorxiv.org/content/10.1101/2025.07.12.664508v1

We have an open engineer position to work on type IX secretion (T9SS), under the supervision of @doan_thierry (collab with HP Fierobe & A. Tolonen). 1-year contract, renewable up to 3.5 years. Please apply here or forward to anyone potentially interested: emploi.cnrs.fr/Offres/CDD/U...

Kicking off the week with exciting news: 🧐 There is still time to register and submit your abstract until 30th May for the 2nd edition of "Secretion Days" (October 2-3, Marseille). 💻Registration: docs.google.com/forms/d/e/1FAI… 📩 More info: secretion@imm.cnrs.fr

👉Reminder : ONE WEEK LEFT👈 📅 Secretion Days 2025 will take place on October 2–3 in Marseille 🌊 🎤Invited speaker : Sonja-Verena Albers; @archaellum.bsky.social 🆓 Free, spot are limited ! 📥 Registration is open until May 20 via the following link: docs.google.com/forms/d/e/1F...

Journées Sécrétion 2025

Contact: secretion@imm.cnrs.fr

docs.google.com

👉Don’t forget👈 📅 Secretion Days 2025 will take place on October 2–3 in Marseille 🌊 🎤Invited speaker : Sonja-Verena Albers; @archaellum.bsky.social 🆓 Free, spot are limited ! 📥 Registration is open until May 15 via the following link: 🔗 docs.google.com/forms/d/e/1F...

Journées Sécrétion 2025

Contact: secretion@imm.cnrs.fr

docs.google.com

You are a young researcher working on the bacterial cell envelope ? Don't miss this opportunity !!

Maelle Paillat@maellepllt.bsky.social · last yr.

The Journées Sécrétion are back! 2nd and 3rd October in Marseille Keynote lecture by: @archaellum.bsky.social Registration is open until May 15: forms.gle/2qxHntTktoxw... Organized by Romé Voulhoux @lcbofficiel.bsky.social, @cascaleslab.bsky.social, Thierry Doan, @juliengiraud.bsky.social

Thrilled and honored to join the organizing committee of the 2nd edition of the Journées Sécrétion! We look forward to seeing you there, in Marseille🌞, reconnecting, and discovering exciting new research. See you soon!

Maelle Paillat@maellepllt.bsky.social · last yr.

The Journées Sécrétion are back! 2nd and 3rd October in Marseille Keynote lecture by: @archaellum.bsky.social Registration is open until May 15: forms.gle/2qxHntTktoxw... Organized by Romé Voulhoux @lcbofficiel.bsky.social, @cascaleslab.bsky.social, Thierry Doan, @juliengiraud.bsky.social

The Journées Sécrétion are back! 2nd and 3rd October in Marseille Keynote lecture by: @archaellum.bsky.social Registration is open until May 15: forms.gle/2qxHntTktoxw... Organized by Romé Voulhoux @lcbofficiel.bsky.social, @cascaleslab.bsky.social, Thierry Doan, @juliengiraud.bsky.social

Happy to see our work on Mycobacterial CRISPRI featured on the Cover of FEBS Letters 🍾🥳👌 @febspress.bsky.social @univ-amu.fr @cnrsbiologie.bsky.social @anrs-mie.bsky.social

We have an open PhD position to work on bacterial secretion systems. Please RT, write us or apply through the CNRS job portal: t.co/HxX23Od1oa